Spontaneous mutagenesis is enhanced in Apex heterozygous mice

scientific article published on September 2004

Spontaneous mutagenesis is enhanced in Apex heterozygous mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.24.18.8145-8153.2004
P932PMC publication ID515041
P698PubMed publication ID15340075
P5875ResearchGate publication ID8372640

P2093author name stringDavid J Chen
John R McCarrey
C Alex McMahan
Christi A Walter
Damon C Herbert
Robert Reddick
Jessica Huamani
Mark I MacInnes
P2860cites workMammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombinationQ24311337
Identification of redox/repair protein Ref-1 as a potent activator of p53Q24316161
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzymeQ24555669
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombinationQ24647280
Parent-of-origin effects in multiple endocrine neoplasia type 2BQ24672503
Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a CalcitonineQ24680144
Suppression of spontaneous mutagenesis in human cells by DNA base excision-repairQ28142064
The origins, patterns and implications of human spontaneous mutationQ28206110
Rate of depurination of native deoxyribonucleic acidQ28243811
Mutagenesis by apurinic/apyrimidinic sitesQ28300337
A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.Q52182528
Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp 70-2 knockout mice.Q52197889
Difference in the expression level of DNA polymerase beta among mouse tissues: high expression in the pachytene spermatocyte.Q52247063
Spontaneous mutation in manQ67508556
Migration of gonocytes into the mammalian gonad and their differentiationQ68757969
Kinetics of gametogenesis. I. Comparative histological and autoradiographic studies of oocytes and transitional prospermatogonia during oogenesis and prespermatogenesisQ68857006
Identification of transgenic mice carrying the CAT gene with PCR amplificationQ69455485
Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytesQ70738624
Expression of the DNA repair gene XRCC1 in baboon tissuesQ70793932
Xrcc-1 expression during male meiosis in the mouseQ71666068
Purification, culture, and fractionation of spermatogenic cellsQ72583949
Effect of aging on spontaneous and induced mouse testicular germ cell apoptosisQ74607364
The mutation rate of the gene for haemophilia, and its segregation ratios in males and femalesQ83229412
Testicular germ cell apoptosis in Bcl6-deficient miceQ28509583
Highly efficient base excision repair (BER) in human and rat male germ cellsQ28580367
Repair of oxidative damage to DNA: enzymology and biologyQ29618065
Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterizationQ29619534
Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.Q33182233
Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissuesQ33864452
An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesisQ33886497
Germ cell suicide: new insights into apoptosis during spermatogenesisQ33910562
Base excision repair in yeast and mammalsQ33984258
Going APE over ref-1.Q34053099
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesisQ34132208
Cellular responses to DNA damageQ34192725
Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old miceQ34276065
Base excision repair in a network of defence and toleranceQ34283911
Exclusive paternal origin of new mutations in Apert syndromeQ34385938
The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA.Q34390593
The occurrence of new mutants in the X-linked recessive Lesch-Nyhan diseaseQ34532438
The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domainsQ34878594
Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 miceQ35582963
Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged miceQ35919383
Mutation frequency declines during spermatogenesis in young mice but increases in old miceQ36283159
Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic miceQ37592150
Infidelity of DNA synthesis associated with bypass of apurinic sitesQ37601868
Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA bindingQ38316481
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.Q38319417
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activityQ38330722
Study design and sample sizes for a lacI transgenic mouse mutation assayQ38464863
Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activityQ38660638
Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutationQ40640344
Testis and somatic Xrcc-1 DNA repair gene expressionQ41013512
DNA polymerase-beta and poly(ADP)ribose polymerase mRNAs are differentially expressed during the development of male germinal cellsQ44834025
Evidence that the mechanism of prenatal germ cell death in the mouse is apoptosisQ46425526
Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.Q47197545
The Big Blue(R) transgenic mouse mutation detection assay: the mutation pattern of sectored mutant plaquesQ47605363
Spontaneous mutations in the Big Blue transgenic system are primarily mouse derivedQ47607298
The rate of spontaneous mutation of a human gene. 1935.Q48636282
On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice.Q50530799
Towards validation of the Big Blue transgenic mouse mutagenesis assay: the mutational spectrum of ex vivo pinpoint mutant plaques.Q50534022
The genetic analysis of lacI mutations in sectored plaques from Big Blue transgenic mice.Q50753668
p53-mediated germ cell quality control in spermatogenesis.Q52181513
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectheterozygosityQ124059385
P304page(s)8145-8153
P577publication date2004-09-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleSpontaneous mutagenesis is enhanced in Apex heterozygous mice
P478volume24

Reverse relations

cites work (P2860)
Q54586051A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Q36081999Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice
Q34364004BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice
Q27025537Base excision repair and cancer
Q34586254Base excision repair capacity in informing healthspan
Q36853499Base excision repair, aging and health span.
Q36241549DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents
Q39211298Decrease in abundance of apurinic/apyrimidinic endonuclease causes failure of base excision repair in culture-adapted human embryonic stem cells.
Q36828516Differential expression of hepatic apurinic/apyrimidinic endonuclease 1, a DNA repair enzyme, in chronic hepatitis
Q52975832Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate.
Q37455875Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.
Q34311964Enhanced genetic integrity in mouse germ cells
Q33258826Evidence for diversity in transcriptional profiles of single hematopoietic stem cells
Q36326761Folate and colorectal cancer in rodents: a model of DNA repair deficiency
Q37939634Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance
Q34517201Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway
Q37512952Human apurinic/apyrimidinic endonuclease 1.
Q34904605Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry
Q36011837Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice
Q42557573Ionizing radiation-induced mutant frequencies increase transiently in male germ cells of older mice
Q55664832Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer.
Q37185383Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice
Q37179525Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.
Q26992194Pathways for repairing and tolerating the spectrum of oxidative DNA lesions
Q36955832Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.
Q36891621Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis
Q28386202Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis
Q36694479S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis
Q38925522The prion protein is critical for DNA repair and cell survival after genotoxic stress
Q38717164Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes
Q35672223Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability
Q34983433Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells

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