Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.

scientific article published on 18 February 2004

Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M313983200
P698PubMed publication ID14973123

P50authorLisiane B MeiraQ56432067
P2093author name stringJun Nakamura
Errol C Friedberg
Ahmad R Heydari
Diane C Cabelof
Julian J Raffoul
P2860cites workInteraction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathwayQ24313920
Identification of redox/repair protein Ref-1 as a potent activator of p53Q24316161
XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactionsQ24535921
A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stressQ40231225
Quantification of 3'OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assayQ41223814
Oxidative stress associated DNA damage in testis of mice: induction of abnormal sperms and effects on fertilityQ43806323
Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivoQ44110036
Drosophila S3 ribosomal protein accelerates repair of 8-oxoguanine performed by human and mouse cell extractsQ44521596
Comparative analysis of the ability of precursor germ cells and epididymal spermatozoa to generate reactive oxygen metabolites.Q46593635
Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining stepsQ47724136
A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.Q52182528
Reduction of oxidation during the preparation of DNA and analysis of 8-hydroxy-2'-deoxyguanosine.Q52237775
Quantitative analysis of gene-specific DNA damage in human spermatozoa.Q53919370
A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterizationQ54693226
Lipid Peroxidation and the Reactions of Superoxide and Hydrogen Peroxide in Mouse SpermatozoaQ70217313
Carboplatin treatment induces dose-dependent increases in the frequency of micronuclei in Ehrlich ascites tumor cellsQ71631641
Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage. Version 5Q73314976
Passing the baton in base excision repairQ73505096
Genetic interaction between HAP1/REF-1 and p53Q73777265
AP endonuclease 1 has no biologically significant 3(')-->5(')-exonuclease activityQ78654167
Isolation of cDNA clones encoding a human apurini/apyrimidinic endonuclease that corects DNA repair and mutagenisis defects inE.coli xth(exonuclease III) mutantsQ24629413
p53, the cellular gatekeeper for growth and divisionQ27860990
Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IVQ27930192
Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activityQ28202324
Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1Q28203088
DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extractsQ28365541
Highly efficient base excision repair (BER) in human and rat male germ cellsQ28580367
Mechanisms of human DNA repair: an updateQ28608973
Incision Activity of Human Apurinic Endonuclease (Ape) at Abasic Site Analogs in DNAQ28609201
Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repairQ28645611
Completion of base excision repair by mammalian DNA ligasesQ28645625
A quantitative model of human DNA base excision repair. I. Mechanistic insightsQ28646701
Functional characterization of Ape1 variants identified in the human populationQ33786876
Going APE over ref-1.Q34053099
Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related declineQ34172771
Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity stepQ34286685
The stalling of transcription at abasic sites is highly mutagenicQ34463060
p53 regulation of DNA excision repair pathwaysQ34552957
A role for p53 in base excision repair.Q34582602
Polymorphisms in DNA repair and environmental interactionsQ34994597
Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA bindingQ35019872
Dynamics and diversions in base excision DNA repair of oxidized abasic lesionsQ35026374
DNA damage and repairQ35050625
Repair mechanisms for oxidative DNA damageQ35109446
Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genesQ35114513
Biochemical entities involved in reactive oxygen species generation by human spermatozoa.Q35136630
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damageQ35576447
Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged miceQ35919383
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.Q37377727
Infidelity of DNA synthesis associated with bypass of apurinic sitesQ37601868
Base excision repair intermediates as topoisomerase II poisonsQ38295973
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.Q38319417
Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activityQ38660638
P433issue18
P407language of work or nameEnglishQ1860
P921main subjecthaploinsufficiencyQ852654
P304page(s)18425-18433
P577publication date2004-02-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleApurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair
P478volume279

Reverse relations

cites work (P2860)
Q54586051A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Q34864938A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta
Q55402216APE1 deficiency promotes cellular senescence and premature aging features.
Q36229211APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
Q27025537Base excision repair and cancer
Q37325427Base excision repair in the mammalian brain: implication for age related neurodegeneration
Q40177980Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex
Q40300992Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity
Q36241549DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents
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Q28822387Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver
Q37455875Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.
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Q37185383Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice
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Q37179525Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.
Q28256164Sequence-specific cleavage of dsRNA by Mini-III RNase
Q37493345Spontaneous mutagenesis is enhanced in Apex heterozygous mice
Q46497055The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry

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