Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease

scientific article published on 21 January 2014

Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...985613E
P356DOI10.1371/JOURNAL.PONE.0085613
P932PMC publication ID3897457
P698PubMed publication ID24465619
P5875ResearchGate publication ID259919841

P50authorDouglas F. NixonQ44059330
Steven G DeeksQ57425986
P2093author name stringJoseph M McCune
Jeffrey N Martin
Brinda Emu
Rebecca Hoh
Walter J Moretto
Melissa Krone
P2860cites workMicrobial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosisQ24672191
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Use of a photolabeling technique to identify nonviable cells in fixed homologous or heterologous cell populationsQ30983449
Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV diseaseQ33528999
AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort StudyQ33884269
Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studiesQ34139859
Altered representation of naive and memory CD8 T cell subsets in HIV-infected childrenQ34215632
CD8 naive T cell counts decrease progressively in HIV-infected adultsQ34215781
Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapyQ34384134
Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapyQ34384143
CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHEREQ35842386
HIV-1 replication activates CD4+ T cells with specificities for persistent herpes virusesQ36039280
Accelerated immune senescence and HIV-1 infectionQ36738887
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapyQ36974912
HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cellsQ37000907
Phenotype and function of human T lymphocyte subsets: consensus and issuesQ37266382
Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infectionQ37309633
Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study.Q38476717
HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesisQ41952863
Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians.Q42608072
HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.Q43130032
Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen loadQ43779427
Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlationsQ44096645
Skewed maturation of memory HIV-specific CD8 T lymphocytesQ45284555
Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapyQ45353124
Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumesQ45723070
Different rates of CD4+ and CD8+ T-cell proliferation in interleukin-2-treated human immunodeficiency virus-positive subjects.Q45735994
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).Q45745522
CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use.Q46405812
Reference intervals of CD3, CD4, CD8, CD4/CD8, and absolute CD4 values in Asian and Non-Asian populationsQ46768556
Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients.Q51016644
Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry.Q51186094
T-cell dynamics after high-dose chemotherapy in adults: elucidation of the elusive CD8+ subset reveals multiple homeostatic T-cell compartments with distinct implications for immune competence.Q52013209
Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians.Q52046882
CD4+ T cell count recovery in HIV type 1-infected patients is independent of class of antiretroviral therapy.Q53455078
Immunological abnormalities in asymptomatic homosexual men: correlation with antibody to HTLV-III and sequential changes over two years.Q55243643
Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort studyQ56539634
An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian HumansQ56986846
Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in agingQ57010350
HIV Persistence in the Gut Mucosa of HIV-Infected Subjects Undergoing Antiretroviral Therapy Correlates with Immune Activation and Increased Levels of LPSQ57573965
Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infectionQ72668437
Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune studyQ77162659
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
anti-retroviral agentQ50430310
P304page(s)e85613
P577publication date2014-01-21
P1433published inPLOS OneQ564954
P1476titleComposition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease
P478volume9

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cites work (P2860)
Q35801549CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients
Q41609336Course and Clinical Significance of CD8+ T-Cell Counts in a Large Cohort of HIV-Infected Individuals
Q37620588Diminished CD103 (αEβ7) Expression on Resident T Cells from the Female Genital Tract of HIV-Positive Women
Q36402470Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts
Q34004816Early skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progression
Q98231944Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study
Q26768147Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era
Q46042029HIV and Age Do Not Synergistically Affect Age-Related T cell Markers
Q38947827HIV-related pneumococcal disease prevention in adults.
Q38981750Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana
Q94539336IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection
Q35854044Immunosenescence of the CD8(+) T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls
Q33637866Impact of illicit opioid use on T cell subsets among HIV-infected adults
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Q36072424Neurocognitive decline in HIV patients is associated with ongoing T-cell activation in the cerebrospinal fluid.
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Q61797436Suboptimal Immune Reconstitution among HIV-Infected Saudi Patients following Successful Antiretroviral Treatment
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Q56912967The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis
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