Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation

scientific article published on 02 January 2014

Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DEVCEL.2013.12.001
P932PMC publication ID3898610
P698PubMed publication ID24389063
P5875ResearchGate publication ID259586953

P50authorJeremy MetzQ42323561
Daniel HaywardQ85593387
P2093author name stringClaudia Pellacani
James G Wakefield
P2860cites workIdentification of a TPX2-like microtubule-associated protein in DrosophilaQ21090968
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cellsQ24316058
Genes required for mitotic spindle assembly in Drosophila S2 cellsQ24629513
Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosisQ24676290
Meiosis-specific stable binding of augmin to acentrosomal spindle poles promotes biased microtubule assembly in oocytesQ27322039
Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytesQ27339353
HURP is part of a Ran-dependent complex involved in spindle formationQ28235925
Reconstitution of a microtubule plus-end tracking system in vitroQ28259992
Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extractsQ29616137
Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cellsQ30441480
Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosominQ30480537
Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindleQ30483296
Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosisQ30486464
Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cellsQ30487858
Model for anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongationQ30835545
Centrosome-independent mitotic spindle formation in vertebratesQ31494302
Making microtubules and mitotic spindles in cells without functional centrosomesQ33236955
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2.Q34328106
Insights into the micromechanical properties of the metaphase spindleQ34630610
RanGTP is required for meiotic spindle organization and the initiation of embryonic development in DrosophilaQ35576452
Misregulation of the kinesin-like protein Subito induces meiotic spindle formation in the absence of chromosomes and centrosomesQ36052270
Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequenciesQ36219356
The chromosomal passenger complex is required for meiotic acentrosomal spindle assembly and chromosome biorientationQ36268085
Spindle assembly in Xenopus egg extracts: respective roles of centrosomes and microtubule self-organizationQ36276356
Augmin: a protein complex required for centrosome-independent microtubule generation within the spindleQ36625777
Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stabilityQ36749661
mei-38 is required for chromosome segregation during meiosis in Drosophila femalesQ36873799
Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity.Q37239312
A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes.Q37302882
Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions.Q38474293
In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis.Q44718896
Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM.Q47070388
Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytesQ48785884
Bipolar meiotic spindle formation without chromatin.Q50742045
Zygotic development without functional mitotic centrosomes.Q52138911
Drosophila Dgt6 interacts with Ndc80, Msps/XMAP215, and gamma-tubulin to promote kinetochore-driven MT formation.Q52699511
HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of ChromosomesQ57985121
On the physical properties of the mitotic spindleQ78896783
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages13
P304page(s)81-93
P577publication date2014-01-02
P1433published inDevelopmental CellQ1524277
P1476titleSynergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation
P478volume28

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cites work (P2860)
Q42224045A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly.
Q42924741Acentrosomal Drosophila epithelial cells exhibit abnormal cell division, leading to cell death and compensatory proliferation
Q28078705Anaphase B
Q92197843Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth
Q83224534Biochemical reconstitution of branching microtubule nucleation
Q58697392Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in
Q92339367Centrosome Loss Triggers a Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress
Q38587415Centrosome function and assembly in animal cells.
Q36501313Centrosomes are multifunctional regulators of genome stability
Q38661407Centrosomes in spindle organization and chromosome segregation: a mechanistic view
Q48139993Centrosomin represses dendrite branching by orienting microtubule nucleation
Q42729204Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos.
Q33743385Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle
Q92152613Direct observation of branching MT nucleation in living animal cells
Q27311109Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivo
Q64111237Drawing and the dynamic nature of living systems
Q92452377Drosophila Morgana is an Hsp90-interacting protein with a direct role in microtubule polymerisation
Q50099523Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation
Q27302069Human Nek7-interactor RGS2 is required for mitotic spindle organization
Q83224512In vitro reconstitution of branching microtubule nucleation
Q92763208MTOC Organization and Competition During Neuron Differentiation
Q35529934Mechanism for Anaphase B: Evaluation of "Slide-and-Cluster" versus "Slide-and-Flux-or-Elongate" Models
Q37242379Mechanisms of Mitotic Spindle Assembly
Q37118724Microtubule nucleation and organization in dendrites
Q35876401Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected].
Q37728172Mitotic Spindle Assembly in Land Plants: Molecules and Mechanisms
Q38973298Mitotic spindle assembly in animal cells: a fine balancing act.
Q34575205Reconstitution of the augmin complex provides insights into its architecture and function.
Q44483999Sliding filaments and mitotic spindle organization
Q64062095Spatiotemporal organization of branched microtubule networks
Q59808620Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation
Q43200940Structural insight into TPX2-stimulated microtubule assembly.
Q38661406The Janus soul of centrosomes: a paradoxical role in disease?
Q90663362The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway
Q26774420The Ran Pathway in Drosophila melanogaster Mitosis
Q88178344The dynamics of microtubule minus ends in the human mitotic spindle
Q30638664The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos
Q37297112The sequential activation of the mitotic microtubule assembly pathways favors bipolar spindle formation

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