Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.

scientific article published on May 1991

Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1991PNAS...88.4186B
P356DOI10.1073/PNAS.88.10.4186
P932PMC publication ID51623
P698PubMed publication ID2034663
P5875ResearchGate publication ID21120674

P50authorMaurizia R BrunettoQ56940371
F OliveriQ68247622
P2093author name stringH Will
M Baldi
A Serra
G Verme
E Chiaberge
A Alfarano
G Saracco
M M Giarin
P2860cites workA signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytesQ33669396
Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?Q33762446
Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coliQ34051296
Immunoelectron microscopic observation of intrahepatic HBeAg in patients with chronic hepatitis B.Q34756315
Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigenQ35594167
Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigenQ36802480
Chronic type B hepatitis and the "healthy" HBsAg carrier stateQ39662797
Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection.Q41277179
Precore sequence of hepatitis B virus inducing e antigen and membrane association of the viral core proteinQ41451798
Contribution of low level HBV replication to continuing inflammatory activity in patients with anti-HBe positive chronic hepatitis B virus infectionQ43216710
Detection and characterization of hepatitis B virus DNA in serum of HBe antigen-negative HBsAg carriersQ43564515
Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patientQ43798496
Hepatitis B virus DNA in the sera of HBsAg carriers: a marker of active hepatitis B virus replication in the liver.Q44252034
Perinatal transmission of the hepatitis B virus and of the HBV-associated delta agent from mothers to offspring in northern ItalyQ45792950
Analysis of liver disease, nuclear HBcAg, viral replication, and hepatitis B virus DNA in liver and serum of HBeAg Vs. anti-HBe positive carriers of hepatitis B virusQ45795119
Natural history of chronic hepatitis B virus-related liver disease and its relationship to serum markers of viral replicationQ45830504
Chronic persistent hepatitis type B can be a progressive disease when associated with sustained virus replicationQ45848808
Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C regionQ45849206
A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B.Q45849284
A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitisQ45850121
Rapid detection and further characterization of infection with hepatitis B virus variants containing a stop codon in the distal pre-C regionQ45850180
Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigenQ61054126
Chronic hepatitis in HBsAg carriers with serum HBV-DNA and anti-HBeQ70029659
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecthepatitis BQ6853
P304page(s)4186-4190
P577publication date1991-05-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleWild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis
P478volume88

Reverse relations

cites work (P2860)
Q45397200A complete genomic analysis of hepatitis B virus genotypes and mutations in HBeAg-negative chronic hepatitis B in China
Q37571503A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen
Q38526946A novel primer-extension assay for the detection of a G to A mutation in the distal precore region of hepatitis B virus DNA.
Q56979536A novel stop codon mutation within the hepatitis B surface gene is detected in the liver but not in the peripheral blood mononuclear cells of HIV-infected individuals with occult HBV infection
Q41331972A practical guide to the use of interferons in the management of hepatitis virus infections
Q71622433A randomized, double-blind, controlled trial of natural interferon-beta therapy for e-antigen-negative chronic hepatitis B patients with abnormal transaminase levels
Q41843085A survey of liver pathology in needle biopsies from HBsAg and anti-HBe positive individuals
Q35689607A treatment algorithm for the management of chronic hepatitis B virus infection in the United States
Q35053121A336C/A336T/T337C variations in HBV core gene and spontaneous hepatitis B e antigen loss in chronic hepatitis B patients
Q36309215Abnormal immunity and gene mutation in patients with severe hepatitis-B
Q30391932Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
Q33841903Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients.
Q36841560Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
Q45224986Characteristics of adefovir resistance in patients with or without lamivudine-resistant hepatitis B virus treated with adefovir: a 4-year experience
Q45368640Characterization of the basal core promoter and precore regions in anti-HBe-positive inactive carriers of hepatitis B virus
Q35621709Chronic hepatitis B e antigen (HBeAg) negative, anti-HBe positive hepatitis B: an overview
Q34002160Chronic hepatitis B.
Q45756207Clinical and molecular virological differences between fulminant hepatic failures following acute and chronic infection with hepatitis B virus
Q33879651Clinical efficacy of a 24-months course of lamivudine therapy in patients with HBeAg negative chronic hepatitis B: a long-term prospective study
Q35668730Clinical relevance of hepatitis B virus variants
Q34231638Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan
Q41474751Clinical, epidemiological and virological features of acute hepatitis B in Italy.
Q33651263Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination
Q45779448Coinfection study of precore mutant and wild-type hepatitis B-like virus in ducklings
Q44116425Colourimetric point mutation assay: for detection of precore mutants of hepatitis B
Q40707293Combination and evolution of HBV mutant strains in the HBeAg-positive status predict clinical outcomes after HBeAg seroconversion
Q40707285Combining the HBsAg decline and HBV DNA levels predicts clinical outcomes in patients with spontaneous HBeAg seroconversion
Q37365416Cytotoxic T cells and viral hepatitis
Q45742069Decrease of wild-type and precore mutant duck hepatitis B virus replication during lamivudine treatment in white Pekin ducks infected with the viruses
Q39401804Detection of hepatitis B pre-core mutant by allele specific polymerase chain reaction
Q45778427Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members
Q33592384Development of a molecular-beacon assay to detect the G1896A precore mutation in hepatitis B virus-infected individuals
Q40817612Diagnostic markers of viral hepatitis B and C.
Q45750996Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion
Q27022216Direct acting antivirals for the treatment of chronic viral hepatitis
Q45769436Distribution of the predominant hepatitis B virus precore variants in hepatitis B e antigen-positive children and their effect on treatment response
Q36832325Drug resistance in antiviral treatment for infections with hepatitis B and C viruses
Q36201563Drugs in development for hepatitis B.
Q34179245Early termination of immune tolerance state of hepatitis B virus infection explains liver damage
Q39474534Effects of hepatitis B virus precore and basal core promoter mutations on the expression of viral antigens: genotype B vs C
Q35967369Emerging treatments in chronic hepatitis B.
Q64267288Epidemiology, Clinical Characteristics, and Management Status of Hepatitis B: A Cross-sectional Study in a Tertiary Care Hospital at Karachi, Pakistan
Q35073136European multicenter evaluation of high-density DNA probe arrays for detection of hepatitis B virus resistance mutations and identification of genotypes
Q73130886Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection
Q35073559Expertise of laboratories in viral load quantification, genotyping, and precore mutant determination for hepatitis B virus in a multicenter study
Q35568019Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection
Q50585410Extended follow-up of anti-HBe-positive patients with chronic hepatitis B retreated with ribavirin and interferon-α
Q40466510Fibrosing cholestatic hepatitis and HBV after bone marrow transplantation
Q33297950Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics
Q42251194Full genome ultra-deep pyrosequencing associates G-to-A hypermutation of the hepatitis B virus genome with the natural progression of hepatitis B.
Q28298591Genetic Variations of the Hepatitis B Virus and Their Clinical Relevance
Q73343737HBV DNA levels and transmission of hepatitis B by health care workers
Q33801305HBeAg negative variants and their role in the natural history of chronic hepatitis B virus infection
Q37254285HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations
Q38859190Hepatitis B "e" antigen-mediated inhibition of HBV replication fitness and transcription efficiency in vitro
Q37571886Hepatitis B Virus e Antigen Regulates Monocyte Function and Promotes B Lymphocyte Activation
Q38776158Hepatitis B e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 activity.
Q58598672Hepatitis B e antigen inhibits NF-κB activity by interrupting K63-linked ubiquitination of NEMO
Q36651995Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region.
Q45368933Hepatitis B virus genotype B results in better immediate, late and sustained responses to peginterferon‐alfa in hepatitis‐B‐e‐antigen‐positive patients
Q43510252Hepatitis B virus genotypes in the United States: results of a nationwide study
Q45870499Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity
Q45769136Hepatitis B virus precore mutants in HBeAg carriers with chronic hepatitis treated with interferon
Q34124642Hepatitis B virus precore mutation and fulminant hepatitis in the United States. A polymerase chain reaction-based assay for the detection of specific mutation
Q35232789Hepatitis B viruses and hepatocellular carcinoma
Q37729188Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg+/HBeAg- mothers
Q33204408High frequency of the 1896 precore mutation in patients and blood donors with hepatitis B virus infection from the Indian subcontinent
Q45751000High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers.
Q42217489High risk of hepatitis B virus reactivation in nucleos(t)ide analogue-induced hepatitis B e antigen seroconverters older than 40 years
Q40633175Host immune response and variations in the virus genome: pathogenesis of liver damage caused by hepatitis B virus
Q59357583Identification of novel susceptibility loci associated with hepatitis B surface antigen seroclearance in chronic hepatitis B
Q34700332Immune response and tolerance during chronic hepatitis B virus infection
Q33835018Immune tolerance split between hepatitis B virus precore and core proteins
Q34416274Immunopathogenesis of hepatitis B e antigen negative chronic hepatitis B infection
Q37344233Immunopathology of hepatitis B virus infection
Q37196478Impact of Nucleotide Mutations at the HNF3- and HNF4-Binding Sites in Enhancer 1 on Viral Replication in Patients with Chronic Hepatitis B Virus Infection
Q35785174In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication
Q45753677Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen‐negative patients
Q45763604Increasing heterogeneity of the 'a' determinant of HBsAg found in the presumed late phase of chronic hepatitis B virus infection
Q45758549Influence of T‐helper cell subsets and crossregulation in hepatitis B virus infection
Q42244740JSH Guidelines for the Management of Hepatitis B Virus Infection
Q36153966KASL Clinical Practice Guidelines: Management of chronic hepatitis B
Q26752475KASL clinical practice guidelines: management of chronic hepatitis B
Q27468616Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in Patients
Q92035063Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients
Q45744780Latent hepatitis B virus infection in healthy individuals with antibodies to hepatitis B core antigen
Q28372760Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine
Q45397821Longitudinal changes in serum HBV DNA levels and predictors of progression during the natural course of HBeAg-negative chronic hepatitis B virus infection
Q24801344Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers
Q38071403Management of acute hepatitis B and reactivation of hepatitis B
Q34328969Mathematical Models of E-Antigen Mediated Immune Tolerance and Activation following Prenatal HBV Infection
Q41667248Molecular biology of hepatitis B virus e antigen
Q37250341Molecular characteristics and stages of chronic hepatitis B virus infection
Q41870815Molecular characterization of hepatitis B virus X gene in chronic hepatitis B patients
Q34293921Mutant hepatitis B viruses: a matter of academic interest only or a problem with far-reaching implications?
Q45750470Mutations in the basic core promotor and the precore region of hepatitis B virus and their selection in children with fulminant and chronic hepatitis B.
Q33671155Naturally occurring variants of hepatitis B virus
Q38215650New perspective on the natural course of chronic HBV infection
Q41251653Nonresponse to hepatitis B vaccines and the kinetics of anti-HBs production
Q72408116Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon
Q72179901Nucleotide sequence analysis of the precore region in patients with spontaneous reactivation of chronic hepatitis B
Q45742072Olone modulates the therapeutic effect of interferon to eliminate preferentially the hepatitis B virus precore stop mutant
Q34539997Outbreak of hepatitis B virus infections associated with assisted monitoring of blood glucose in an assisted living facility-Virginia, 2010.
Q61054098Outcome of anti-HBe positive chronic hepatitis B in alpha-interferon treated and untreated patients: a long term cohort study
Q46552174Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine
Q45763494Outcome of liver disease and response to interferon treatment are not influenced by hepatitis B virus core gene variability in children with chronic type B hepatitis
Q45765040Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg
Q33925491Pathogenesis of hepatitis B virus infection
Q41556990Patients with interferon-induced HBeAg seroconversion have a higher risk of HBV reactivation and HBeAg seroreversion
Q37267440Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load
Q73523464Persistence of viral replication after anti-HBe seroconversion during antiviral therapy for chronic hepatitis B
Q45416046Possible association of vigorous hepatitis B virus replication with the development of fulminant hepatitis
Q34552034Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation
Q73246101Pre-core mutant infections in the Canadian Inuit
Q45766435Pre-core mutants of hepatitis B virus in patients receiving immunosuppressive treatment after orthotopic liver transplantation
Q33945490Precore Stop Mutant in HBeAg-Positive Patients with Chronic Hepatitis B: Clinical Characteristics and Correlation with the Course of HBeAg-to-Anti-HBe Seroconversion
Q46219118Precore and basal core promoter mutations in Asian American patients with hepatitis B e antigen‐positive chronic hepatitis B
Q36535912Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic
Q45782497Precore region mutation in hepatitis B virus genome in early stage of infection: a study in hepatitis B e antigen-positive young carriers
Q74027206Precore wild-type DNA and immune complexes persist in chronic hepatitis B after seroconversion: No association between genome conversion and seroconversion
Q40045731Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.
Q45361924Precore/core promoter mutations and hepatitis B virus genotype in hepatitis B and C dually infected patients treated with interferon-based therapy
Q33764123Prevalence and Characteristics of Precore Mutation in Iran and Its Correlation with Genotypes of Hepatitis B.
Q45788252Prevalence of precore‐defective mutant of hepatitis B virus in HBV carriers
Q74497588Prevention of severe hepatic injury by interferon-α in chronic active hepatitis lacking HBeAg (mutant strain) in a patient with malignant lymphoma
Q45749810Progression of the proportion of hepatitis B virus precore stop mutant following acute superinfection of hepatitis C.
Q35840358Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion
Q39848558Rapid and sensitive assays for determination of hepatitis B virus (HBV) genotypes and detection of HBV precore and core promoter variants
Q45740320Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and disease severity
Q44902829Rare pre-core stop-codon mutant nt. 1897 predominates over wide-spread mutant nt. 1896 in an unusual course of chronic hepatitis B.
Q36150595Reactivation of hepatitis B virus with rituximab.
Q40484914Recent advances in the molecular biology of hepatitis B virus: mutant virus and the host response
Q43993353Relationship of clinical and virological factors with hepatitis activity in hepatitis B e antigen-negative chronic hepatitis B virus-infected patients
Q45765645Semiquantitative assessment of pre-core stop-codon mutant and wildtype hepatitis B virus during the course of chronic hepatitis B using a new PCR-based assay
Q43993339Sequential analysis of hepatitis B virus core promoter and precore regions in cancer survivor patients with chronic hepatitis B before, during and after interferon treatment
Q27470232Stealth and cunning: hepatitis B and hepatitis C viruses
Q34205905TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence
Q45256268The Hepatitis B Virus e Antigen Cannot Pass the Murine Placenta Efficiently and Does Not Induce CTL Immune Tolerance in H-2bMicein Utero
Q35664171The chimpanzee model for hepatitis B virus infection
Q39474523The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes
Q35879066The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype.
Q35784981The level of viral antigen presented by hepatocytes influences CD8 T-cell function.
Q64132783The natural history of chronic hepatitis B virus infection
Q33937762The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host
Q45757308The two different states of hepatitis B virus DNA in asymptomatic carriers: HBe-antigen-positive versus anti-HBe-positive asymptomatic carriers
Q37021822Therapeutic strategies in the management of patients with chronic hepatitis B virus infection.
Q43892791There were no differences in serum HBV DNA level between HBeAg-positive and HBeAg-negative chronic hepatitis B with same liver histological necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned by the same hepatic parenchyma
Q44248105Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS.
Q33753991Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy.
Q37195244Understanding the immunopathogenesis of chronic hepatitis B virus: an Asian prospective.
Q35938992Universal emergence of precore mutant hepatitis B virus along with seroconversion to anti-HBe irrespective of subsequent activity of chronic hepatitis B.
Q40966818Update on viral hepatitis in children
Q43030555Virological analysis, genotypes and mutational patterns of the HBV precore/core gene in HBV/HCV-related hepatocellular carcinoma.
Q34536159World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants

Search more.