IL-13 is a therapeutic target in radiation lung injury.

scientific article published on 22 December 2016

IL-13 is a therapeutic target in radiation lung injury. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP39714
P932PMC publication ID5177927
P698PubMed publication ID28004808

P50authorJoseph R ArronQ61147913
Bradley T ScrogginsQ114883608
P2093author name stringThomas A Wynn
Thirumalai R Ramalingam
Eun Joo Chung
Jason A Horton
Deborah E Citrin
Su I Chung
Kathryn E Hudak
Ayla O White
P2860cites workEffect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical TrialQ38396364
Effect of pentoxifylline on radiation response of non-small cell lung cancer: a phase III randomized multicenter trialQ38526067
Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthmaQ39792840
Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2.Q39994240
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trialQ40445632
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial.Q40672713
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin productionQ40849898
Requirement for IL-13 independently of IL-4 in experimental asthmaQ41881960
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).Q42101278
Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung.Q42464320
Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiationQ42489472
IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in miceQ43803704
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independentQ44007756
Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre studyQ44799322
Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agentQ44826352
Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.Q44937602
Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanismsQ45736589
Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthmaQ45802993
IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndromeQ46046480
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.Q46784009
Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammationQ46948858
Target cells in radiation pneumopathyQ47232808
Type 1/type 2 cytokine paradigm and the progression of pulmonary fibrosisQ49163938
Characterization of the interaction between interleukin-13 and interleukin-13 receptorsQ28248430
IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblastsQ28267624
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosisQ28285105
Interleukin-13: central mediator of allergic asthmaQ28291712
Macrophage activation and polarization: nomenclature and experimental guidelinesQ29620642
Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studiesQ30957004
Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model.Q33799732
TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?Q33913350
Lebrikizumab treatment in adults with asthmaQ34205683
Pulmonary radiation injuryQ34421890
Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatusQ35745429
Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function, prediction, and preventionQ36166696
Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune responseQ36370595
Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivoQ37163250
Role of type II pneumocyte senescence in radiation-induced lung fibrosisQ37209545
A novel and sensitive ELISA reveals that the soluble form of IL-13R-alpha2 is not expressed in plasma of healthy or asthmatic subjectsQ37221291
Radiation Pulmonary Toxicity: From Mechanisms to ManagementQ37777878
Tralokinumab, an anti-IL-13 mAb for the potential treatment of asthma and COPD.Q37820920
Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis.Q52543547
Allergy-driven alternative splicing of IL-13 receptor alpha2 yields distinct membrane and soluble forms.Q54570911
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherolQ73042279
Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cellsQ73827875
IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggsQ77899629
IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in miceQ79871786
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studiesQ81471173
Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responsesQ81550256
Enhanced expression of the decoy receptor IL-13Ralpha2 in macrophages of Schistosoma japonicum-infected miceQ84497430
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)39714
P577publication date2016-12-22
P1433published inScientific ReportsQ2261792
P1476titleIL-13 is a therapeutic target in radiation lung injury
P478volume6