Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression

scientific article published on 24 December 2010

Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10059-011-0008-8
P932PMC publication ID3906874
P698PubMed publication ID21193962

P50authorXun JinQ57020388
P2093author name stringDo-Hyun Nam
Sung-Hak Kim
Yun-Jaie Choi
Hyunggee Kim
Jinlong Yin
Samuel Beck
Sung-Chan Kim
Jun-Kyum Kim
Young-Woo Sohn
Xumin Pian
P2860cites workTelomerase modulates expression of growth-controlling genes and enhances cell proliferationQ73322990
TERT regulates cell survival independent of telomerase enzymatic activityQ74355604
Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancerQ77553578
Telomerase modulates Wnt signalling by association with target gene chromatinQ24310084
A distinct "side population" of cells with high drug efflux capacity in human tumor cellsQ24564100
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseQ27860541
Identification of human brain tumour initiating cellsQ27860921
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell linesQ29615823
Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer.Q33259358
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental programQ33315569
Functional multimerization of the human telomerase reverse transcriptaseQ33969441
Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor.Q34086792
Gliomagenesis: genetic alterations and mouse modelsQ34186001
Telomerase contributes to tumorigenesis by a telomere length-independent mechanismQ34188701
Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymomaQ34507174
Brain tumour stem cellsQ36488721
Telomerase therapeutics for cancer: challenges and new directionsQ36506309
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signalingQ36802989
Biology of glioma cancer stem cellsQ37572450
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screensQ39842716
Isolation and characterization of cancer stem like cells in human glioblastoma cell linesQ39881450
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.Q40479122
Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous liversQ45771270
TERT promotes cellular and organismal survival independently of telomerase activityQ46788573
Telomere shortening in gastric carcinoma with aging despite telomerase activationQ50664218
Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomasQ53471082
P433issue1
P921main subjectneoplastic stem cellsQ1638475
P304page(s)9-15
P577publication date2010-12-24
P1433published inMolecules and CellsQ12623193
P1476titleTelomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression
P478volume31

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cites work (P2860)
Q64898796A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells.
Q39294110Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation
Q35644577Association of TERT Polymorphisms with Clinical Outcome of Non-Small Cell Lung Cancer Patients
Q36562573Biological and clinical implications of cancer stem cells in primary brain tumors
Q38861997DNA methylation in adult diffuse gliomas
Q26853549EGFR Amplification and Glioblastoma Stem-Like Cells
Q47236669Fine‐mapping of a region of chromosome 5p15.33 (TERT‐CLPTM1L) suggests a novel locus in TERT and a CLPTM1L haplotype are associated with glioma susceptibility in a Chinese population
Q39165033FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells
Q38016280Glioblastoma cancer stem cells – From concept to clinical application
Q47118202Human glioma stem-like cells induce malignant transformation of bone marrow mesenchymal stem cells by activating TERT expression
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Q49442455Preclinical and clinical implications of TERT promoter mutation in glioblastoma multiforme
Q36959186Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.
Q38793244Progression inference for somatic mutations in cancer
Q37325708R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis
Q90749197TERT, a promoter of CNS malignancies
Q37395716Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression
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Q52662392When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.

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