The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA

scientific article published on July 1991

The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1991PNAS...88.6234D
P356DOI10.1073/PNAS.88.14.6234
P8608Fatcat IDrelease_oqzusgwk6jgghpmmpqloyn3zzi
P932PMC publication ID52057
P698PubMed publication ID2068104
P5875ResearchGate publication ID21088134

P2093author name stringSonenberg N
Roy S
Rosen CA
Reid L
Barnett R
Sumner-Smith M
Delling U
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Total chemical synthesis of a 77-nucleotide-long RNA sequence having methionine-acceptance activityQ24651950
Mutational analysis of the conserved basic domain of human immunodeficiency virus tat proteinQ24656004
Structural and functional characterization of human immunodeficiency virus tat proteinQ24656163
α-Helix–double helix interaction shown in the structure of a protamine-transfer RNA complex and a nucleoprotamine modelQ59087308
A region of basic amino-acid cluster in HIV-1 Tat protein is essential for trans-acting activity and nucleolar localizationQ64378953
Messenger RNA splicing in vitro: an excised intervening sequence and a potential intermediateQ64380630
Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous RevQ68505951
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activationQ68583028
A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiationQ69355887
The acidic amino-terminal region of the HIV-1 Tat protein constitutes an essential activating domainQ69366191
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cellsQ27860607
HIV-1 Tat protein trans-activates transcription in vitroQ30411837
Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virusQ33575002
Dimerization of the tat protein from human immunodeficiency virus: a cysteine-rich peptide mimics the normal metal-linked dimer interfaceQ33643113
A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeatQ33662926
Missense mutations in an infectious human immunodeficiency viral genome: functional mapping of tat and identification of the rev splice acceptorQ33681763
Sequence-specific interaction of Tat protein and Tat peptides with the transactivation-responsive sequence element of human immunodeficiency virus type 1 in vitroQ33900660
The trans-activator gene of HTLV-III is essential for virus replicationQ34161962
A second post-transcriptional trans-activator gene required for HTLV-III replicationQ34162178
Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating regionQ34284937
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitroQ34303073
Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNAQ34311433
Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear eventsQ34344850
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeatQ34563887
The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeatQ34564367
Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysisQ35226113
5'-3' exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesisQ35943171
Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.Q36802812
The art gene product of human immunodeficiency virus is required for replicationQ36827056
trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis.Q36832567
Regulation of expression of human immunodeficiency virusQ37783139
Tat and Rev: positive regulators of HIV gene expressionQ37947555
Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulationQ38345116
Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeatQ38346354
Effects of a highly basic region of human immunodeficiency virus Tat protein on nucleolar localizationQ40108559
Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeatQ40129795
A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activatorQ40650101
Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acidsQ41208182
HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structureQ41234955
HIV-1 tat trans-activation requires the loop sequence within tar.Q44349676
Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognitionQ44540333
The trans-activator gene of the human T cell lymphotropic virus type III is required for replicationQ44579665
Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elementsQ45040167
Fragments of the HIV-1 Tat protein specifically bind TAR RNA.Q45148606
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator proteinQ45830211
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).Q45838520
Tat protein from human immunodeficiency virus forms a metal-linked dimerQ45841752
Tat trans-activates the human immunodeficiency virus through a nascent RNA targetQ45847022
Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeatQ46674379
Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev functionQ58611466
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)6234-6238
P577publication date1991-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA
P478volume88

Reverse relations

cites work (P2860)
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