Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL

scientific article published on May 2007

Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1582-4934.2007.00042.X
P932PMC publication ID3922357
P698PubMed publication ID17635642
P5875ResearchGate publication ID6202109

P50authorSusan LogueQ43154766
P2093author name stringTimothy O'Brien
Afshin Samali
Thomas Ritter
Eva Szegezdi
Susan E Logue
Tríona Ní Chonghaile
Janice L V Reeve
P2860cites workCaspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3Q24324482
Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytesQ28564545
Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genesQ28582146
ER stress contributes to ischemia-induced cardiomyocyte apoptosisQ28584083
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies.Q31122965
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinQ33540751
CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.Q33736471
An induced proximity model for caspase-8 activation.Q34065853
Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?Q34511427
Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitroQ34551081
Many cuts to ruin: a comprehensive update of caspase substratesQ35091412
Ischemia/reperfusion injury at the intersection with cell death.Q35995674
Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease.Q36275682
Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.Q40279994
Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes.Q40576008
BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivoQ40615180
Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.Q41237683
Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytesQ42435182
Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic miceQ43572787
Endoplasmic Reticulum Stress Induces Apoptosis by an Apoptosome-dependent but Caspase 12-independent MechanismQ57274128
Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulationQ64378976
Adenovirus-mediated gene transfer of interleukin-4 to corneal endothelial cells and organ cultured corneas leads to high IL-4 expressionQ64381187
Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytesQ71641052
Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosisQ73678982
Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicinQ73975382
Apoptosis: cell death defined by caspase activationQ77921203
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
doxorubicinQ18936
mitochondrionQ39572
hypoxiaQ105688
P304page(s)509-520
P577publication date2007-05-01
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleDistinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL
P478volume11

Reverse relations

cites work (P2860)
Q37230844A standardized extract of Ginkgo biloba suppresses doxorubicin-induced oxidative stress and p53-mediated mitochondrial apoptosis in rat testes
Q37568721Acidic pre-conditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia
Q34639876Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment
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Q42269474Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis
Q42182706Cardiomyocyte-specific role of miR-24 in promoting cell survival
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Q33433158Complex patterns of mitochondrial dynamics in human pancreatic cells revealed by fluorescent confocal imaging
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Q34499932Differential functions of C- and N-terminal hepatitis B x protein in liver cells treated with doxorubicin in normoxic or hypoxic condition
Q37617357Drugs interfering with mitochondrial disorders
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