Taking STEPs forward to understand fragile X syndrome

scientific article published on January 2012

Taking STEPs forward to understand fragile X syndrome is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/978-3-642-21649-7_12
P932PMC publication ID3922766
P698PubMed publication ID22009355
P5875ResearchGate publication ID51727166

P2093author name stringPaul J Lombroso
Susan M Goebel-Goody
P2860cites workCorrection of fragile X syndrome in mice.Q22251255
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Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61Q24620404
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ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type IgammaQ24675779
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor traffickingQ24681745
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse modelQ26781974
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapsesQ28208647
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depressionQ28257629
A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structuresQ28260578
STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulumQ28300811
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndromeQ28302665
Regulation of NMDA receptor trafficking by amyloid-betaQ28506085
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signalingQ28567230
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEPQ28567752
Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampusQ28569108
A substrate trapping mutant form of striatal-enriched protein tyrosine phosphatase prevents amphetamine-induced stereotypies and long-term potentiation in the striatumQ28573319
Cellular and molecular characterization of a brain-enriched protein tyrosine phosphataseQ28574038
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticityQ28584848
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDQ28585633
The fragile X mental retardation protein inhibits translation via interacting with mRNAQ28588486
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptorsQ28771397
The mGluR theory of fragile X mental retardationQ29615060
Seizure susceptibility and mortality in mice that over-express amyloid precursor proteinQ30482779
The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdalaQ30498983
Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptorQ31451987
FMRP mediates mGluR5-dependent translation of amyloid precursor proteinQ33273636
Synaptic targeting by Alzheimer's-related amyloid beta oligomers.Q33288786
Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiationQ33288870
The structural era of endocytosisQ33683033
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatumQ33723743
Advances in understanding the molecular basis of FXTASQ33871325
Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndromeQ33953276
The ubiquitin-proteasome pathway and synaptic plasticityQ33994715
Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.Q34126102
Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatasesQ34289947
STEP regulation of seizure thresholds in the hippocampus.Q34680506
Mitogen-activated protein kinases in synaptic plasticity and memory.Q35803116
Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndromeQ36670213
The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.Q36980688
Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylationQ37252338
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.Q37387675
MPEP reduces seizure severity in Fmr-1 KO mice over expressing human AbetaQ37418819
Cell migration in the normal and pathological postnatal mammalian brainQ37476131
The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.Q37589711
Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmissionQ37632803
AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depressionQ39693283
Amyloid peptide attenuates the proteasome activity in neuronal cellsQ40375322
Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatumQ40949559
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptorsQ41825065
Tyrosine dephosphorylation regulates AMPAR internalisation in mGluR-LTD.Q42446128
Immunocytochemical localization of the striatal enriched protein tyrosine phosphatase in the rat striatum: a light and electron microscopic study with a complementary DNA-generated polyclonal antibodyQ42515643
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndromeQ42530481
Molecular determinants of NMDA receptor internalizationQ43690729
Internalization of ionotropic glutamate receptors in response to mGluR activationQ43785653
Protein composition of the intranuclear inclusions of FXTAS.Q44053371
Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spinesQ44199588
Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases.Q44969005
Glutamate receptor-interacting protein 1 protein binds to the microtubule-associated proteinQ45025438
Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR.Q45157608
NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout miceQ45349101
Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS).Q46007399
Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriersQ46124789
Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slicesQ46223156
Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brainQ46386576
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.Q46463850
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.Q46626541
Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression.Q46970980
Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight isoform of striatal enriched tyrosine phosphatase (STEP).Q47254738
STEP: a family of brain-enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoformsQ48051830
Early postnatal plasticity in neocortex of Fmr1 knockout miceQ48478142
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.Q48577748
Postnatal ontogeny of striatal-enriched protein tyrosine phosphatase (STEP) in rat striatumQ48713814
Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning.Q51074301
Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome.Q51891210
Audiogenic seizures susceptibility in transgenic mice with fragile X syndrome.Q51978092
Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP).Q52013286
Lateral organization of endocytic machinery in dendritic spines.Q52087997
Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP)Q73120747
Impaired proteasome function in Alzheimer's diseaseQ73897101
P921main subjectfragile X syndromeQ221472
P304page(s)223-241
P577publication date2012-01-01
P1433published inResults and problems in cell differentiationQ26842363
P1476titleTaking STEPs forward to understand fragile X syndrome
P478volume54

Reverse relations

cites work (P2860)
Q45957740Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome.
Q36925690Finding novel distinctions between the sAPPα-mediated anabolic biochemical pathways in Autism Spectrum Disorder and Fragile X Syndrome plasma and brain tissue
Q34435526Increasing our understanding of human cognition through the study of Fragile X Syndrome
Q39120013Lens Biology is a Dimension of Neurobiology
Q91613577Molecular Biomarkers in Fragile X Syndrome
Q36081738Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity
Q27023257Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes
Q26828004The function of metabotropic glutamate receptors in thalamus and cortex

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