A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity

scientific article published on 26 September 2013

A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/THY.2013.0127
P932PMC publication ID3926150
P698PubMed publication ID23668778
P5875ResearchGate publication ID236738714

P50authorBarbara CzarnockaQ48844600
Elizabeth Helen KempQ64873893
P2093author name stringBrian J Sutton
Ashley M Buckle
Monika Góra
Benjamin T Porebski
J Paul Banga
Marlena Godlewska
P2860cites workEndoproteolytic cleavage of human thyroperoxidase: role of the propeptide in the protein folding process.Q45182296
Exclusion of two major areas on thyroid peroxidase from the immunodominant region containing the conformational epitopes recognized by human autoantibodiesQ46568084
Key residues contributing to dominant conformational autoantigenic epitopes on thyroid peroxidase identified by mutagenesisQ47234758
Role of heme in intracellular trafficking of thyroperoxidase and involvement of H2O2 generated at the apical surface of thyroid cells in autocatalytic covalent heme bindingQ47851581
Evaluation of conformational epitopes on thyroid peroxidase by antipeptide antibody binding and mutagenesis.Q47927184
Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterized by molecular cloning of new transcripts with single- and multispliced mRNAs.Q48271969
A plasminogen-like protease in thyroid rough microsomes degrades thyroperoxidase and thyroglobulin.Q51799291
Structural insights into autoreactive determinants in thyroid peroxidase composed of discontinuous and multiple key contact amino acid residues contributing to epitopes recognized by patients' autoantibodies.Q51804167
Roles of heme insertion and the mannose-6-phosphate receptor in processing of the human myeloid lysosomal enzyme, myeloperoxidaseQ52477542
Mapping epitope specificities of monoclonal antibodies to thyroid peroxidase using recombinant antigen preparationsQ67534792
Calnexin and calreticulin binding to human thyroperoxidase is required for its first folding step(s) but is not sufficient to promote efficient cell surface expressionQ73500669
Immunoglobulin G kappa antithyroid peroxidase antibodies in Hashimoto's thyroiditis: epitope-mapping analysisQ73578124
Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidaseQ73832160
Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: analysis of protein expression in Graves' thyroid tissueQ73853126
Localization of the thyroid peroxidase autoantibody immunodominant region to a junctional region containing portions of the domains homologous to complement control protein and myeloperoxidaseQ74588339
Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAsQ24298977
Molecular heterogeneity and alternative splicing of human lactoperoxidaseQ24322001
Crystal structure of calcium-independent subtilisin BPN' with restored thermal stability folded without the prodomainQ27749440
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Clustal W and Clustal X version 2.0Q27860517
GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular SimulationQ27860944
Structural and functional aspects of thyroid peroxidaseQ28267047
Intracellular trafficking of thyroid peroxidase to the cell surfaceQ28575656
Protein disorder prediction: implications for structural proteomicsQ29615736
Roles of N-linked glycans in the endoplasmic reticulumQ29616458
Comparative protein structure modeling using MODELLERQ29617493
A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6Q29617517
Intramolecular chaperones: polypeptide extensions that modulate protein folding.Q30326436
Protein annotation and modelling servers at University College LondonQ30389763
Search for the autoantibody immunodominant region on thyroid peroxidase: epitopic footprinting with a human monoclonal autoantibody locates a facet on the native antigen containing a highly conformational epitopeQ31806754
Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodiesQ33203023
Biosynthesis, processing, and sorting of human myeloperoxidaseQ33223927
Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organQ34110011
Analysis of immunoglobulin G kappa antithyroid peroxidase antibodies from different tissues in Hashimoto's thyroiditisQ36889894
Thyroid peroxidase as an autoantigenQ36932723
The intramolecular chaperone-mediated protein foldingQ37313532
Golgi linked protein glycosylation and associated diseasesQ37512679
Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membraneQ38341016
Competition between calnexin and BiP in the endoplasmic reticulum can lead to the folding or degradation of human thyroperoxidase.Q40271551
Localization of the discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseasesQ40681167
Sorting for storage in myeloid cells of nonmyeloid proteins and chimeras with the propeptide of myeloperoxidase precursorQ40753926
Cell type-dependent differences in thyroid peroxidase cell surface expressionQ40864501
Lysosomal segregation of a mannose-rich glycoprotein imparted by the prosequence of myeloperoxidaseQ41001717
Human thyroperoxidase is largely retained and rapidly degraded in the endoplasmic reticulum. Its N-glycans are required for folding and intracellular traffickingQ41006512
The role of the propeptide for processing and sorting of human myeloperoxidaseQ41059058
Human thyroid peroxidase-myeloperoxidase chimeric molecules: tools for the study of antigen recognition by thyroid peroxidase autoantibodiesQ41059809
Degradation of human thyroperoxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the proteinQ41921953
The quest for the autoantibody immunodominant region on thyroid peroxidase: guided mutagenesis based on a hypothetical three-dimensional modelQ42628233
Relationship between immunological structure and biochemical properties of human thyroid peroxidase.Q44574618
P433issue2
P921main subjectimmunologyQ101929
P304page(s)371-382
P577publication date2013-09-26
P1433published inThyroidQ15709940
P1476titleA redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity
P478volume24

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cites work (P2860)
Q52364453Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines.
Q50167687Biosynthesis of human myeloperoxidase
Q38921047Challenges in the Standardization of Autoantibody Testing: a Comprehensive Review
Q56990425Chemie und Biologie der Schilddrüsenhormon-Biosynthese und -Wirkung
Q38844606Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones
Q36249212Establishment of the upper reference limit for thyroid peroxidase autoantibodies according to the guidelines proposed by the National Academy of Clinical Biochemistry: comparison of five different automated methods
Q64916761H2O2 Metabolism in Normal Thyroid Cells and in Thyroid Tumorigenesis: Focus on NADPH Oxidases.
Q38139409Lactoperoxidase: structural insights into the function,ligand binding and inhibition.
Q35856798Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity
Q64107374Mutation Spectrum in TPO Gene of Bangladeshi Patients with Thyroid Dyshormonogenesis and Analysis of the Effects of Different Mutations on the Structural Features and Functions of TPO Protein through Approach
Q58695460Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?

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