Biosynthesis of human myeloperoxidase

scientific article published on 3 February 2018

Biosynthesis of human myeloperoxidase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.ABB.2018.02.001
P932PMC publication ID5967637
P698PubMed publication ID29408362

P2093author name stringWilliam M Nauseef
P2860cites workMultiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylationQ24293821
Molecular heterogeneity and alternative splicing of human lactoperoxidaseQ24322001
Inactivation of human myeloperoxidase by hydrogen peroxideQ24336078
Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3Q24678301
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeastQ24685400
Disulfide bond formation in the mammalian endoplasmic reticulumQ26829235
X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolutionQ27622235
Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolutionQ27636172
Essential Role of Proximal Histidine-Asparagine Interaction in Mammalian PeroxidasesQ27656492
Prediction of proprotein convertase cleavage sitesQ28246994
Structural and functional aspects of thyroid peroxidaseQ28267047
The peroxidase-cyclooxygenase superfamily: Reconstructed evolution of critical enzymes of the innate immune systemQ28267278
Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromesQ28359694
Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidaseQ28610241
Processing and targeting of granule proteins in human neutrophilsQ28611911
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ERQ29615171
Roles of N-linked glycans in the endoplasmic reticulumQ29616458
Biosynthesis, processing, and sorting of human myeloperoxidaseQ33223927
Myeloperoxidase gene expression and regulation by myeloid cell growth factors in normal and leukemic cellsQ33536303
Association of myeloperoxidase with ovarian cancerQ33689246
Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturationQ33705499
Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activityQ33855320
Heme to protein linkages in mammalian peroxidases: impact on spectroscopic, redox and catalytic propertiesQ34004418
Myeloperoxidase and cardiovascular disease.Q34406359
Myeloperoxidase in human neutrophil host defenceQ34994685
Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease.Q35070529
The human myeloperoxidase gene is regulated by LXR and PPARalpha ligandsQ35697554
Statins downregulate myeloperoxidase gene expression in macrophagesQ46454816
Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's diseaseQ46454909
The role of the sulfonium linkage in the stabilization of the ferrous form of myeloperoxidase: a comparison with lactoperoxidaseQ46688254
The potentiation of myeloperoxidase activity by the glycosaminoglycan-dependent binding of myeloperoxidase to proteins of the extracellular matrixQ46792546
How Are Proteins Reduced in the Endoplasmic Reticulum?Q47387477
Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndromeQ47688030
Role of heme in intracellular trafficking of thyroperoxidase and involvement of H2O2 generated at the apical surface of thyroid cells in autocatalytic covalent heme bindingQ47851581
No association of G-463A myeloperoxidase gene polymorphism with MPO-ANCA-associated vasculitisQ47924858
Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosisQ48615832
Calreticulin biosynthesis and processing in human myeloid cells: demonstration of signal peptide cleavage and N-glycosylation.Q48676547
Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population.Q51481854
Developmental and differential regulation of human MPO gene in leukemic cells.Q52240965
Roles of heme insertion and the mannose-6-phosphate receptor in processing of the human myeloid lysosomal enzyme, myeloperoxidaseQ52477542
The post-translational processing of myeloperoxidase is regulated by the availability of heme.Q52513323
Impact of two novel mutations on the structure and function of human myeloperoxidase.Q52580644
Characterization of a new human diploid myeloid leukemia cell line (PLB-985) with granulocytic and monocytic differentiating capacity.Q52834010
Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study.Q53256331
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection.Q54284525
Redox Thermodynamics of the Fe(III)/Fe(II) Couple of Human Myeloperoxidase in Its High-Spin and Low-Spin Forms†Q59400071
Processing and Maturation of Flavocytochromeb558Include Incorporation of Heme as a Prerequisite for Heterodimer AssemblyQ59942392
Evidence for difference in the roles of two cysteine residues involved in disulfide bond formation in the folding of human lysozymeQ67287289
Ultrastructural, immunochemical, and cytochemical study of myeloperoxidase in myeloid leukemia HL-60 cells following treatment with succinylacetone, an inhibitor of heme biosynthesisQ67853406
Alteration of N-terminal residues of mature human lysozyme affects its secretion in yeast and translocation into canine microsomal vesiclesQ68041016
Folding of human lysozyme in vivo by the formation of an alternative disulfide bondQ68214845
Isolation and characterization of extracellular myeloperoxidase precursor in HL-60 cell culturesQ68448606
Assembly of dimeric myeloperoxidase during posttranslational maturation in human leukemic HL-60 cellsQ68458356
Expression and characterization of recombinant human eosinophil peroxidase. Impact of the R286H substitution on the biosynthesis and activity of the enzymeQ40874944
Myeloid cell-lineage and premylocytic-stage-specific- expression of themouse myeloperoxidase gene is controlled at initiation as well as elongation levels of transcriptionQ40939975
Recombinant human thyroid peroxidase expressed in insect cells is soluble at high concentrations and forms diffracting crystalsQ40967071
Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum.Q40975170
Lysosomal segregation of a mannose-rich glycoprotein imparted by the prosequence of myeloperoxidaseQ41001717
Human thyroperoxidase is largely retained and rapidly degraded in the endoplasmic reticulum. Its N-glycans are required for folding and intracellular traffickingQ41006512
The role of the propeptide for processing and sorting of human myeloperoxidaseQ41059058
Human thyroid peroxidase-myeloperoxidase chimeric molecules: tools for the study of antigen recognition by thyroid peroxidase autoantibodiesQ41059809
Identification and functional analysis of multiple murine myeloperoxidase (MPO) promoters and comparison with the human MPO promoter regionQ41142618
Uptake of recombinant myeloperoxidase, free or fused to Fc gamma, by macrophages enhances killing activity toward micro-organismsQ41180268
Gender-specific protective effect of the -463G>A polymorphism of myeloperoxidase gene against the risk of essential hypertension in Russians.Q41269692
Myeloperoxidase biosynthesis by a human promyelocytic leukemia cell line: insight into myeloperoxidase deficiency.Q41364822
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoproteaseQ41505675
Myeloperoxidase is synthesized as larger phosphorylated precursorQ41584280
Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiationQ41674871
Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell linesQ41684451
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulumQ41810951
Posttranslational processing of a human myeloid lysosomal protein, myeloperoxidaseQ41913250
Processing of a newly identified intermediate of human myeloperoxidase in isolated granules occurs at neutral pH.Q41915348
The processing and intracellular transport of myeloperoxidase. Modulation by lysosomotropic agents and monensinQ41916280
Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factorQ41958552
Myeloperoxidase Selectively Binds and Selectively Kills MicrobesQ42044032
Biosynthesis, transport and processing of myeloperoxidase in the human leukaemic promyelocytic cell line HL-60 and normal marrow cellsQ42848385
Evidence for the involvement of an acidic compartment in the processing of myeloperoxidase in human promyelocytic leukemia HL-60 cellsQ43496514
Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox).Q43645354
Evidence for intramolecular disulfide bond shuffling in the folding of mutant human lysozymeQ44682382
Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphismQ44688340
Endoproteolytic cleavage of human thyroperoxidase: role of the propeptide in the protein folding process.Q45182296
Molecular cloning of the structural gene for porcine thyroid peroxidase.Q45977195
Autocatalytic processing of heme by lactoperoxidase produces the native protein-bound prosthetic group.Q46031301
Disulfide bond acquisition through eukaryotic protein evolution.Q46378790
Chromosomal localization of the human myeloperoxidase gene by in situ hybridization using oligonucleotide probesQ68492000
Rat thyroid peroxidase (TPO) biosynthesis in vitro: studies using antiserum to porcine TPOQ69020818
Uptake and utilization of human polymorphonuclear leukocyte granule myeloperoxidase by mouse peritoneal macrophagesQ69356827
Myeloperoxidase: its structure and expression during myeloid differentiationQ70077629
Purification of eosinophil peroxidase and studies of biosynthesis and processing in human marrow cellsQ70104327
Comparison of myeloperoxidase and hemi-myeloperoxidase with respect to catalysis, regulation, and bactericidal activityQ70189331
Regulation of myeloperoxidase gene expression during differentiation of human myeloid leukemia HL-60 cellsQ70191728
Sequence comparison of putative regulatory DNA of the 5' flanking region of the myeloperoxidase gene in normal and leukemic bone marrow cellsQ70474929
Phagocytosis and intracellular killing of Candida albicans by macrophages exposed to myeloperoxidaseQ71071353
Control of myeloperoxidase gene expression in developing myeloid cellsQ71874667
Identification and characterization of the human myeloperoxidase promoterQ72285480
The effects of GM-CSF on myeloperoxidase release in normal and myelodysplastic neutrophilsQ72623101
Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophanQ72664523
An analysis of the structure and antigenicity of different forms of human thyroid peroxidaseQ72701025
Myeloperoxidase precursors in human myeloid leukemia HL-60 cellsQ72929875
Purification and crystallisation of the autoantigen thyroid peroxidase from human Graves' thyroid tissueQ73401322
Calnexin and calreticulin binding to human thyroperoxidase is required for its first folding step(s) but is not sufficient to promote efficient cell surface expressionQ73500669
The propeptide of the transforming growth factor-beta superfamily member, macrophage inhibitory cytokine-1 (MIC-1), is a multifunctional domain that can facilitate protein folding and secretionQ73693575
An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemiaQ73774804
Biochemical and molecular characterization of hereditary myeloperoxidase deficiencyQ73838814
Functional activity of three distinct myeloperoxidase (MPO) promoters in human myeloid cellsQ74213162
Coordinated participation of calreticulin and calnexin in the biosynthesis of myeloperoxidaseQ74326152
Folding pathway mediated by an intramolecular chaperone: propeptide release modulates activation precision of pro-subtilisinQ74568466
Insights into myeloperoxidase biosynthesis from its inherited deficiencyQ77392337
A pathway for conformational diversity in proteins mediated by intramolecular chaperonesQ77772325
An association study of two functional promotor polymorphisms in the myeloperoxidase (MPO) gene in multiple sclerosisQ80573212
Revealing binding sites for myeloperoxidase on the surface of human low density lipoproteinsQ82338554
Congenital goitrous hypothyroidism: mutation analysis in the thyroid peroxidase geneQ85058197
Role of quality control pathways in human diseases involving protein misfoldingQ35703293
Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and AutoantigenicityQ35856798
Risk prediction with serial myeloperoxidase monitoring in patients with acute chest pain.Q35909357
T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond FormationQ35927277
Lessons from MPO deficiency about functionally important structural features.Q35928947
Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulumQ36220222
Proconvertase proteolytic processing of an enzymatically active myeloperoxidase precursorQ36282271
Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulumQ36391681
Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysisQ36737121
The activation and physiological functions of the proprotein convertasesQ37110934
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans.Q37281608
Myeloperoxidase, modified lipoproteins, and atherogenesisQ37353408
A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradationQ37383836
Processing of peptide and hormone precursors at the dibasic cleavage sitesQ37419008
Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particleQ37431348
Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cellsQ37523376
A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activityQ37587910
Genetics and phenomics of hypothyroidism and goiter due to TPO mutationsQ37691933
PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease: A meta-analysis of 4744 subjectsQ37727318
Disulfide bonds: protein folding and subcellular protein traffickingQ38010794
Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular diseaseQ38028558
Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signalingQ38155661
Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in CellsQ38291721
Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membraneQ38341016
An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response elementQ38356635
Granulopoiesis and granules of human neutrophils.Q38936489
Biosynthesis and processing of myeloperoxidase--a marker for myeloid cell differentiationQ39184688
Association between myeloperoxidase G-463A polymorphism and lung cancer riskQ39367333
Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.Q39522439
Myeloperoxidase G-463A polymorphism and the risk of gastric cancer: a case-control studyQ39761692
Exogenous myeloperoxidase enhances bacterial phagocytosis and intracellular killing by macrophagesQ39822676
Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population StudyQ40196845
Competition between calnexin and BiP in the endoplasmic reticulum can lead to the folding or degradation of human thyroperoxidase.Q40271551
Iodination of thyroglobulin. An intracellular or extracellular process?Q40318079
Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality controlQ40597954
Myeloperoxidase gene expression in normal granulopoiesis and acute leukemiasQ40599143
Intramolecular chaperones and protein foldingQ40620151
Sorting for storage in myeloid cells of nonmyeloid proteins and chimeras with the propeptide of myeloperoxidase precursorQ40753926
Asp-225 and glu-375 in autocatalytic attachment of the prosthetic heme group of lactoperoxidaseQ40760790
A transient kinetic study on the reactivity of recombinant unprocessed monomeric myeloperoxidaseQ40785074
P407language of work or nameEnglishQ1860
P577publication date2018-02-03
P1433published inArchives of Biochemistry and BiophysicsQ635818
P1476titleBiosynthesis of human myeloperoxidase

Reverse relations

cites work (P2860)
Q88956461Antimicrobial actions of dual oxidases and lactoperoxidase
Q64764525Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairmen
Q57815421Role of inflammatory cells in airway remodeling in COPD

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