| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Anna Taylor | Q43147026 |
| P2093 | author name string | Catherine M Cahill | |
| Christopher J Evans | |||
| Amynah A A Pradhan | |||
| Wendy Walwyn | |||
| P2860 | cites work | Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine | Q40777843 |
| Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene | Q41157124 | ||
| Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats | Q41573401 | ||
| The Role of TNFα in the Periaqueductal Gray During Naloxone-Precipitated Morphine Withdrawal in Rats | Q42182469 | ||
| Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers | Q42705103 | ||
| Serine 363 of the {delta}-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands | Q42794627 | ||
| Autoimmunovascular regulation: morphine and anandamide and ancondamide stimulated nitric oxide release | Q43070990 | ||
| Differential tolerance to antinociceptive effects of mu opioids during repeated treatment with etonitazene, morphine, or buprenorphine in rats | Q43583543 | ||
| Opiate dependence induces network state shifts in the limbic system | Q43680892 | ||
| Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes | Q43865370 | ||
| Widespread but regionally specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus, and neocortex of adult rats | Q44175285 | ||
| Acute opioid withdrawal is associated with increased neural activity in reward-processing centers in healthy men: A functional magnetic resonance imaging study | Q44330127 | ||
| Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. | Q44334988 | ||
| Cellular morphine tolerance produced by βarrestin-2-dependent impairment of μ-opioid receptor resensitization. | Q44350690 | ||
| Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization. | Q44580806 | ||
| Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area | Q44733402 | ||
| Comparative proteomic analysis of the nucleus accumbens during extinction and reinstatement of morphine dependence | Q44898368 | ||
| Effects of morphine withdrawal on the membrane properties of medium spiny neurons in the nucleus accumbens shell | Q45173316 | ||
| Morphine side effects in beta-arrestin 2 knockout mice | Q46510708 | ||
| Temporal and anatomic patterns of immediate-early gene expression in the forebrain of C57BL/6 and DBA/2 mice after morphine administration | Q46828823 | ||
| Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward | Q46949674 | ||
| Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation. | Q47928380 | ||
| Blockage of acquisition and expression of morphine-induced conditioned place preference in rats due to activation of glutamate receptors type II/III in nucleus accumbens | Q48130903 | ||
| Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal. | Q48274815 | ||
| Enhanced stimulus-reward learning by intra-amygdala administration of a D3 dopamine receptor agonist | Q48598613 | ||
| Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal | Q48629573 | ||
| Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission. | Q48717775 | ||
| Activation of p38 signaling in the microglia in the nucleus accumbens contributes to the acquisition and maintenance of morphine-induced conditioned place preference. | Q48832798 | ||
| Cannabinoid receptors in the basolateral amygdala are involved in the potentiation of morphine rewarding properties in the acquisition, but not expression of conditioned place preference in rats. | Q50671268 | ||
| Withdrawal from chronic amphetamine reduces dopamine transmission in the rat lateral septum. | Q52304525 | ||
| Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion | Q59080348 | ||
| Heroin "overdose" death: contribution of drug-associated environmental cues | Q70675706 | ||
| A novel role of spinal astrocytic connexin 43: mediating morphine antinociceptive tolerance by activation of NMDA receptors and inhibition of glutamate transporter-1 in rats | Q87442426 | ||
| Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2 | Q24305533 | ||
| Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats | Q24598800 | ||
| The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia | Q24650739 | ||
| Neurobiology of opioid dependence in creating addiction vulnerability | Q26742048 | ||
| Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies | Q26749305 | ||
| Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective | Q26828594 | ||
| Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward | Q27305210 | ||
| VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons | Q27311469 | ||
| Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit | Q27319741 | ||
| Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies | Q28210337 | ||
| The role of the habenula in drug addiction. | Q28238267 | ||
| Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons | Q28267475 | ||
| Representation of negative motivational value in the primate lateral habenula | Q28302261 | ||
| Lateral habenula as a source of negative reward signals in dopamine neurons | Q28303742 | ||
| Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal | Q28483614 | ||
| A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine | Q28580405 | ||
| Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra | Q28581975 | ||
| Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence | Q28590279 | ||
| BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain | Q29616106 | ||
| What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | Q29618655 | ||
| Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity | Q30435816 | ||
| An anatomical basis for opponent process mechanisms of opiate withdrawal | Q30472851 | ||
| beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2. | Q30494324 | ||
| The role of ubiquitination in lysosomal trafficking of δ-opioid receptors | Q30499514 | ||
| Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively. | Q39381189 | ||
| A two-separate-motivational-systems hypothesis of opioid addiction | Q39451311 | ||
| Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation | Q39646963 | ||
| Acquisition of morphine conditioned place preference increases the dendritic complexity of nucleus accumbens core neurons | Q40290304 | ||
| Disentangling pleasure from incentive salience and learning signals in brain reward circuitry | Q30502236 | ||
| Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning | Q30505951 | ||
| Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking | Q30544911 | ||
| Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward | Q33559498 | ||
| Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia | Q33754272 | ||
| Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal | Q33811040 | ||
| BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions | Q33906351 | ||
| GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems | Q33939402 | ||
| Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2. | Q34065061 | ||
| Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance | Q34154223 | ||
| Expression of mu opioid receptor in dorsal diencephalic conduction system: new insights for the medial habenula. | Q34183878 | ||
| Opioid activation of toll-like receptor 4 contributes to drug reinforcement | Q34294203 | ||
| BDNF is a negative modulator of morphine action | Q34304358 | ||
| The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics. | Q34311504 | ||
| Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning | Q34345631 | ||
| Glial TLR4 signaling does not contribute to opioid-induced depression of respiration | Q34353901 | ||
| Chloride extrusion enhancers as novel therapeutics for neurological diseases | Q34375595 | ||
| Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition | Q34393092 | ||
| Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids | Q34399068 | ||
| Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting". | Q34411031 | ||
| Kappa Antagonist JDTic in Phase 1 Clinical Trial | Q34485042 | ||
| β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons. | Q34939769 | ||
| Reduced LTP and LTD in prefrontal cortex synapses in the nucleus accumbens after heroin self-administration | Q35146736 | ||
| Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. | Q35585783 | ||
| Microglia disrupt mesolimbic reward circuitry in chronic pain. | Q35675189 | ||
| Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression | Q35676825 | ||
| Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms | Q35822876 | ||
| Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice | Q35980825 | ||
| Pain Among High-Risk Patients on Methadone Maintenance Treatment | Q36016599 | ||
| Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling. | Q36035962 | ||
| Mechanism and consequences of delta-opioid receptor internalization | Q36322172 | ||
| Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behavior | Q36335668 | ||
| Dynorphin, Dysphoria, and Dependence: the Stress of Addiction | Q36366791 | ||
| Ligand-directed signalling within the opioid receptor family | Q36382935 | ||
| How does stress-induced activation of the kappa opioid system increase addiction risk? | Q36384633 | ||
| Enkephalin Disinhibits Mu Opioid Receptor-Rich Striatal Patches via Delta Opioid Receptors | Q36423894 | ||
| Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement | Q36498162 | ||
| Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine | Q36565595 | ||
| Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. | Q36591603 | ||
| Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens | Q36713932 | ||
| Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function | Q36718661 | ||
| Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. | Q36736335 | ||
| Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems | Q36744366 | ||
| A thalamic input to the nucleus accumbens mediates opiate dependence | Q36745935 | ||
| Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats | Q36932893 | ||
| Molecular mechanisms of opioid receptor-dependent signaling and behavior | Q36974487 | ||
| Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction | Q37020138 | ||
| Addiction and the brain antireward system | Q37043564 | ||
| Molecular Pharmacology of δ-Opioid Receptors | Q37062556 | ||
| GPCR signaling along the endocytic pathway | Q37141950 | ||
| Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis | Q37152999 | ||
| Addiction as a stress surfeit disorder. | Q37315976 | ||
| Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons | Q37316191 | ||
| A novel noncanonical signaling pathway for the μ-opioid receptor | Q37325629 | ||
| Transducing neuronal activity into dendritic spine morphology: new roles for p38 MAP kinase and N-cadherin | Q37393562 | ||
| Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway. | Q37409861 | ||
| The glutamate homeostasis hypothesis of addiction | Q37538517 | ||
| The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors | Q37589122 | ||
| Delta and kappa opioid receptors as suitable drug targets for pain | Q37660843 | ||
| Opiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons | Q38023866 | ||
| Negative reinforcement in drug addiction: the darkness within | Q38102814 | ||
| Opioid tolerance--a predictor of increased length of stay and higher readmission rates | Q38233087 | ||
| Does the kappa opioid receptor system contribute to pain aversion? | Q38276410 | ||
| Understanding opioid reward | Q38338668 | ||
| Mesolimbic dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction | Q38707324 | ||
| Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition | Q38777981 | ||
| Delta-opioid receptors as targets for migraine therapy | Q38792542 | ||
| P433 | issue | 11 | |
| P921 | main subject | opioid | Q427523 |
| desensitization | Q2700499 | ||
| P304 | page(s) | 963-976 | |
| P577 | publication date | 2016-09-23 | |
| P1433 | published in | Trends in Pharmacological Sciences | Q2451474 |
| P1476 | title | Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation | |
| P478 | volume | 37 |
| Q52715368 | Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance. |
| Q43075846 | Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons |
| Q43075987 | Designing Safer Analgesics via μ-Opioid Receptor Pathways |
| Q92642511 | Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome |
| Q92256538 | Enhancing Natural Reward Responsiveness Among Opioid Users Predicts Chronic Pain Relief: EEG Analyses From a Trial of Mindfulness-Oriented Recovery Enhancement |
| Q90185275 | Improved efficacy, tolerance, safety and abuse liability profile of the combination CR4056-morphine over morphine alone in rodent models |
| Q44347110 | Ligand-Directed Signaling at the Delta Opioid Receptor |
| Q60920772 | Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice |
| Q41605692 | Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide. |
| Q47314731 | Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats. |
| Q90288944 | Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect |
| Q89207660 | Opioid receptors: drivers to addiction? |
| Q90443281 | Opioid-Induced Tolerance and Hyperalgesia |
| Q89946431 | Opioids: keeping the good, eliminating the bad |
| Q93090641 | Pain And Opioid Systems, Implications In The Opioid Epidemic |
| Q36336144 | Specific behavioral and cellular adaptations induced by chronic morphine are reduced by dietary omega-3 polyunsaturated fatty acids. |
| Q50026534 | Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway. |
| Q44342560 | Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice. |
| Q90107822 | The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models |
| Q60654220 | The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence |
| Q44350091 | [EXPRESS] Usefulness for the combination of G-protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance |
Search more.