Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene (scientific article published on October 1996)

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Q44347649	Etorphines: mu-opioid receptor-selective antinociception and low physical dependence capacity
Q36534236	Evaluation of anti-inflammatory and analgesic activities of extracts from herb of Chelidonium majus L.
Q33395205	Expansion of the human mu-opioid receptor gene architecture: novel functional variants
Q48525218	Experimental Models Combining Traumatic Brain Injury and Hypoxia
Q34970664	Experimental genetic approaches to addiction.
Q100454224	Exploring the activation pathway and Gi-coupling specificity of the μ-opioid receptor
Q34641459	Exploring the opioid system by gene knockout
Q34183878	Expression of mu opioid receptor in dorsal diencephalic conduction system: new insights for the medial habenula.
Q44352056	Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS: a 33P in situ hybridization study
Q44938371	Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine.
Q35853978	Expression of the μ, κ, and δ-opioid receptors and tyrosine hydroxylase in MN9D cells
Q44332619	Extensive overlap of mu-opioid and nicotinic sensitivity in cortical interneurons.
Q37405419	FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor.
Q46743401	Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains
Q43226849	Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity
Q48589684	Foster mother care but not prenatal morphine exposure enhances cocaine self-administration in young adult male and female rats.
Q55317223	Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
Q37249905	Functional characterization of human variants of the mu-opioid receptor gene
Q33873664	Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.
Q84630457	Functional imaging in pain research
Q43662870	Functional interaction between opioid and cannabinoid receptors in drug self-administration.
Q41843746	Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.
Q35682949	G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice.
Q38340269	G protein-coupled receptors: functional and mechanistic insights through altered gene expression
Q44341092	G-protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice
Q37836762	Galanin and addiction
Q40861559	Gene disruption in mice: models of development and disease
Q47232230	Generation and Characterization of Antibodies against Opioid Receptors from Zebrafish.
Q49052189	Generation of dynorphin knockout mice
Q34076144	Genes and addiction
Q35682961	Genes associated with addiction: alcoholism, opiate, and cocaine addiction
Q47934009	Genetic dissociation of morphine analgesia from hyperalgesia in mice
Q48808995	Genetic variation in heroin-induced changes in behaviour: effects of B6 strain dose on conditioned reward and locomotor sensitization in 129-B6 hybrid mice
Q77147080	Genetics of alcohol and other abused drugs
Q35381687	Genotyping test with clinical factors: better management of acute postoperative pain?
Q38893386	Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse.
Q43076075	Glial and neuroinflammatory targets for treating substance use disorders
Q34158930	Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis
Q28143344	Heterodimerization of mu and delta opioid receptors: A role in opiate synergy
Q59335423	Heteromerization Modulates mu Opioid Receptor Functional Properties
Q24630645	Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics
Q34939624	Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities
Q58274661	Higher frequency of C.3435 of the ABCB1 gene in patients with tramadol dependence disorder
Q60089151	How does morphine work?
Q34144947	How to design an opioid drug that causes reduced tolerance and dependence
Q43797993	Hypericum perforatum inhibits the binding of mu- and kappa-opioid receptor expressed with the Semliki Forest virus system
Q53467516	I don't want to see the pictures: science writing and the visibility of animal experiments.
Q41809990	Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor
Q34354902	Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity
Q44068278	Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors
Q33594412	Identifying genes for alcohol and drug sensitivity: recent progress and future directions
Q36414746	Impact of chronic morphine on delta opioid receptor-expressing neurons in the mouse hippocampus
Q24605833	Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine
Q44342854	Impaired water maze learning performance in mu-opioid receptor knockout mice
Q34358797	Implications of genome wide association studies for addiction: are our a priori assumptions all wrong?
Q44333359	Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
Q24656000	Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter
Q47256037	In silico studies of conformational dynamics of Mu opioid receptor performed using gaussian accelerated molecular dynamics
Q88030717	In vitro and in vivo functional profile characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3-carboxamido)morphinan (NAQ) as a low efficacy mu opioid receptor modulator
Q36358677	In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance.
Q34763622	In vivo activation of a mutant mu-opioid receptor by antagonist: future direction for opiate pain treatment paradigm that lacks undesirable side effects
Q44348499	In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance
Q36670065	In vivo regulation of the μ opioid receptor: role of the endogenous opioid agents
Q31887588	Incomplete cross tolerance and multiple mu opioid peptide receptors
Q42081407	Increased abundance of opioid receptor heteromers after chronic morphine administration
Q34124840	Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene
Q42734773	Increased rewarding properties of morphine in dopamine-transporter knockout mice
Q74133683	Increased sensitivity to the stimulant effects of morphine conferred by anti-adhesive glycoprotein SPARC in amygdala
Q46702686	Induction of morphine-6-glucuronide synthesis by heroin self-administration in the rat.
Q62818488	Inflammation-associated changes in DOR expression and function in the mouse colon
Q36734927	Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain
Q35653788	Inflammatory pain is enhanced in delta opioid receptor-knockout mice
Q44350218	Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors.
Q37998313	Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain
Q36528515	Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor
Q44349304	Inhibition of morphine tolerance and dependence by diazepam and its relation to mu-opioid receptors in the rat brain and spinal cord
Q40749868	Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin
Q38968515	Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain
Q30828780	Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play.
Q43621525	Interaction between morphine and lysine
Q74088870	Interaction between the retinoid X receptor and transcription factor IIB is ligand-dependent in vivo
Q24302002	Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence
Q35053193	Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Q34197724	Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na⁺ influx, mitochondrial instability, and Ca²⁺ overload.
Q40650863	Internalization and recycling of human μ opioid receptors expressed in Sf9 insect cells
Q89804175	Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system
Q43639942	Intraperitoneal injection of antisense peptide nucleic acids targeted to the mu receptor decreases response to morphine and receptor protein levels in rat brain
Q34128898	Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm.
Q40798197	Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.
Q44349824	Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model
Q37140009	Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
Q44340949	Involvement of kappa-opioid receptors in peripheral response to nerve stimulation in kappa-opioid receptor knockout mice
Q46790397	Involvement of kappa/dynorphin system in the development of tolerance to nicotine-induced antinociception
Q35676840	Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons
Q74636613	Isolation and characterization of natural human IgG with a morphine-like activity
Q30437184	It's MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system
Q35580750	Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation
Q37559088	Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration
Q48313189	Knock-in mice reveal nonsense-mediated mRNA decay in the brain.
Q41835138	Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons
Q44182704	Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.
Q44334234	Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice
Q35765802	Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP-, DOP-, and KOP-opioid receptor knockout mice of three different genetic backgrounds
Q44050781	Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice.
Q44346657	Lack of social exploratory activation in male μ-opioid receptor KO mice in response to playback of female ultrasonic vocalizations
Q28591699	Lack of the nociceptin receptor does not affect acute or chronic nociception in mice
Q38022011	Let-7 microRNAs and Opioid Tolerance
Q90083198	Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks
Q33952880	Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling
Q28477403	Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target
Q36382935	Ligand-directed signalling within the opioid receptor family
Q36780862	Ligand-induced μ opioid receptor internalization in enteric neurons following chronic treatment with the opiate fentanyl
Q82603670	Localization of endogenous morphine-like compounds in the mouse spinal cord
Q74072579	Localization of endomorphin-2-like immunoreactivity in the rat medulla and spinal cord
Q40946137	Localization of promoter elements in the human mu-opioid receptor gene and regulation by DNA methylation
Q73305013	Long-lasting antinociceptive effect of DAMGO chloromethyl ketone in rats
Q42702528	Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain
Q33993802	Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.
Q44234620	Loss of mu-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of mu-opioid receptor gene
Q37393641	Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
Q37629809	Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia
Q34330604	Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine.
Q24307686	MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens
Q78056910	MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli
Q44350404	MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions
Q37084008	Management of opioid analgesic overdose
Q42486161	Mapping of endogenous morphine-like compounds in the adult mouse brain: Evidence of their localization in astrocytes and GABAergic cells.
Q44350124	Maternal exposure to delta9-tetrahydrocannabinol facilitates morphine self-administration behavior and changes regional binding to central mu opioid receptors in adult offspring female rats
Q33183067	Measuring pain in the (knockout) mouse: big challenges in a small mammal
Q43070521	Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues
Q35645517	Measuring the incentive value of escalating doses of heroin in heroin-dependent Fischer rats during acute spontaneous withdrawal
Q33550876	Mechanisms of endogenous pain modulation illustrated by placebo analgesia : functional imaging findings
Q33946821	Mechanisms of pain
Q36040286	Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
Q34788555	Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway
Q28564599	Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling
Q37137778	Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.
Q33989899	Methadone: a review of its pharmacokinetic/pharmacodynamic properties.
Q28510086	Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
Q33780850	Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception
Q37422108	Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity
Q30524653	Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice
Q79776267	Modification of morphine-induced hyperlocomotion and antinociception in mice by clorgyline, a monoamine oxidase-A inhibitor
Q57812851	Modulation of Opioid Transport at the Blood-Brain Barrier by Altered ATP-Binding Cassette (ABC) Transporter Expression and Activity
Q33788059	Modulation of feeding and locomotion through mu and delta opioid receptor signaling in the nucleus accumbens
Q35769311	Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12
Q34247711	Modulation of pain transmission by G-protein-coupled receptors
Q33608286	Molecular insights into mu opioid pharmacology: From the clinic to the bench
Q34922365	Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys?
Q40037212	Morphine Inhibited the Rat Neural Stem Cell Proliferation Rate by Increasing Neuro Steroid Genesis.
Q38601577	Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src
Q39146466	Morphine and fentanyl differently affect MOP and NOP gene expression in human neuroblastoma SH-SY5Y cells
Q48298294	Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent rat.
Q36100024	Morphine disrupts long-range synchrony of gamma oscillations in hippocampal slices
Q35063629	Morphine enhances Tat-induced activation in murine microglia.
Q37152999	Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis
Q98290066	Morphine in the Setting of Acute Heart Failure: Do the Risks Outweigh the Benefits?
Q35661518	Morphine induces desensitization of insulin receptor signaling
Q31804152	Morphine induces short-lived changes in G-protein gene expression in rat prefrontal cortex
Q44336809	Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.
Q44341922	Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system
Q42702299	Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion
Q36280218	Morphine-activated opioid receptors elude desensitization by beta-arrestin
Q43638936	Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits.
Q41605692	Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.
Q36984756	Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins
Q37376293	Morphine-induced nitric oxide production in isolated, iris-ciliary bodies
Q24646270	Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6
Q47366337	Morphine-induced place preference affects mRNA expression of G protein α subunits in rat brain
Q34383602	Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence
Q24674873	Morphine-stimulated nitric oxide release in rabbit aqueous humor
Q37113199	Morphine: a protective or destructive role in neurons?
Q43875647	Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.
Q35199976	Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice
Q34401595	Mouse mu opioid receptor gene expression. A 34-base pair cis-acting element inhibits transcription of the mu opioid receptor gene from the distal promoter
Q43792471	Mouse strain differences in opiate reward learning are explained by differences in anxiety, not reward or learning.
Q34795487	Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis.
Q44343229	Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food.
Q28474735	Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task
Q44353181	Mu and kappa1 opioid-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in cynomolgus monkey brain
Q34651031	Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers
Q37279348	Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner
Q38633387	Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin
Q37385680	Mu opioid receptor modulation of somatodendritic dopamine overflow: GABAergic and glutamatergic mechanisms
Q44350366	Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking
Q33581970	Mu opioid receptors in pain management
Q90034363	Mu opioid receptors in the medial habenula contribute to naloxone aversion
Q28533332	Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice
Q37236111	Mu opioids and their receptors: evolution of a concept
Q36983043	Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors
Q44341571	Mu-opioid Receptors Facilitate the Propagation of Excitatory Activity in Rat Hippocampal Area CA1 by Disinhibition of all Anatomical Layers
Q28590279	Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
Q33882631	Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays.
Q44329819	Mu-opioid receptors are involved in the tolerance to nicotine antinociception
Q35748006	Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia
Q43563172	Mu-opioid receptors are present in functionally identified sympathoexcitatory neurons in the rat rostral ventrolateral medulla
Q30367911	Music and social bonding: "self-other" merging and neurohormonal mechanisms.
Q47816071	NMDA receptor-dependent long term hyperalgesia after tail amputation in mice
Q48255291	NPYFa, A Chimeric Peptide of Met-Enkephalin, and NPFF Induces Tolerance-Free Analgesia
Q43781005	Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice
Q36762428	Naloxone treatment in opioid addiction: the risks and benefits
Q36884622	Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons
Q34616139	Neural systems underlying opiate addiction.
Q34535855	Neurobiology of addiction: a neurocircuitry analysis
Q59385181	Neuroimmune mechanisms of psychostimulant and opioid use disorders
Q35177355	Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS.
Q24658250	Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons
Q33822246	Neuropeptides and sexual behaviour
Q44880443	Neuroscience of addiction
Q41742748	New delta-opioid antagonists as pharmacological probes.
Q46243671	New directions in pain research: molecules to maladies
Q28111990	Nicotine and endogenous opioids: Neurochemical and pharmacological evidence
Q44350077	No heroin or morphine 6beta-glucuronide analgesia in mu-opioid receptor knockout mice
Q44328327	Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain
Q41098806	Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response involves protein kinase C.
Q79970098	Nociceptive and morphine antinociceptive sensitivity of 129 and C57BL/6 inbred mouse strains: implications for transgenic knock-out studies
Q24319975	Nocistatin, a peptide that blocks nociceptin action in pain transmission
Q90288944	Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect
Q36104010	Novel approaches for the treatment of psychostimulant and opioid abuse - focus on opioid receptor-based therapies
Q34106722	Novel approaches to targeting neuropeptide systems
Q30278500	Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules
Q44333029	Numerical density of delta-opioid receptor expressing neurons in the frontal cortex of drug-related fatalities
Q31555435	Numerical density of mu opioid receptor expressing neurons in the frontal cortex of drug related fatalities
Q44349876	ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing
Q43070644	Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists
Q36694953	Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections
Q38025200	Opioid genetics: the key to personalized pain control?
Q34116565	Opioid receptor and peptide gene polymorphisms: potential implications for addictions
Q44331169	Opioid receptor endocytosis and activation of MAP kinase pathway
Q39027943	Opioid receptor gene expression in human neuroblastoma SH-SY5Y cells following tapentadol exposure
Q27004306	Opioid receptor heteromers in analgesia
Q38085387	Opioid receptor interacting proteins and the control of opioid signaling.
Q34612123	Opioid receptor polymorphisms and opioid abuse
Q44342096	Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation
Q37938862	Opioid receptor trafficking and signaling: what happens after opioid receptor activation?
Q36304802	Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.
Q89207660	Opioid receptors: drivers to addiction?
Q37249017	Opioid receptors: from binding sites to visible molecules in vivo
Q41651018	Opioid receptors: pinning down the opiate targets
Q27002925	Opioid receptors: toward separation of analgesic from undesirable effects
Q34305249	Opioid rotation in clinical practice
Q37065797	Opioid tolerance development: a pharmacokinetic/pharmacodynamic perspective
Q28581321	Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase
Q34323667	Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment
Q36843509	Opioids and social bonding: naltrexone reduces feelings of social connection
Q34437456	Opioids and their receptors: Are we there yet?
Q47930841	Opioids modulate the calcitonin gene-related peptide8-37-mediated hindpaw withdrawal latency increase in thermally injured rats
Q35881855	Opioids potentiate electrical transmission at mixed synapses on the Mauthner cell
Q33547877	Opioids: first lessons from knockout mice
Q64883510	Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias.
Q36895853	Oral extended-release oxymorphone: a new choice for chronic pain relief
Q36367877	Ovarian hormones and migraine headache: understanding mechanisms and pathogenesis--part I.
Q37091369	Ovarian steroids modulate leu-enkephalin levels and target leu-enkephalinergic profiles in the female hippocampal mossy fiber pathway
Q28140910	Pain responses in methadone-maintained opioid abusers
Q39150818	Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence
Q43192342	Parallel modulation of receptor for activated C kinase 1 and protein kinase C-alpha and beta isoforms in brains of morphine-treated rats
Q42155707	Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice
Q34605733	Parvalbumin-containing fast-spiking basket cells generate the field potential oscillations induced by cholinergic receptor activation in the hippocampus.
Q33797829	Persistent pain model reveals sex difference in morphine potency
Q37201611	Pharmacogenetic treatments for drug addiction: alcohol and opiates.
Q34081709	Pharmacogenetics of alcohol and alcohol dependence treatment
Q36110592	Pharmacogenetics of analgesic drugs
Q48490118	Pharmacogenetics of opiates in clinical practice: the visible tip of the iceberg
Q34116570	Pharmacogenomics and addiction to opiates
Q37932516	Pharmacogenomics of the human µ-opioid receptor
Q44334357	Pharmacokinetic and pharmacodynamic modeling of opioid-induced gastrointestinal side effects in patients receiving tapentadol IR and oxycodone IR.
Q91598924	Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist
Q37679197	Pharmacological Profiles of Oligomerized μ-Opioid Receptors
Q38352343	Pharmacological characterization of AR-M1000390 at human delta opioid receptors
Q38300930	Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide
Q44333416	Pharmacological profiles of selective non-peptidic delta opioid receptor ligands
Q36932895	Pharmacological selectivity of CTAP in a warm water tail-withdrawal antinociception assay in rats
Q34088749	Pharmacology of amphibian opiate peptides
Q34810395	Pharmacotherapy of addictions
Q44345034	Phosphatidylinositol-3 kinase is distinctively required for mu-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinase
Q90788710	Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion
Q34016207	Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis
Q48607206	Place preference test in rodents
Q34445458	Placebo effects mediated by endogenous opioid activity on mu-opioid receptors.
Q42326079	Placebo-induced analgesia in an operant pain model in rats
Q36266246	Polydrug abuse: a review of opioid and benzodiazepine combination use
Q27027736	Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications
Q44333978	Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation.
Q44345022	Preimplantation mouse embryo is a target for opioid ligand-receptor signaling
Q44342551	Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors.
Q44352134	Promoter activity of mouse kappa opioid receptor gene in transgenic mouse
Q35658836	Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women
Q36763059	Propagation of conformational changes during μ-opioid receptor activation
Q31816606	Proteasome involvement in agonist-induced down-regulation of mu and delta opioid receptors
Q43557316	Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase).
Q31012143	Purification and mass spectrometric analysis of the μ opioid receptor
Q44347879	Quantitative autoradiographic mapping of mu-, delta- and kappa-opioid receptors in knockout mice lacking the mu-opioid receptor gene
Q28505253	Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice
Q44044472	Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains and spinal cords of mice deficient in the mu-opioid receptor gene.
Q44351559	Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice
Q36763815	Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection
Q44349148	Quantitative immunolocalization of mu opioid receptors: regulation by naltrexone
Q44340203	Quantitative single-cell differences in mu-opioid receptor mRNA distinguish myelinated and unmyelinated nociceptors.
Q39444998	Rational treatment of addiction
Q38736252	Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics
Q34418203	Recent advances in the use of opioids for cancer pain
Q34283883	Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system
Q33920823	Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice
Q38346695	Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses
Q28363073	Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction
Q34112684	Region specific up-regulation of oxytocin receptors in the opioid oprm1 (-/-) mouse model of autism
Q36358112	Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance
Q42443898	Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice.
Q44345799	Regulation of immunolabelled mu-opioid receptors and protein kinase C-alpha and zeta isoforms in the frontal cortex of human opiate addicts
Q32062002	Regulation of mouse kappa opioid receptor gene expression by retinoids.
Q34113042	Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization
Q37767447	Regulation of opioid receptors by opioid antagonists: implications for rapid opioid detoxification
Q24603928	Regulation of opioid tolerance by let-7 family microRNA targeting the mu opioid receptor
Q36591603	Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.
Q37228167	Regulator of G protein signaling proteins differentially modulate signaling of mu and delta opioid receptors
Q38420812	Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum
Q57284888	Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels
Q44331077	Relationship of mu opioid receptor binding to activation of G-proteins in specific rat brain regions
Q44351630	Relevance of frequent mu-opioid receptor polymorphisms for opioid activity in healthy volunteers
Q44348307	Repeated restraint stress reduces opioid receptor binding in different rat CNS structures
Q43612672	Respiratory function in adult mice lacking the mu-opioid receptor: role of delta-receptors
Q52534596	Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1.
Q44330314	Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
Q35786247	Reward processing by the opioid system in the brain.
Q51400644	Rewarding effects of opiates are absent in mice lacking the receptor for substance P.
Q37162162	Rewarding morphine-induced synaptic function of delta-opioid receptors on central glutamate synapses
Q50682037	Rewarding or aversive effects of buprenorphine/naloxone combination (Suboxone) depend on conditioning trial duration.
Q92825246	Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming
Q41879862	Role of different brain structures in the behavioural expression of WIN 55,212-2 withdrawal in mice.
Q41531803	Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons.
Q44350348	Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question
Q47711187	Role of the guanine nucleotide binding protein, Gαo, in the development of morphine tolerance and dependence
Q33807778	Search for the "ideal analgesic" in pain treatment by engineering the mu-opioid receptor
Q33727027	Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms
Q28378301	Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors
Q59131861	Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner
Q41009880	Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling
Q35146154	Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.
Q28583157	Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity
Q35776788	Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception
Q60678549	Sind μ-Opioidrezeptorpolymorphismen wichtig für die Opioidtherapie?
Q44333302	Single-stranded DNA-binding complex involved in transcriptional regulation of mouse mu-opioid receptor gene
Q34157204	Social influences on morphine sensitization in adolescent females.
Q34157398	Socially induced morphine pseudosensitization in adolescent mice.
Q44330721	Specific activation of the mu opioid receptor (MOR) by endomorphin 1 and endomorphin 2.
Q35205465	Spinal delivery of analgesics in experimental models of pain and analgesia
Q51145621	Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.
Q46885711	Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation
Q37083915	Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin
Q35747694	Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor
Q34073218	Structural basis for μ-opioid receptor binding and activation
Q34488374	Structural insights into µ-opioid receptor activation
Q56674183	Structure of the µ-opioid receptor–Gi protein complex
Q57159474	Structure-Activity Relationship Studies of 6α- and 6β-Indolylacetamidonaltrexamine Derivatives as Bitopic Mu Opioid Receptor Modulators and Elaboration of the "Message-Address Concept" To Comprehend Their Functional Conversion
Q47256238	Study of analgesic effect of earthworm extract
Q39457258	Study on the activation of the opioid receptors by a set of morphine derivatives in a well-defined assay system
Q30707290	Substance abuse vulnerability loci: converging genome scanning data
Q44344913	Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden
Q32027306	Suppressive effects of oxcarbazepine on tooth pulp-evoked potentials recorded at the trigeminal spinal tract nucleus in cats
Q45759119	Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine
Q36431999	Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity
Q38192648	Synaptic changes induced by melanocortin signalling.
Q33806664	Synaptic mechanism for functional synergism between delta- and mu-opioid receptors
Q44343990	Synthesis and Opioid Activity of Tyr1 -ψ[(Z)CF=CH]-Gly2 and Tyr1 -ψ[(S)/(R)-CF3 CH-NH]-Gly2 Leu-enkephalin Fluorinated Peptidomimetics
Q43832761	Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity
Q37333006	Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.
Q37186178	Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.
Q37310339	T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice
Q44350826	TH-030418: a potent long-acting opioid analgesic with low dependence liability
Q47332344	TRPV1 is a physiological regulator of μ-opioid receptors.
Q36343383	Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
Q33559498	Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
Q39221109	Targeting multiple opioid receptors - improved analgesics with reduced side effects?
Q27001692	Telomeres and epigenetics: potential relevance to chronic pain
Q39371102	Tetrapeptide Endomorphin Analogs Require Both Full Length and Truncated Splice Variants of the Mu Opioid Receptor Gene Oprm1 for Analgesia
Q35859775	The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine
Q91796599	The Cholinergic System as a Treatment Target for Opioid Use Disorder
Q92644109	The Emerging Perspective of Morphine Tolerance: MicroRNAs
Q91813555	The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats
Q49077685	The NK1 receptor is essential for the full expression of noxious inhibitory controls in the mouse
Q90107822	The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models
Q35184664	The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
Q55315782	The Regulatory Mechanisms and Therapeutic Potential of MicroRNAs: From Chronic Pain to Morphine Tolerance.
Q35974778	The antiallodynic action of pregabalin in neuropathic pain is independent from the opioid system
Q33455500	The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction
Q42170936	The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain
Q38164427	The challenges of LC-MS/MS analysis of opiates and opioids in urine
Q44345198	The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice
Q93542143	The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues
Q34578586	The diverse molecular mechanisms responsible for the actions of opioids on the cardiovascular system
Q57137163	The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes
Q34965644	The effects of analgesia in the vulnerable infant during the perinatal period.
Q33779667	The effects of opioids and opioid analogs on animal and human endocrine systems
Q42325921	The endogenous opioid system and drug addiction
Q36110480	The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us?
Q44339249	The full-length mu-opioid receptor: a conformational study by circular dichroism in trifluoroethanol and membrane-mimetic environments
Q33679576	The genetic mediation of individual differences in sensitivity to pain and its inhibition
Q34431107	The genetics of addictions: uncovering the genes
Q34991740	The heritability of oxycodone reward and concomitant phenotypes in a LG/J × SM/J mouse advanced intercross line
Q51402683	The human nucleus accumbens is highly susceptible to G protein down-regulation by methamphetamine and heroin.
Q41872053	The kappa opioid receptor is associated with the perception of visceral pain
Q34185953	The molecular dynamics of pain control
Q33679584	The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses
Q42126097	The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference
Q44329891	The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice
Q44345741	The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia
Q52628758	The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception.
Q43637785	The opioid placebo analgesia is mediated exclusively through μ-opioid receptor in rat.
Q89464718	The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
Q34333349	The pharmacology of mu analgesics: from patients to genes
Q44336740	The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses
Q36007926	The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice
Q44346086	The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors
Q34311504	The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
Q37753286	The role of functional postsynaptic NMDA receptors in the central nucleus of the amygdala in opioid dependence
Q35871222	The role of mu opioid receptors in psychomotor stimulation and conditioned place preference induced by morphine-6-glucuronide
Q44334078	The role of opioid receptors in morphine withdrawal in the infant rat.
Q34268488	The role of the brain reward system in depression
Q55038697	The state of GPCR research in 2004.
Q31840219	The untranslated region of (mu)-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice.
Q36389121	Tolerance and sensitization to chronic escalating dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors
Q33604982	Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence
Q64110165	TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice
Q44350146	Transcriptional regulation of mouse mu-opioid receptor gene
Q39391430	Transdermal buprenorphine for treatment of chronic tumor and non-tumor pain
Q34235012	Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
Q36770675	Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS.
Q40277139	Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats
Q41353570	Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method
Q24634901	Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
Q48094995	Unique behavioural phenotypes of recombinant-inbred CXBK mice: partial deficiency of sensitivity to mu- and kappa-agonists
Q30499644	Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
Q34028220	Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells
Q36403790	Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward
Q46973639	Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Q73170015	Use of selective antagonists and antisense oligonucleotides to evaluate the mechanisms of BUBU antinociception
Q43075530	Usefulness of knockout mice to clarify the role of the opioid system in chronic pain.
Q51990334	Using knockout and transgenic mice to study neurophysiology and behavior.
Q91474276	Variation in the μ-opioid receptor gene (OPRM1) and experiences of felt security in response to a romantic partner's quarrelsome behavior
Q44351535	Visceral chemical nociception in mice lacking mu-opioid receptors: effects of morphine, SNC80 and U-50,488.
Q78245433	What's all the RAVE about receptor internalization?
Q64119307	Why Do Birds Flock? A Role for Opioids in the Reinforcement of Gregarious Social Interactions
Q82032260	Why does morphine make you itch?
Q57466905	Why mu-opioid agonists have less analgesic efficacy in neuropathic pain?
Q46463949	Withdrawal symptom after discontinuation of transdermal fentanyl at a daily dose of 0.6 mg.
Q33893116	Withdrawal syndromes
Q89638441	Wrist-ankle acupuncture attenuates cancer-induced bone pain by regulating descending pain-modulating system in a rat model
Q73213332	[Mechanisms of opioid tolerance and opioid dependence]
Q72990194	[Understanding of molecular biology]
Q44330291	delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice
Q37476172	miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats
Q36014007	micro-Opioid receptor activation prevents acute hepatic inflammation and cell death
Q44348420	mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality
Q43670362	mu Opioid receptor-mediated G-protein activation by heroin metabolites: evidence for greater efficacy of 6-monoacetylmorphine compared with morphine
Q40893577	mu Opioid receptor: role for the amino terminus as a determinant of ligand binding affinity
Q41012113	mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control
Q44348820	mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit
Q28270615	mu-Opposing actions of the kappa-opioid receptor
Q44338719	mu-opioid receptor-mediated antinociceptive responses differ in men and women.
Q38167644	β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia
Q35039212	κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain
Q37093727	μ- and δ-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice
Q38285112	μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids
Q34939720	μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons
Q90713662	μ-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia
Q36927128	μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche
Q38355088	μ-opioid modulation of HIV-1 coreceptor expressionand HIV-1 replication

P6179	Dimensions Publication ID	1008426943
P356	DOI	10.1038/383819A0
P698	PubMed publication ID	8893006

P2093	author name string	J Hanoune
		B P Roques
		R Maldonado
		A Dierich
		B L Kieffer
		H W Matthes
		K Befort
		I Kitchen
		O Valverde
		P Dollé
		E Tzavara
		F Simonin
		M Le Meur
		S Slowe
P2860	cites work	A brief history of opiates, opioid peptides, and opioid receptors	Q24562762
		The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization	Q30800519
		The mouse Pgk-1 gene promoter contains an upstream activator sequence	Q35788889
		Neurobiology of opiate abuse	Q36208827
		Mechanisms of the analgesic actions of opiates and opioids	Q36465590
		delta-Opioid receptor subtypes and cross-talk with mu-receptors	Q40853754
		Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides	Q41041826
		Precipitation of morphine withdrawal syndrome in rats by administration of mu-, delta- and kappa-selective opioid antagonists	Q44332157
		Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides	Q44342386
		A mu-opioid receptor-filter assay. Rapid estimation of binding affinity of ligands and reversibility of long-lasting ligand-receptor complexes	Q44343425
		Opioid peptides have found their roots	Q44352136
		Motivational properties of opioids: evidence that an activation of delta-receptors mediates reinforcement processes	Q48171483
		Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression	Q48654359
		A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function	Q48722567
		Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.	Q48944677
		The CCKB antagonist PD-134,308 facilitates rewarding effects of endogenous enkephalins but does not induce place preference in rats.	Q52203788
		A rapid and inexpensive technique for assessing the reinforcing effects of opiate drugs	Q52301792
		Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.	Q54572810
P433	issue	6603
P407	language of work or name	English	Q1860
P921	main subject	opioid	Q427523
P1104	number of pages	5
P304	page(s)	819-823
P577	publication date	1996-10-01
P1433	published in	Nature	Q180445
P1476	title	Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene
P478	volume	383

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

scientific article published on October 1996

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