The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses

scientific article

The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/AAS.12739
P698PubMed publication ID27113810

P50authorStein KaasaQ12002891
Frank SkorpenQ42754223
Pål KlepstadQ38136464
Ola DaleQ38136651
P2093author name stringA H Skogholt
M Bjørngaard
S von Hofacker
P2860cites workIntravenous opioid dosing and outcomes in emergency patients: a prospective cohort analysisQ42913619
Ethnicity influences morphine pharmacokinetics and pharmacodynamicsQ43775267
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of painQ44341121
The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant diseaseQ44347117
mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethalityQ44348420
Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patientsQ44349850
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patientsQ46520044
Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS studyQ47919321
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitizationQ28276743
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesiaQ28585437
The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncologyQ29615701
A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signalingQ31532158
COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressorQ33964426
Opioid rotation for toxicity reduction in terminal cancer patientsQ34305300
Opioids and their receptors: Are we there yet?Q34437456
The N-terminally truncated µ3 and µ3-like opioid receptors are transcribed from a novel promoter upstream of exon 2 in the human OPRM1 geneQ34948489
Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectivesQ35941387
Pain sensitivity and opioid analgesia: a pharmacogenomic twin studyQ36040669
Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving OpioidsQ36751995
Functional characterization of human variants of the mu-opioid receptor geneQ37249905
Establishing "best practices" for opioid rotation: conclusions of an expert panelQ37593253
µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for painQ38162871
A Systematic Review of Prospective Studies Reporting Adverse Events of Commonly Used Opioids for Cancer-Related Pain: A Call for the Use of Standardized Outcome Measures.Q38519237
Assessing the response to opioids in cancer patients: a methodological proposal and the resultsQ39197627
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor geneQ41157124
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectopioidQ427523
P304page(s)1084-1091
P577publication date2016-04-26
P1433published inActa Anaesthesiologica ScandinavicaQ59829
P1476titleThe rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses
P478volume60

Reverse relations

Q56674183Structure of the µ-opioid receptor–Gi protein complexcites workP2860

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