Pharmacogenomics of the human µ-opioid receptor

scientific article published on September 2011

Pharmacogenomics of the human µ-opioid receptor is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.2217/PGS.11.68
P698PubMed publication ID21919606

P2093author name stringKazutaka Ikeda
Shinya Kasai
P2860cites workHuman mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignmentQ24318653
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addictionQ24320057
Genetic susceptibility to heroin addiction: a candidate gene association studyQ24634090
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) studyQ24645469
Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, OprmQ28250678
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesiaQ28585437
Drug abuse: hedonic homeostatic dysregulationQ29615904
Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokersQ30486679
The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cellsQ30821241
A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signalingQ31532158
Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic miceQ33263445
Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American IndiansQ33330500
Expansion of the human mu-opioid receptor gene architecture: novel functional variantsQ33395205
The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americansQ33598156
The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responsesQ33679584
Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypesQ33797971
Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorderQ33913645
Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differencesQ44706338
Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators.Q45971153
Relatively strong automatic appetitive action-tendencies in male carriers of the OPRM1 G-allele.Q46240029
Clinical response to morphine in cancer patients and genetic variation in candidate genesQ46653217
Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease.Q46910776
Unique behavioural phenotypes of recombinant-inbred CXBK mice: partial deficiency of sensitivity to mu- and kappa-agonistsQ48094995
Family history of alcoholism and hypothalamic opioidergic activityQ48323999
Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotypeQ48463805
Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence.Q50888473
Association of the functional A118G polymorphism of OPRM1 in diabetic patients with foot ulcer pain.Q51756681
Genetic moderators of naltrexone's effects on alcohol cue reactivity.Q51791744
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.Q51955912
Association of OPRM1 A118G variant with the relative reinforcing value of nicotine.Q52007326
Environmental and genetic factors associated with morphine response in the postoperative periodQ57611840
Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkersQ34180425
A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers.Q34573827
Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sampleQ34614468
Exploring the opioid system by gene knockoutQ34641459
Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusersQ34651031
Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled studyQ34674680
A clinical genetic method to identify mechanisms by which pain causes depression and anxiety.Q34715898
Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor geneQ34902609
The mu-opioid receptor gene and smoking initiation and nicotine dependenceQ35012142
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependenceQ35189955
Genomic structure analysis of promoter sequence of a mouse mu opioid receptor geneQ35762035
What place does naltrexone have in the treatment of alcoholism?Q35820303
Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT geneQ36016764
Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysisQ36050631
How individual sensitivity to opiates can be predicted by gene analysesQ36145129
mu opiate receptor: cDNA cloning and expressionQ36641338
Nicotine abstinence-induced cerebral blood flow changes by genotypeQ36776193
Association of candidate genes with antisocial drug dependence in adolescentsQ36952343
Initial evidence of an association between OPRM1 and adolescent alcohol misuseQ36952699
The mu opioid receptor A118G gene polymorphism moderates effects of trait anger-out on acute pain sensitivityQ37037939
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actionsQ37140009
Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring womenQ37158552
OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approachQ37185125
Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behaviorQ37250051
Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative painQ37259162
Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative moodQ37280300
Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making networkQ37311980
Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejectionQ37329591
Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environmentQ37344738
Naltrexone alone and with sertraline for the treatment of alcohol dependence in Alaska natives and non-natives residing in rural settings: a randomized controlled trialQ37351522
Do genetic predictors of pain sensitivity associate with persistent widespread pain?Q37382439
Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatmentQ37580433
Cloning and pharmacological characterization of a rat mu opioid receptorQ38314662
Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.Q39329852
Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activationQ44336855
A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian originQ44337414
A functional polymorphism of the micro-opioid receptor gene is associated with completed suicidesQ44337737
Effects of fentanyl on gastric myoelectrical activity: a possible association with polymorphisms of the mu-opioid receptor gene?Q44338482
Association between mu-opioid receptor-1 102T>C polymorphism and intermediate type 2 diabetes phenotypes: results from the Quebec Family Study (QFS).Q44338984
Lack of association of a single-nucleotide polymorphism of the mu-opioid receptor gene with anxiety-related traits: results from a cross-sectional study of adults and a longitudinal study of children.Q44339302
RETRACTED: Association of mu-opioid receptor subunit gene and idiopathic generalized epilepsyQ44339329
Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatmentQ44339701
A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesiaQ44339910
A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patientsQ44340139
Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.Q44340286
Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the mu opioid receptor gene in 10 inbred mouse strainsQ44340414
Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).Q44340730
Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.Q44340770
Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependenceQ44340859
Mu opioid receptor gene polymorphisms and heroin dependence in Asian populationsQ44340982
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of painQ44341121
A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patientsQ44341917
Association of polymorphism in the human mu-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perceptionQ44342193
Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addictionQ44342438
A genetic association study of the mu opioid receptor and severe opioid dependenceQ44342768
Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic studyQ44343433
Mu opioid receptor gene polymorphism and neuroleptic-induced tardive dyskinesia in patients with schizophreniaQ44343563
Loss of nicotine-induced behavioral sensitization in micro-opioid receptor knockout miceQ44343994
Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han.Q44344319
mu-Opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion.Q44344541
The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trialQ44344781
Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central SwedenQ44344913
Mu opioid receptor gene as a candidate for the study of obsessive compulsive disorder with and without ticsQ44345313
Association study of personality factors and the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1).Q44345618
Association of functional opioid receptor genotypes with alcohol dependence in KoreansQ44346071
The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant diseaseQ44347117
Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central SwedenQ44347200
Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependenceQ44347354
Mu opioid receptor gene variants: lack of association with alcohol dependenceQ44347504
A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humansQ44347594
Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response.Q44348189
The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humansQ44348360
mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethalityQ44348420
Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patientsQ44349048
Characterization of the 3' untranslated region of the human mu-opioid receptor (MOR-1) mRNA.Q44350206
Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American populationQ44350314
The porcine mu opioid receptor: molecular cloning and mRNA distribution in lymphoid tissuesQ44350566
Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysisQ44351470
Anger regulation style, postoperative pain, and relationship to the A118G mu opioid receptor gene polymorphism: a preliminary studyQ44351528
Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms.Q44351548
Relevance of frequent mu-opioid receptor polymorphisms for opioid activity in healthy volunteersQ44351630
mu-opioid receptor variants and dopaminergic sensitivity in alcohol withdrawalQ44352311
Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjectsQ44352947
Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine TherapyQ44403651
Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese populationQ39342490
Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomyQ39348026
Association of the mu-opioid receptor gene with smoking cessationQ40251616
Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.Q40392922
Immunohistochemical study of the expression of exon11-containing mu opioid receptor variants in mouse brainQ40533852
Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptorQ40566502
Adrenocorticotropin responses to naloxone in sons of alcohol-dependent men.Q40827257
Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependenceQ40913413
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor geneQ41157124
Cocaine, dopamine and the endogenous opioid systemQ41243604
The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preferenceQ42126097
Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trialQ42636195
Observational study of the effect of mu-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia.Q43155752
Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patientsQ43225221
Polymorphism of the micro-opioid receptor gene (OPRM1 118A>G) affects fentanyl-induced analgesia during anesthesia and recoveryQ43269189
Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgeryQ43270791
Ethanol consumption and reward are decreased in mu-opiate receptor knockout miceQ43567780
Genetic analysis of the mu-opioid receptor in alcohol-dependent individualsQ43719684
Predicting treatment response to naltrexone: the influence of craving and family historyQ43752726
The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockadeQ43829059
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphineQ43843765
A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substancesQ43882794
Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient miceQ43937577
Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroinQ43947676
Adrenocorticotropin and cortisol responses to a naloxone challenge and risk of alcoholismQ43960583
Hypothalamic-pituitary-adrenocortical (HPA) axis response and biotransformation of oral naltrexone: preliminary examination of relationship to family history of alcoholismQ43991017
OPRM1 gene is associated with BMI in Uyghur populationQ44035784
Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice.Q44050781
Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?Q44161387
Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice.Q44282777
Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteersQ44289543
Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese populationQ44330319
Intracisternal A-particle element in the 3' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivityQ44330465
Genetic variation of the human mu-opioid receptor and susceptibility to idiopathic absence epilepsyQ44330504
Immunohistochemical labeling of the mu opioid receptor carboxy terminal splice variant mMOR-1B4 in the mouse central nervous systemQ44331040
Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplastyQ44331545
The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriersQ44331665
A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic painQ44332189
No association of single nucleotide polymorphisms in the micro-opioid receptor subunit gene with idiopathic generalized epilepsyQ44332505
The Asp40 mu-opioid receptor allele does not predict naltrexone treatment efficacy in heavy drinkersQ44333481
The opioid system in alcohol and drug dependence: family-based association studyQ44335036
Association between mu opioid receptor gene polymorphisms and Chinese heroin addictsQ44335420
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptorsQ44336603
Polymorphisms of mu and delta opioid receptor genes and tardive dyskinesia in patients with schizophreniaQ44336701
P433issue9
P921main subjectopioidQ427523
pharmacogenomicsQ1152227
P304page(s)1305-1320
P577publication date2011-09-01
P1433published inPharmacogenomicsQ15724625
P1476titlePharmacogenomics of the human µ-opioid receptor
P478volume12

Reverse relations

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