Desensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector

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Desensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2002PNAS...99.4674B
P356DOI10.1073/PNAS.072075399
P932PMC publication ID123706
P698PubMed publication ID11917119
P5875ResearchGate publication ID11447769

P2093author name stringChristophe Blanchet
Christian Lüscher
P2860cites workEvolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signalingQ30014843
Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunitsQ30305956
Single potassium channels opened by opioids in rat locus ceruleus neuronsQ33855070
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.Q33873664
Molecular mechanisms and regulation of opioid receptor signalingQ33932163
Downregulation of G protein-coupled receptorsQ33941580
Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawalQ34104454
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.Q34336625
Opposing mechanisms of regulation of a G-protein-coupled inward rectifier K+ channel in rat brain neuronsQ34634968
Characterization of acute homologous desensitization of mu-opioid receptor-induced currents in locus coeruleus neurones.Q35872868
Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channelsQ36319780
Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slicesQ38179532
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cellsQ39399994
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.Q41080173
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor geneQ41157124
Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activationQ42065529
Inhibition of a Gi-activated potassium channel (GIRK1/4) by the Gq-coupled m1 muscarinic acetylcholine receptorQ42495425
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GbetagammaQ42544747
Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneuronsQ44333178
Transient homologous mu-opioid receptor desensitization in rat locus coeruleus neuronsQ44334111
Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitroQ44339520
Cellular mechanisms of opioid tolerance: studies in single brain neuronsQ44342163
Opioid desensitization: interactions with G-protein-coupled receptors in the locus coeruleusQ44342614
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunitsQ46072516
G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neuronsQ46524326
Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: interactions among multiple receptors.Q48380239
Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampusQ48415532
How opioids inhibit GABA-mediated neurotransmissionQ48580369
Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitizationQ48886242
Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats.Q51747896
Functional coupling between neurons and glia.Q52539296
Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitroQ60727971
Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neuronsQ69926021
Presynaptic receptorsQ74578161
G protein-coupled receptor kinasesQ77366588
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectdesensitizationQ2700499
opioidQ427523
P304page(s)4674-4679
P577publication date2002-03-26
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDesensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector
P478volume99

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