NPYFa, A Chimeric Peptide of Met-Enkephalin, and NPFF Induces Tolerance-Free Analgesia

scientific article published on 23 January 2016

NPYFa, A Chimeric Peptide of Met-Enkephalin, and NPFF Induces Tolerance-Free Analgesia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CBDD.12721
P8608Fatcat IDrelease_df3y3vun2fhm3c6spcf7fpthzu
P698PubMed publication ID26802437

P50authorCatherine MollereauQ59784775
Santosh PashaQ96206628
P2093author name stringKrishan Kumar
Annu Mudgal
P2860cites workDynorphin-(1-13), an extraordinarily potent opioid peptideQ24561638
Receptor heteromerization and drug discoveryQ24631740
G-protein-coupled receptor heteromers: function and ligand pharmacologyQ24653717
Modulatory role of neuropeptide FF system in nociception and opiate analgesiaQ28248571
Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activityQ28283440
Modulatory roles of the NPFF system in pain mechanisms at the spinal levelQ28294362
Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cellsQ28299030
Neuropeptide FF and modulation of painQ33804790
Opioid-receptor-heteromer-specific trafficking and pharmacologyQ33978499
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesiaQ34249621
GPCR heteromers and their allosteric receptor-receptor interactionsQ34254454
Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activityQ34354902
Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1.Q34559158
In vivo opioid receptor heteromerization: where do we stand?Q34939677
Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profileQ34983352
A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networksQ35123224
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in miceQ35218957
A review of the role of anti-opioid peptides in morphine tolerance and dependenceQ35275948
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.Q35708164
Opioid-modulating peptides: mechanisms of actionQ36109084
Peptide-membrane interactions and a new principle in quantitative structure-activity relationshipsQ36435277
Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphineQ37555862
Inhibition of spontaneous and opiate-modified nociception by an endogenous neuropeptide with Phe-Met-Arg-Phe-NH2-like immunoreactivityQ37562642
Rational design of dualsteric GPCR ligands: quests and promiseQ37688232
Opioid-modulating properties of the neuropeptide FF systemQ37783966
Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional ReceptorsQ38202835
The action of FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides on mammalsQ39561814
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor geneQ41157124
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analoguesQ42132164
Characterization of rat spinal cord receptors to FLFQPQRFamide, a mammalian morphine modulating peptide: a binding study.Q42189140
(-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulationQ44106436
Regional distribution of methionine-enkephalin-Arg6-Phe7 in the rat brain: comparative study with the distribution of other opioid peptidesQ44331210
Comparative modeling of human kappa opioid receptor and docking analysis with the peptide YFa.Q44332093
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.Q44332311
From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probesQ44335899
Low affinity of FMRFamide and four FaRPs (FMRFamide-related peptides), including the mammalian-derived FaRPs F-8-Famide (NPFF) and A-18-Famide, for opioid mu, delta, kappa 1, kappa 2a, or kappa 2b receptorsQ44336906
YFa, a chimeric opioid peptide, induces kappa-specific antinociception with no tolerance development during 6 days of chronic treatmentQ44337451
Downregulation of mu-opioid binding sites following chronic administration of neuropeptide FF (NPFF) and morphineQ44342198
Met5-enkephalin-Arg6-Phe7, an endogenous neuropeptide, binds to multiple opioid and nonopioid sites in rat brainQ44345811
Met-enkephalin-Arg6-Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonistQ44352776
FMRF-NH2-like mammalian peptide precipitates opiate-withdrawal syndrome in the rat.Q45068435
Assessing activation of the human neuropeptide FF2 receptor with a non-radioactive GTP binding assayQ45168556
Conformational analysis of dynorphin A (1-13) using hydrogen-deuterium exchange and tandem mass spectrometryQ46640668
FMRF-NH2-like mammalian octapeptide: possible role in opiate dependence and abstinenceQ48903032
Basic concepts in G-protein-coupled receptor homo- and heterodimerization.Q55136877
P433issue6
P921main subjectenkephalinQ325101
P304page(s)885-894
P577publication date2016-01-23
P1433published inChemical Biology and Drug DesignQ15749458
P1476titleNPYFa, A Chimeric Peptide of Met-Enkephalin, and NPFF Induces Tolerance-Free Analgesia
P478volume87

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