Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers.

scientific article published on 23 July 2012

Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1535-7163.MCT-11-0873
P932PMC publication ID3928542
P698PubMed publication ID22826467

P50authorLaura A MarlowQ56600296
P2093author name stringEdith A Perez
John A Copland
Simon J Cooper
Han W Tun
Gerardo Colon-Otero
Stefan K Grebe
Christina A von Roemeling
Michael E Menefee
Kylie H Kang
P2860cites workAutocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivationQ21195230
Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancerQ21245721
SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathwayQ24303537
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaQ24336272
Wnt signal transduction pathwaysQ24641814
Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growthQ24651313
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signallingQ28141530
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinomaQ28240852
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancerQ28251800
Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancerQ28260824
Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancerQ28291617
Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosisQ28294866
Gene silencing in cancer in association with promoter hypermethylationQ29617274
Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasmsQ33341474
Inhibitors of histone deacetylase as new anticancer agentsQ34372944
The changing natural history of renal cell carcinomaQ34391104
Detailed Molecular Fingerprinting of Four New Anaplastic Thyroid Carcinoma Cell Lines and Their Use for Verification of RhoB as a Molecular Therapeutic TargetQ34395370
Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylationQ34542069
Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosisQ34763742
5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapyQ34770609
Signaling pathways in renal cell carcinomaQ34978827
Triple negative breast cancer: unmet medical needsQ35630269
Novel treatments for metastatic renal cell carcinomaQ36175671
Wnt signaling through canonical and non-canonical pathways: recent progressQ36194509
FK228 (depsipeptide): a HDAC inhibitor with pleiotropic antitumor activitiesQ36376849
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancerQ36510089
Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cellsQ36759572
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and diseaseQ37102953
WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growthQ37277156
Treatment of triple-negative metastatic breast cancer: toward individualized targeted treatments or chemosensitization?Q37799942
Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinomaQ38345995
Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogsQ39564485
Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancerQ39722426
Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinomaQ39739609
Methylation-associated silencing of SFRP1 in renal cell carcinoma.Q39925650
Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma modelsQ39970361
DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell linesQ39992913
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.Q40054309
Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1.Q40343222
Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers.Q40506716
5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.Q40599594
Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell linesQ41072124
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cellsQ41446518
Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomasQ42519640
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.Q43540230
Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA.Q46696080
Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma.Q53335862
Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.Q53606125
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomasQ69018368
P4510describes a project that usesKIJ265TQ54899922
P433issue10
P921main subjectcell lineQ21014462
P304page(s)2105-2115
P577publication date2012-07-23
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleReexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers
P478volume11

Reverse relations

cites work (P2860)
Q49163340Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy
Q59353428Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells
Q35000789Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer
Q59791142Development of Fangjiomics for Systems Elucidation of Synergistic Mechanism Underlying Combination Therapy
Q34273997Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells
Q38233472Epigenetic reprogramming in breast cancer: from new targets to new therapies
Q38121995Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases.
Q89781850Epigenetics of SFRP1: The Dual Roles in Human Cancers
Q41574276Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma
Q36200052Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer
Q38979602Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration.
Q36896100Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells
Q64069266MiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway
Q47994522MicroRNA-27a Promotes the Proliferation and Invasiveness of Colon Cancer Cells by Targeting SFRP1 through the Wnt/β-Catenin Signaling Pathway
Q92287784Prognostic Relevance of SFRP1 Gene Promoter Methylation in Colorectal Carcinoma
Q28277902SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer
Q28115695Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling
Q37728993Secreted frizzled related protein 1 modulates taxane resistance of human lung adenocarcinoma
Q48091254Secreted frizzled-related protein 1 (SFRP1) gene methylation changes in the human lung adenocarcinoma cells treated with L-securinine
Q36818377Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
Q35204798Study of SFRP1 and SFRP2 methylation status in patients with de novo Acute Myeloblastic Leukemia
Q36634661Tear levels of SFRP1 are significantly reduced in keratoconus patients
Q30978083The Discovery of Novel Biomarkers Improves Breast Cancer Intrinsic Subtype Prediction and Reconciles the Labels in the METABRIC Data Set.
Q33768390The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1.
Q37061554The future of epigenetic therapy in solid tumours--lessons from the past.
Q48136812Therapeutic effects of histone deacetylase inhibitors on kidney disease.
Q37484160Tumor-specific hypermethylation of epigenetic biomarkers, including SFRP1, predicts for poorer survival in patients from the TCGA Kidney Renal Clear Cell Carcinoma (KIRC) project
Q54408874Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis.
Q47818549WNT signalling in prostate cancer.
Q49087470Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation
Q47152122miR-105/93-3p promotes chemoresistance and circulating miR-105/93-3p acts as a diagnostic biomarker for triple negative breast cancer

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