BAFF: a local and systemic target in autoimmune diseases

scientific article published on 30 July 2009

BAFF: a local and systemic target in autoimmune diseases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2249.2009.04007.X
P932PMC publication ID2768805
P698PubMed publication ID19737141
P5875ResearchGate publication ID26796024

P50authorAnne DavidsonQ38330484
P2093author name stringI Moisini
P2860cites workTACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune diseaseQ22254041
Impaired IgA class switching in APRIL-deficient miceQ24313032
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphomaQ24646563
The role of APRIL and BAFF in lymphocyte activationQ28249768
BAFF, APRIL and their receptors: structure, function and signalingQ28258238
BAFF, APRIL and human B cell disordersQ28258436
Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody productionQ28259860
BCMA is essential for the survival of long-lived bone marrow plasma cellsQ28587037
Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient miceQ28587370
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cellsQ28590517
Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritisQ30484091
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.Q30491651
Prevention of murine antiphospholipid syndrome by BAFF blockadeQ33380975
Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosusQ33928629
Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases.Q33951524
BLyS and APRIL in rheumatoid arthritisQ34084521
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndromeQ34108411
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptorQ34178508
Similarities and differences between selective and nonselective BAFF blockade in murine SLEQ34350295
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndromeQ34479625
B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndromeQ34896699
BAFF AND APRIL: a tutorial on B cell survivalQ34994661
Autoimmune disease complicating antiviral therapy for hepatitis C virus infectionQ35045126
Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic miceQ35110335
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.Q35140484
Peripheral B-cell maturation: the intersection of selection and homeostasisQ35666676
Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF productionQ35953204
BAFF and MyD88 signals promote a lupuslike disease independent of T cellsQ36229560
Splenic T zone development is B cell dependentQ36369671
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survivalQ36384731
An APRIL to remember: novel TNF ligands as therapeutic targetsQ36394955
Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.Q36402668
Identification of proteoglycans as the APRIL-specific binding partners.Q36403611
Updates from B Cell Trials: Efficacy.Q36465505
Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritisQ36537018
The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunityQ36622367
A genetic lesion that arrests plasma cell homing to the bone marrowQ36689920
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosaQ36749700
Cytokine-producing B lymphocytes-key regulators of immunityQ36775913
B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signalingQ36791432
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunityQ36811126
Activated renal macrophages are markers of disease onset and disease remission in lupus nephritisQ36985612
Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosusQ36993242
B lymphocyte stimulator regulates adaptive immune responses by directly promoting dendritic cell maturationQ37009908
TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological propertiesQ37178196
BAFF blockade for systemic lupus erythematosus: will the promise be fulfilled?Q37211258
B cells as therapeutic targets in autoimmune neurological disordersQ37278022
Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.Q37347235
A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosusQ37378350
Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus.Q39844668
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablastsQ40066472
Anti-double stranded DNA and lupus syndrome induced by interferon-beta therapy in a patient with multiple sclerosis.Q40402453
Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines.Q40474288
Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cellsQ41698462
Selective activation of TACI by syndecan-2Q42193929
The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndromeQ43050637
Concentrations of BAFF correlate with autoantibody levels, clinical disease activity, and response to treatment in early rheumatoid arthritis.Q43868814
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.Q44223059
A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responsesQ45302161
B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations.Q46001110
Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trialQ46353641
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like diseaseQ46495884
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.Q47365613
Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI.Q47368403
Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjögren's syndromeQ47739038
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature.Q51833354
Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.Q51966554
Expression of BAFF and BAFF-R in the synovial tissue of patients with rheumatoid arthritis.Q53519864
Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion.Q53547907
B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.Q54707196
Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosusQ56903374
BAFF and LPS cooperate to induce B cells to become susceptible to CD95/Fas-mediated cell deathQ56964164
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent PathwayQ57230082
Mechanism of Action of Transmembrane Activator and Calcium Modulator Ligand Interactor-Ig in Murine Systemic Lupus ErythematosusQ59031797
Attenuated apoptosis of B cell activating factor-expressing cells in primary Sjögren's syndromeQ73155009
A role for BLyS in tissue inflammation?Q73249032
Regulation of the T-independent humoral response by TACIQ73923479
Lymphoid neogenesis in rheumatoid synovitisQ74147962
Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivityQ74433998
Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cellsQ74460576
Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytesQ77488392
TACI regulates IgA production by APRIL in collaboration with HSPGQ79374551
IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cellsQ79803345
Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren's syndromeQ80060016
Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritisQ80340621
BAFF overexpression is associated with autoantibody production in autoimmune diseasesQ80367249
Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose studyQ80419633
TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cellsQ80427855
Autoantibody synthesis in primary progressive multiple sclerosis patients treated with interferon beta-1bQ81258368
Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunityQ81261843
BAFF synthesis by rheumatoid synoviocytes is positively controlled by alpha5beta1 integrin stimulation and is negatively regulated by tumor necrosis factor alpha and Toll-like receptor ligandsQ81377143
IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c miceQ81434854
Drug-induced systemic lupus erythematosus and TNF-alpha blockersQ94077789
Rituximab in relapsing-remitting multiple sclerosisQ94701888
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)155-163
P577publication date2009-07-30
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleBAFF: a local and systemic target in autoimmune diseases
P478volume158

Reverse relations

cites work (P2860)
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Q41862447Antibodies against human BLyS and APRIL attenuate EAE development in marmoset monkeys.
Q44295692Association analysis of BANK1 gene with psoriasis in Southern Han Chinese
Q38708467Autoantibodies against BAFF, APRIL or IL21 - an alternative pathogenesis for antibody-deficiencies?
Q38961202B Cell-Activating Factor (BAFF)-Targeted B Cell Therapies in Inflammatory Bowel Diseases.
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Q38932311B cells in chronic obstructive pulmonary disease: moving to center stage.
Q38026784B-cell depletion in the treatment of lupus nephritis
Q35821274B-cell-activating factor affects the occurrence of thyroid autoimmunity in chronic hepatitis C patients treated with interferon alpha
Q37495356BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells.
Q59304350BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells
Q84074798BAFF serum levels in myasthenia gravis: effects of therapy
Q36372629BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells
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Q35134860Characterization of B cells in muscle-specific kinase antibody myasthenia gravis
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Q36658257Early BAFF receptor blockade mitigates murine Sjögren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction
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