| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/S00424-009-0727-2 |
| P8608 | Fatcat ID | release_osl6djdle5hr5ojcqmghikoroa |
| P698 | PubMed publication ID | 19756718 |
| P5875 | ResearchGate publication ID | 26814518 |
| P50 | author | Giovanni G. Camici | Q55483552 |
| Yi Shi | Q59697500 | ||
| Thomas Lüscher | Q62560161 | ||
| P2860 | cites work | Negative control of p53 by Sir2alpha promotes cell survival under stress | Q24291828 |
| hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase | Q24291829 | ||
| Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase | Q24293656 | ||
| Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation | Q24293737 | ||
| Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase | Q24297207 | ||
| Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase | Q24310456 | ||
| Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats | Q46794521 | ||
| Exercise training promotes SIRT1 activity in aged rats. | Q46857793 | ||
| Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis | Q46897070 | ||
| One-year clinical outcomes of Chinese sirolimus-eluting stent in the treatment of unselected patients with coronary artery disease | Q46924913 | ||
| Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial | Q47820231 | ||
| Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. | Q50773985 | ||
| Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. | Q51565792 | ||
| Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling. | Q52573945 | ||
| Response of blood platelets to resveratrol. | Q53344628 | ||
| Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. | Q53542852 | ||
| High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients | Q58863669 | ||
| Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis | Q63365783 | ||
| Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide | Q68255434 | ||
| Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide | Q70168117 | ||
| The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro | Q70493623 | ||
| Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta | Q71482551 | ||
| Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus | Q71571202 | ||
| Megakaryocytes from patients with coronary atherosclerosis express the inducible nitric oxide synthase | Q71693112 | ||
| An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium | Q72068963 | ||
| Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase | Q72884186 | ||
| Role of matrix metalloproteinase-2 in thrombin-induced vasorelaxation of rat mesenteric arteries | Q73698476 | ||
| Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels | Q73965716 | ||
| Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues | Q74248716 | ||
| Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo | Q74561887 | ||
| Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages | Q74598485 | ||
| Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice | Q77231603 | ||
| Increased activity of H2O2 in aorta isolated from chronically streptozotocin-diabetic rats: effects of antioxidant enzymes and enzymes inhibitors | Q78115593 | ||
| Modulation of dilator responses of cerebral arterioles by extracellular superoxide dismutase | Q79157022 | ||
| The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial | Q79401451 | ||
| Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart | Q79844029 | ||
| Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes | Q80357982 | ||
| NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat | Q80392824 | ||
| Effects of chronic insulin on endothelial dysfunction of basilar arteries from established streptozotocin-diabetic rats | Q80912774 | ||
| Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress | Q83862226 | ||
| FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) | Q24338668 | ||
| Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes | Q24645537 | ||
| Normal oxidative damage to mitochondrial and nuclear DNA is extensive | Q24649831 | ||
| Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial | Q24654699 | ||
| Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells | Q24810302 | ||
| Nitric oxide: physiology, pathophysiology, and pharmacology | Q26778243 | ||
| Aging: a theory based on free radical and radiation chemistry | Q27860549 | ||
| Oxidants, oxidative stress and the biology of ageing | Q28131725 | ||
| Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan | Q28203572 | ||
| Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 | Q28237795 | ||
| NF-kappaB: pivotal mediator or innocent bystander in atherogenesis? | Q28346544 | ||
| Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man | Q28359675 | ||
| A major role for VCAM-1, but not ICAM-1, in early atherosclerosis | Q28365883 | ||
| Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice | Q28584822 | ||
| Not all Shc's roads lead to Ras | Q28609214 | ||
| The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine | Q29547539 | ||
| The p66shc adaptor protein controls oxidative stress response and life span in mammals | Q29614553 | ||
| Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress | Q29615436 | ||
| Extrachromosomal rDNA circles--a cause of aging in yeast | Q29618308 | ||
| Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials | Q31056275 | ||
| Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels | Q33335053 | ||
| Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells | Q33667974 | ||
| Invited review: manganese superoxide dismutase in disease | Q33944740 | ||
| Endothelial dysfunction in diabetes. | Q33959485 | ||
| Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta | Q34246063 | ||
| Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology | Q34479807 | ||
| Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial | Q34569180 | ||
| Vascular targets of redox signalling in diabetes mellitus | Q34658408 | ||
| Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. | Q34763602 | ||
| Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing | Q35042816 | ||
| Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells | Q35553734 | ||
| Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. | Q35691127 | ||
| Age, hypertension and hypercholesterolaemia alter endothelium-dependent vascular regulation | Q35747383 | ||
| Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells | Q35822759 | ||
| SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase | Q35990346 | ||
| A common pathway for intracellular reactive oxygen species production by glycoxidative and nitroxidative stress in vascular endothelial cells and smooth muscle cells. | Q36203953 | ||
| Enhanced peroxynitrite formation is associated with vascular aging | Q36404553 | ||
| Stem cells and the regeneration of the aging cardiovascular system | Q36803362 | ||
| Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice | Q36853797 | ||
| Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms | Q36938449 | ||
| Inflammation and endothelial dysfunction during aging: role of NF-kappaB | Q36956379 | ||
| p66Shc-generated oxidative signal promotes fat accumulation | Q36990193 | ||
| Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein. | Q37046360 | ||
| Age as a modifiable risk factor for cardiovascular disease | Q37102653 | ||
| The role of p66Shc deletion in age-associated arterial dysfunction and disease states. | Q37261119 | ||
| Endothelium-dependent contractions: when a good guy turns bad! | Q37279644 | ||
| Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases | Q37282734 | ||
| Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice | Q37370688 | ||
| Endothelial dysfunction: the first step toward coronary arteriosclerosis | Q37395620 | ||
| DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite | Q37700756 | ||
| Endothelium-derived vasoactive substances: potential role in hypertension, atherosclerosis, and vascular occlusion | Q38208686 | ||
| Endothelium-derived nitric oxide, endothelin, and platelet vessel wall interaction: alterations in hypercholesterolemia and atherosclerosis. | Q40837710 | ||
| Hypertension, endothelium, and cardiovascular risk factors | Q41158946 | ||
| Free radicals, proteins and DNA: oxidative damage versus redox regulation | Q41271107 | ||
| Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immuno-stimulated J774.2 macrophages | Q41349785 | ||
| Diabetes-induced coronary vascular dysfunction involves increased arginase activity | Q41817278 | ||
| p66(shc) is highly expressed in fibroblasts from centenarians. | Q42480719 | ||
| The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism | Q42490911 | ||
| Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine | Q42536134 | ||
| Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion. | Q42600711 | ||
| Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. | Q42610778 | ||
| The calcium ionophore A23187 induces endothelium-dependent contractions in femoral arteries from rats with streptozotocin-induced diabetes. | Q42940211 | ||
| Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits | Q43652291 | ||
| Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy | Q43696104 | ||
| c-Jun N-terminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation | Q43767937 | ||
| Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function | Q44028489 | ||
| Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle | Q44233062 | ||
| Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature | Q44435413 | ||
| NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats | Q44547281 | ||
| Sirt1 regulates aging and resistance to oxidative stress in the heart | Q44830459 | ||
| Deletion of p66shc gene protects against age-related endothelial dysfunction | Q45124664 | ||
| Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress. | Q45161413 | ||
| Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha | Q45275088 | ||
| Protective role of SIRT1 in diabetic vascular dysfunction | Q46088107 | ||
| p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose | Q46100245 | ||
| Is the aging heart similar to the diabetic heart? Evaluation of LV function of the aging heart with Tissue Doppler Imaging | Q46118217 | ||
| Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma | Q46200093 | ||
| Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes | Q46396936 | ||
| Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells | Q46537885 | ||
| Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice | Q46649057 | ||
| Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. | Q46752037 | ||
| P433 | issue | 2 | |
| P921 | main subject | circulatory system | Q11068 |
| lifetime | Q22675021 | ||
| P304 | page(s) | 315-324 | |
| P577 | publication date | 2009-09-12 | |
| P1433 | published in | Pfluegers Archiv | Q1091689 |
| P1476 | title | Cardiovascular determinants of life span | |
| P478 | volume | 459 |
| Q34457087 | Age, race, diabetes, blood pressure, and mortality among hemodialysis patients |
| Q37739751 | Anti-aging medicine: molecular basis for endothelial cell-targeted strategies - a mini-review |
| Q37616776 | Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. |
| Q47282946 | Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury |
| Q34232959 | Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells |
| Q89477733 | Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease |
| Q46593121 | Nicotine Enhances High-Fat Diet-Induced Oxidative Stress in the Kidney |
| Q90418958 | Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats |
| Q48444883 | Protective Effect of Hyperbaric Oxygen on Cognitive Impairment Induced by D-Galactose in Mice |
| Q38267485 | Protective actions of melatonin and growth hormone on the aged cardiovascular system. |
| Q38258971 | Role of sirtuins in chronic obstructive pulmonary disease |
| Q47427319 | Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model |
| Q35768345 | Sirtuins, aging, and cardiovascular risks |
| Q88911120 | Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction |
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