A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources.

scientific article published on 24 February 2014

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SREP04160
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/srep04160
P932PMC publication ID3932448
P698PubMed publication ID24561821
P5875ResearchGate publication ID260374843

P50authorAbraham AlahmadQ43092495
P2093author name stringSean P Palecek
Eric V Shusta
Ethan S Lippmann
Samira M Azarin
P2860cites workThe blood-brain barrier: bottleneck in brain drug developmentQ22336985
Pericytes are required for blood-brain barrier integrity during embryogenesisQ24627396
A perivascular origin for mesenchymal stem cells in multiple human organsQ28131808
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin AQ28285192
Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.Q28507603
Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesisQ28594356
The blood-brain barrier in health and chronic neurodegenerative disordersQ29616411
Central nervous system pericytes in health and diseaseQ33609398
The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cellsQ33741896
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small moleculesQ33929545
Modelling of the blood-brain barrier in drug discovery and development.Q34005458
Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental studyQ34032708
Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrierQ34128009
SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrierQ34206194
Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrierQ34502705
17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activityQ34502756
Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosisQ34666702
Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids.Q52126162
Retinoid signalling acts during the gastrula stages to promote primary neurogenesis.Q52164327
mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.Q53519195
Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial CellsQ57283471
A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cordQ77983175
Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrierQ35029148
Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neuronsQ35341255
Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology.Q36166111
Derivation of blood-brain barrier endothelial cells from human pluripotent stem cellsQ36306295
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cellsQ36512766
Modeling the blood-brain barrier using stem cell sourcesQ36588683
Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistanceQ36959343
Self-organized vascular networks from human pluripotent stem cells in a synthetic matrixQ37068457
Differentiating embryonic neural progenitor cells induce blood-brain barrier propertiesQ37131752
Retinoic acid induces blood-brain barrier development.Q39205654
Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrierQ40015379
Blood-brain barrier-specific properties of a human adult brain endothelial cell lineQ40377619
Modulation of P-glycoprotein activity by glial factors and retinoic acid in an immortalized rat brain microvessel endothelial cell lineQ41076019
Induction of blood-brain barrier differentiation in a rat brain-derived endothelial cell lineQ41301625
An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identityQ41564030
A cell culture model of the blood-brain barrierQ42006322
Gene expression in human neural stem cells: effects of leukemia inhibitory factor.Q42443012
Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drugQ42496777
Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cellsQ44493503
A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytesQ45351723
Cerebrovascular permeability coefficients to sodium, potassium, and chlorideQ45876503
Closing the gap between the in-vivo and in-vitro blood-brain barrier tightness.Q45980701
Murine brain capillary endothelial cells exhibit improved barrier properties under the influence of hydrocortisoneQ46615513
Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane proteinQ48050043
Retinoid receptors promote primary neurogenesis in Xenopus.Q48055937
Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction.Q48599756
Electrical resistance of brain microvascular endothelium.Q48933784
Vitamin A-deficient quail embryos have half a hindbrain and other neural defects.Q49036731
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectblood–brain barrierQ221694
multicellularityQ110243984
P304page(s)4160
P577publication date2014-02-24
P1433published inScientific ReportsQ2261792
P1476titleA retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
P478volume4

Reverse relations

cites work (P2860)
Q270264573D in vitro modeling of the central nervous system
Q4712088096 perfusable blood vessels to study vascular permeability in vitro
Q92685913A Simplified, Fully Defined Differentiation Scheme for Producing Blood-Brain Barrier Endothelial Cells from Human iPSCs
Q89983564A dynamic perfusion based blood-brain barrier model for cytotoxicity testing and drug permeation
Q47830673A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis.
Q28543817A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems
Q47350712A simple cell transport device keeps culture alive and functional during shipping.
Q28539764A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells
Q92257741ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas
Q33560284Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells.
Q46115062Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells
Q43062537Advances in brain barriers and brain fluid research and news from Fluids and Barriers of the CNS.
Q26745911Advancing cardiovascular tissue engineering
Q66679557All Together Now: Modeling the Interaction of Neural With Non-neural Systems Using Organoid Models
Q42182270An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development.
Q42804873An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells.
Q92457828An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
Q38841460Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.
Q50177856Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier.
Q89947938Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn
Q59793802Benchmarking in vitro tissue-engineered blood-brain barrier models
Q90110906Biology of the human blood-nerve barrier in health and disease
Q30358385Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
Q47910464Blood-brain barrier dysfunction and recovery after ischemic stroke
Q35837961Blood-brain barrier modeling: challenges and perspectives
Q47970111Blood-brain barrier models derived from individual patients: a new frontier: An Editorial Highlight on 'An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cel
Q38267318Blood-brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics
Q90061953Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP)
Q55032220Brain vascular heterogeneity: implications for disease pathogenesis and design of in vitro blood-brain barrier models.
Q88465572Bridging barriers: a comparative look at the blood-brain barrier across organisms
Q28822276Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells
Q48218690Characterisation of human induced pluripotent stem cell-derived endothelial cells under shear stress using an easy-to-use microfluidic cell culture system.
Q47675024Comparative study of expression and activity of glucose transporters between stem cell-derived brain microvascular endothelial cells and hCMEC/D3 cells
Q60920173Comparison between Polybutylcyanoacrylate Nanoparticles with Either Surface-Adsorbed or Encapsulated Brain-Derived Neurotrophic Factor on the Neural Differentiation of iPSCs
Q34577527Concise review: tissue-specific microvascular endothelial cells derived from human pluripotent stem cells
Q47675953Controlling Differentiation of Stem Cells for Developing Personalized Organ-on-Chip Platforms.
Q46870120Cryopreservation of Brain Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Is Enhanced by Rho-Associated Coiled Coil-Containing Kinase Inhibition
Q93179088Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells
Q48126664Development of a direct contact astrocyte-human cerebral microvessel endothelial cells blood-brain barrier coculture model
Q33733071Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties
Q35827703Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells
Q47100977Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells
Q37110622Diverse Functions of Retinoic Acid in Brain Vascular Development.
Q89855148Drug Development for Central Nervous System Diseases Using In Vitro Blood-brain Barrier Models and Drug Repositioning
Q93099667Effect of heat stress on blood-brain barrier integrity in iPS cell-derived microvascular endothelial cell models
Q38695766Effect of shear stress on iPSC-derived human brain microvascular endothelial cells (dhBMECs).
Q36419596Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions.
Q89133438Endothelial cells are critical regulators of iron transport in a model of the human blood-brain barrier
Q90706949Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours
Q47163222Engineering the human blood-brain barrier in vitro
Q92962663Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood-brain barrier model
Q91811166Establishment of a Human Blood-Brain Barrier Co-Culture Model Mimicking the Neurovascular Unit Using Induced Pluripotent Stem Cells
Q40278164Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells.
Q35683426Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells
Q58696926Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body
Q49795132Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation.
Q28548080Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells
Q90146492Gliotoxin penetrates and impairs the integrity of the human blood-brain barrier in vitro
Q38779058Growth-factor reduced Matrigel source influences stem cell derived brain microvascular endothelial cell barrier properties
Q92843677HDL from an Alzheimer's disease perspective
Q28551318Human Brain Microvascular Endothelial Cells Derived from the BC1 iPS Cell Line Exhibit a Blood-Brain Barrier Phenotype
Q99589766Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development?
Q51416081Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development.
Q58552757Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior
Q64100139Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties
Q45611249Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits
Q88199451Hyaluronan impairs the barrier integrity of brain microvascular endothelial cells through a CD44-dependent pathway
Q35163849Hydrocortisone enhances the barrier properties of HBMEC/ciβ, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects
Q64900124Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies.
Q38758994In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs).
Q89057060In vitro models of molecular and nano-particle transport across the blood-brain barrier
Q64916610Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection.
Q64249247Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions
Q38730069In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use.
Q92587953Is there a central role for the cerebral endothelium and the vasculature in the brain response to conditioning stimuli?
Q48292903Isogenic blood-brain barrier models based on patient-derived stem cells display inter-individual differences in cell maturation and functionality
Q48629588Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening.
Q26747691Microfluidic organ-on-chip technology for blood-brain barrier research
Q57479119Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons
Q38666481Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells
Q45826985Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells
Q49601349Modeling Neurovascular Disorders and Therapeutic Outcomes with Human-Induced Pluripotent Stem Cells.
Q46205341Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier.
Q55055706Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients.
Q94064373Modeling the blood-brain barrier: Beyond the endothelial cells
Q89810596Modulation of in vitro Brain Endothelium by Mechanical Trauma: Structural and Functional Restoration by Poloxamer 188
Q38824367Morphogens and blood-brain barrier function in health and disease
Q30352890NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface.
Q38275050Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance
Q38381835Neuronal and vascular interactions.
Q97418952Neuronal regulation of the blood-brain barrier and neurovascular coupling
Q38991126New experimental models of the blood-brain barrier for CNS drug discovery.
Q92980146Nutritional supplementation of vitamin A and health-related outcomes in patients with multiple sclerosis: A protocol for a systematic review and meta-analysis of randomized clinical trials
Q93054814Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration
Q49569055Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease.
Q66679638Past and Current Perspectives in Modeling Bacteria and Blood-Brain Barrier Interactions
Q55240298Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier.
Q93068407Phase 0 Clinical Trial Strategies for the Neurosurgical Oncologist
Q91130089Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model
Q93160159Recent advances in human iPSC-derived models of the blood-brain barrier
Q36372454Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury
Q40306099Retinoic Acid Prevents Disruption of Blood-Spinal Cord Barrier by Inducing Autophagic Flux After Spinal Cord Injury
Q91886011Retinoic acid signaling in vascular development
Q64900504Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D.
Q41078810Serum retinol levels are associated with brain volume loss in patients with multiple sclerosis
Q93160323Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model
Q38597068Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering.
Q91735295Strategies for derivation of endothelial lineages from human stem cells
Q92755051Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
Q64899660Studying Heterotypic Cell⁻Cell Interactions in the Human Brain Using Pluripotent Stem Cell Models for Neurodegeneration.
Q92378165Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models
Q28086851TEER measurement techniques for in vitro barrier model systems
Q95840773The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier
Q41243197The Microvascular Gap Junction Channel: A Route to Deliver MicroRNAs for Neurological Disease Treatment
Q28087222The molecular constituents of the blood-brain barrier
Q91860762The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model
Q41440571Therapeutic strategies for spinal muscular atrophy: SMN and beyond.
Q47805415Tissue Engineering the Vascular Tree
Q41844621Tissue-engineered blood vessels as promising tools for testing drug toxicity.
Q92497246Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model
Q38801331Validation of an immortalized human (hBMEC) in vitro blood-brain barrier model
Q64249273iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds
Q47247599iPSCs-based generation of vascular cells: reprogramming approaches and applications.
Q35602819pH responsive granulocyte colony-stimulating factor variants with implications for treating Alzheimer's disease and other central nervous system disorders
Q48095983β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function

Search more.