Large animal models of heart failure: a critical link in the translation of basic science to clinical practice

scientific article published on May 2009

Large animal models of heart failure: a critical link in the translation of basic science to clinical practice is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1161/CIRCHEARTFAILURE.108.814459
P932PMC publication ID2762217
P698PubMed publication ID19808348

P2093author name stringFrancis G Spinale
Jennifer A Dixon
P2860cites workACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the [...]Q22306349
Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarctionQ24534652
Bone marrow cells regenerate infarcted myocardiumQ28210640
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarctionQ30824170
Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trialQ31033745
beta-adrenergic receptor blockade in chronic heart failureQ33831388
A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failureQ34106793
Effects of chronic beta-adrenergic blockade on the left ventricular and cardiocyte abnormalities of chronic canine mitral regurgitationQ34153068
Allogeneic mesenchymal precursor cell therapy to limit remodeling after myocardial infarction: the effect of cell dosageQ34491790
Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failureQ34632009
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and humanQ34968216
Assessment of hydraulic performance and biocompatibility of a MagLev centrifugal pump system designed for pediatric cardiac or cardiopulmonary supportQ35774656
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigsQ35894577
Proteomics in cardiovascular surgeryQ36697186
Structural basis for changes in left ventricular function and geometry because of chronic mitral regurgitation and after correction of volume overloadQ72622940
Early dilation of the infarcted segment in acute transmural myocardial infarction: Role of infarct expansion in acute left ventricular enlargementQ72818174
Differential effects of pressure or volume overload on myocardial MMP levels and inhibitory controlQ73377219
Levosimendan enhances left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathyQ73488742
Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failureQ73635731
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systemsQ73804446
Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodelingQ73944148
Device-based change in left ventricular shape: a new concept for the treatment of dilated cardiomyopathyQ74486719
Hemodynamic unloading of the failing left ventricle using an arterial-to-arterial extracorporeal flow circuitQ75271547
Extension of borderzone myocardium in postinfarction dilated cardiomyopathyQ78298435
Left ventricular reverse remodeling after surgical therapy for aortic stenosis: correlation to Renin-Angiotensin system gene expressionQ78299057
The promise of translational physiologyQ78946554
Hemodynamic properties of a new-generation positive luso-inotropic agent for the acute treatment of advanced heart failureQ79615255
Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failureQ80876154
Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarctionQ81435055
Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failureQ82332194
Gene therapy in heart failureQ36944623
The cardioprotective effects of levosimendan: preclinical and clinical evidenceQ36945501
Centrifugal pump or pneumatic ventricle for short-term mechanical circulatory support?Q38534835
Collagen in the hypertrophied, pressure-overloaded myocardiumQ39480503
Current status on the development of a totally implantable biventricular assist device: the Baylor Gyro BVAD.Q39677857
Transplantation of magnetically labeled mesenchymal stem cells improves cardiac function in a swine myocardial infarction modelQ40110783
Alterations of myocardial blood flow associated with experimental canine left ventricular hypertrophy secondary to valvular aortic stenosisQ41352895
The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flowQ41640497
The cellular basis for the blunted response to beta-adrenergic stimulation in supraventricular tachycardia-induced cardiomyopathyQ42503620
Effects of continuous aortic flow augmentation in patients with exacerbation of heart failure inadequately responsive to medical therapy: results of the Multicenter Trial of the Orqis Medical Cancion System for the Enhanced Treatment of Heart FailurQ44222374
Beta1-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitationQ44504031
Clinical evaluation of the CorCap Cardiac Support Device in patients with dilated cardiomyopathyQ44550947
Valsartan-induced cardioprotection involves angiotensin II type 2 receptor upregulation in dog and rat models of in vivo reperfused myocardial infarctionQ44766100
Percutaneous mitral annular reduction provides continued benefit in an ovine model of dilated cardiomyopathyQ45124620
Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia modelQ45218845
Differences between human and mouse embryonic stem cellsQ45345133
Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animalsQ45869517
Left ventricular adaptation to gradual renovascular hypertension in dogsQ46418417
Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog.Q46711745
Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic propertiesQ46799141
Intramyocardial injection of allogenic bone marrow-derived mesenchymal stem cells without immunosuppression preserves cardiac function in a porcine model of myocardial infarctionQ46871283
Infarct size and location determine development of mitral regurgitation in the sheep modelQ47291898
The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogsQ47325541
Reversal of Chronic Molecular and Cellular Abnormalities Due to Heart Failure by Passive Mechanical Ventricular ContainmentQ47438363
Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronizationQ47871785
Cardiac support device modifies left ventricular geometry and myocardial structure after myocardial infarction.Q51363806
A placebo controlled, dose-ranging, safety study of allogenic mesenchymal stem cells injected by endomyocardial delivery after an acute myocardial infarction.Q51724266
Injection of bone marrow mesenchymal stem cells in the borderline area of infarcted myocardium: heart status and cell distribution.Q51729624
Recovery of regional but not global contractile function by the direct intramyocardial autologous bone marrow transplantation: results from a randomized controlled clinical trial.Q51797011
Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial.Q53253372
Three-dimensional changes in left and right ventricular geometry in chronic mitral regurgitation.Q53612210
The pig as a model for myocardial ischemia and exercise.Q53802019
Salvage of ischaemic myocardium by reperfusion: importance of collateral blood flow and myocardial oxygen demand during occlusion.Q54145560
Bioenergetic and Functional Consequences of Bone Marrow-Derived Multipotent Progenitor Cell Transplantation in Hearts With Postinfarction Left Ventricular RemodelingQ56777840
Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failureQ57485430
Translational research: Crossing the valley of deathQ59063636
Myocardial Infarct Expansion and Matrix Metalloproteinase InhibitionQ59651627
Large animal model of left ventricular aneurysmQ61771910
A canine model of chronic heart failure produced by multiple sequential coronary microembolizationsQ67898469
Comparative evaluation of disk- and trileaflet valves in left-ventricular assist devices (LVAD)Q68366905
Volume overload hypertrophy in a closed-chest model of mitral regurgitationQ68404508
Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacementQ69295549
Left ventricular function in experimental volume overload hypertrophyQ69298012
A quantitative study of the anatomy and distribution of coronary arteries in swine in comparison with other animals and manQ69716989
Cardiorenal and neurohumoral function in a canine model of early left ventricular dysfunctionQ70743359
Angiotensin-converting enzyme inhibition and the progression of congestive cardiomyopathy. Effects on left ventricular and myocyte structure and functionQ71956027
Endothelin in human congestive heart failureQ72344120
Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fractionQ72523384
P433issue3
P921main subjectheart failureQ181754
P304page(s)262-271
P577publication date2009-05-01
P1433published inCirculation: Heart FailureQ2865806
P1476titleLarge animal models of heart failure: a critical link in the translation of basic science to clinical practice
P478volume2

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cites work (P2860)
Q33719810A Hyper-Crosslinked Carbohydrate Polymer Scaffold Facilitates Lineage Commitment and Maintains a Reserve Pool of Proliferating Cardiovascular Progenitors
Q61449743A Large Animal Model of Right Ventricular Failure due to Chronic Thromboembolic Pulmonary Hypertension: A Focus on Function
Q90668227A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse
Q51062814A Protocol for Collecting Human Cardiac Tissue for Research.
Q91433760A mouse model of heart failure exhibiting pulmonary edema and pleural effusion: Useful for testing new drugs
Q34669335A needleless liquid jet injection delivery method for cardiac gene therapy: a comparative evaluation versus standard routes of delivery reveals enhanced therapeutic retention and cardiac specific gene expression
Q39168641A new dual-promoter system for cardiomyocyte-specific conditional induction of apoptosis
Q37400718A nonthoracotomy myocardial infarction model in an ovine using autologous platelets
Q38240412A role for membrane shape and information processing in cardiac physiology
Q38344723Allogeneic cardiac stem cell administration for acute myocardial infarction
Q82488628Alteration of LV end-diastolic volume by controlling the power of the continuous-flow LVAD, so it is synchronized with cardiac beat: development of a native heart load control system (NHLCS)
Q47833650An Interposed Pad in Open-Chest Echocardiographic Porcine Scans for Mimicking Ultrasound Signal Attenuation in a Human Chest
Q38267810An overview on development and application of an experimental platform for quantitative cardiac imaging research in rabbit models of myocardial infarction
Q41389933Analysis of Serum Cholesterol Efflux Capacity in a Minipig Model of Nonischemic Heart Failure
Q26865437Animal and in silico models for the study of sarcomeric cardiomyopathies
Q37974118Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing
Q26797153Bedside-to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients Who Do Not Meet Trial Enrollment Criteria
Q36949129Benefits of standardizing the treatment of arrhythmias in the sheep (Ovis aries) model of chronic heart failure after myocardial infarction
Q39713637Biomechanical Properties and Microstructure of Heart Chambers: A Paired Comparison Study in an Ovine Model
Q34479363Bovine model of doxorubicin-induced cardiomyopathy
Q36822346Brain growth of the domestic pig (Sus scrofa) from 2 to 24 weeks of age: a longitudinal MRI study
Q28243737Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model
Q41129527Cardiac Myosin Activation with Gene Therapy Produces Sustained Inotropic Effects and May Treat Heart Failure with Reduced Ejection Fraction
Q99568295Cardiac output improvement by pecavaptan: A novel dual-acting vasopressin V1a/V2 receptor antagonist in experimental heart failure
Q34617472Cardiac regeneration using pluripotent stem cells--progression to large animal models.
Q39310120Cardiac stem cells: translation to human studies.
Q38546856Cardioprotection in ischaemia-reperfusion injury: novel mechanisms and clinical translation
Q58478037Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
Q57818505Cardiovascular disease models: A game changing paradigm in drug discovery and screening
Q26779676Cardiovascular imaging: what have we learned from animal models?
Q37731205Challenges in using stem cells for cardiac repair
Q45421871Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models
Q90405130Clinical overview of the HVAD: a centrifugal continuous-flow ventricular assist device with magnetic and hydrodynamic bearings including lateral implantation strategies
Q58802723Common swine models of cardiovascular disease for research and training
Q64997487Comprehensive Characterization of Swine Cardiac Troponin T Proteoforms by Top-Down Mass Spectrometry.
Q33613128Construction of a cDNA library for miniature pig mandibular deciduous molars
Q34405482Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes
Q89123147Decreased contractility and altered responses to inotropic agents in myocytes from tachypacing-induced heart failure canines
Q37731623Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest
Q30557205Development of a closed chest model of chronic myocardial infarction in Swine: magnetic resonance imaging and pathological evaluation
Q85937226Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat
Q35159927Development of a preclinical model of ischemic cardiomyopathy in swine
Q48612322Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry
Q89782554Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies
Q90169667ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease
Q38178645Endogenous cardiac stem cells for the treatment of heart failure
Q26744575Engineered Swine Models of Cancer
Q90718914Engineering hiPSC cardiomyocyte in vitro model systems for functional and structural assessment
Q96955294Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary artery constriction model
Q38423857Extracellular matrix communication and turnover in cardiac physiology and pathology
Q36365384Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes
Q38302660Gene reprogramming in exercise-induced cardiac hypertrophy in swine: A transcriptional genomics approach.
Q26798712Genetics of Human and Canine Dilated Cardiomyopathy
Q52581669Genome Editing and Induced Pluripotent Stem Cell Technologies for Personalized Study of Cardiovascular Diseases.
Q49073906Global and regional wall motion abnormalities of pacing-induced heart failure assessed by multi-detector row CT: a patient and canine model study
Q90405173How to do it: tips and tricks of minimal-invasive HVAD® implantation-the lateral approach
Q92663895Human Induced Pluripotent Stem Cells Derived from a Cardiac Somatic Source: Insights for an In-Vitro Cardiomyocyte Platform
Q34133412Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
Q28081697Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes
Q35849561Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries)
Q30413268Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells
Q91867469Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations
Q36364300In search of new therapeutic targets and strategies for heart failure: recent advances in basic science
Q37071104In vitro comparison of Doppler and catheter-measured pressure gradients in 3D models of mitral valve calcification
Q35957030Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock
Q38267844Insights into RNA transcriptome profiling of cardiac tissue in obesity and hypertension conditions
Q37406111Integrating the myocardial matrix into heart failure recognition and management
Q35844633Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy
Q36787202Investigation of MMP-2 and MMP-9 activities in canine sera with dilated cardiomyopathy
Q53032907Ischemia-induced model of diastolic dysfunction in sheep.
Q37660159Isolated effect of geometry on mitral valve function for in silico model development
Q52866940Isolation of Pig Bone Marrow-Derived Mesenchymal Stem Cells.
Q57578159Isolation, Characterization and Differentiation Potential of Cardiac Progenitor Cells in Adult Pigs
Q36713333Isolation, Characterization, and Spatial Distribution of Cardiac Progenitor Cells in the Sheep Heart
Q93048686Large Animal Models of Heart Failure With Reduced Ejection Fraction (HFrEF)
Q38886473Large animal model of functional tricuspid regurgitation in pacing induced end-stage heart failure.
Q26766350Large animal models of cardiovascular disease
Q35587392Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach.
Q35194787Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction
Q35396651Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy
Q37648508M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics
Q48704464Magnetic resonance imaging of the neonatal piglet brain
Q92326034Main histological parameters to be evaluated in an experimental model of myocardial infarct treated by stem cells on pigs
Q47119099Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials
Q26823061Model-specific selection of molecular targets for heart failure gene therapy
Q92302079Modeling heart failure in animal models for novel drug discovery and development
Q36738466Models for preclinical studies in aging-related disorders: One is not for all.
Q30274835Multiparametric CMR imaging of infarct remodeling in a percutaneous reperfused Yucatan mini-pig model
Q30362840Myocardial fibrosis: biomedical research from bench to bedside.
Q36396792Neuroanatomy of the Pig Cardiac Ventricles. A Stereomicroscopic, Confocal and Electron Microscope Study
Q30811829Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care
Q50968776Optimized method for isolating highly purified and functional porcine aortic endothelial and smooth muscle cells.
Q38097512Perspective and challenges of mesenchymal stem cells for cardiovascular regeneration.
Q28534595Porcine adipose tissue-derived mesenchymal stem cells retain their proliferative characteristics, senescence, karyotype and plasticity after long-term cryopreservation
Q88219970Preclinical Studies of Stem Cell Therapy for Heart Disease
Q38087578Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
Q37232553Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction
Q47780593Prophylactic and therapeutic effects of garlic extract on Nerium oleander-induced arrhythmia: a new approach to antiarrhythmic therapy in an ovine model
Q57396450Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
Q33680476Proteomics in heart failure: top-down or bottom-up?
Q90727956Quantitative Proteomic and Phosphoproteomic Profiling of Ischemic Myocardial Stunning in Swine
Q35185962Real-time cardiac metabolism assessed with hyperpolarized [1-(13) C]acetate in a large-animal model
Q37828115Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies
Q35586219Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
Q36510256Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: pilot study in a porcine animal model
Q49098158Response to exercise and mechanical efficiency in non-ischaemic stunning, induced by short-term rapid pacing in dogs: a role for calcium?
Q28291290S100A1 gene therapy for heart failure: A novel strategy on the verge of clinical trials
Q88631526Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovisaries)
Q36364241Sex differences in porcine left ventricular myocardial remodeling due to right ventricular pacing.
Q89176614Size-Dependent Ability of Liposomes to Accumulate in the Ischemic Myocardium and Protect the Heart
Q28658055Small and large animal models in cardiac contraction research: advantages and disadvantages
Q52649058Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine.
Q99593598Targeted Injection of a Truncated Form of Tissue Inhibitor of Metalloproteinase 3 Alters Post-MI Remodeling
Q37878086Targeted gene therapy for the treatment of heart failure
Q41829618Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction
Q26766151The cardiac enigma: current conundrums in heart failure research
Q64120212The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense
Q38616615The pathophysiology of pulmonary hypertension in left heart disease
Q30567453The use of gadolinium-carbon nanostructures to magnetically enhance stem cell retention for cellular cardiomyoplasty
Q36873848The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart
Q41890749Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model
Q34303423Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction
Q33728779Translation of Cardiac Myosin Activation with 2-deoxy-ATP to Treat Heart Failure via an Experimental Ribonucleotide Reductase-Based Gene Therapy
Q37052256Translation of Methodology Used In Human Myocardial Imaging to a Sheep Model of Acute Myocardial Infarction
Q90267617Translational Models of Arrhythmia Mechanisms and Susceptibility: Success and Challenges of Modeling Human Disease
Q39447181Use of Adeno-Associated Virus Vector for Cardiac Gene Delivery in Large-Animal Surgical Models of Heart Failure
Q43499984Validation of admittance computed left ventricular volumes against real-time three-dimensional echocardiography in the porcine heart.
Q51325083What Is the Optimal Setting for a Continuous-Flow Left Ventricular Assist Device in Severe Mitral Regurgitation?
Q30560369Zebrafish heart failure models for the evaluation of chemical probes and drugs