Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

scientific article

Distinct signaling programs control human hematopoietic stem cell survival and proliferation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2016-09-740654
P932PMC publication ID5271174
P698PubMed publication ID27827829

P50authorConnie EavesQ5161848
Weijia WangQ56418846
David KnappQ57031305
Peter W ZandstraQ59982739
Garry P. NolanQ89180933
Nima AghaeepourQ97905004
Philip A BeerQ117259848
Guy SauvageauQ28873810
Richard HumphriesQ39614832
P2093author name stringCarl Hansen
Karen Sachs
Sean C Bendall
Paul H Miller
Davide Pellacani
Wenlian Qiao
Colin A Hammond
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Primary structure and functional expression of rat and human stem cell factor DNAsQ24297190
Principles of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuumQ24594356
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implicationsQ24617091
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem CellsQ24630871
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferationQ28119207
Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathwayQ28274808
A role for Wnt signalling in self-renewal of haematopoietic stem cellsQ28592213
Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cellsQ42943833
A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.Q43010395
STAT3 paradoxically stimulates β-catenin expression but inhibits β-catenin functionQ43093190
Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progressionQ43112746
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.Q46615053
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.Q50676184
Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development.Q51906537
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomasQ59077136
Mast cell growth factor, a ligand for the receptor encoded by c-kit, affects the growth in culture of the blast cells of acute myeloblastic leukemiaQ67692746
Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signalingQ83392308
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.Q33871498
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiledQ33941375
The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl-Sld.Q34230805
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.Q34356904
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophyQ34356914
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptorQ34567286
Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG miceQ34986162
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophyQ35011497
Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell poolQ35029942
Regulation of Wnt/beta-catenin signaling by protein kinasesQ35215312
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewalQ35263804
Cytokine manipulation of primitive human hematopoietic cell self-renewalQ36145824
Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietinQ36366808
Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo cultureQ36380522
Attenuation of miR-126 activity expands HSC in vivo without exhaustion.Q36455274
Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathwaysQ36457006
Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.Q36557199
Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid miceQ36576511
Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.Q36663582
Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone GraftQ36938847
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinasesQ38053052
Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapyQ38193659
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseasesQ38272835
Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansionQ38617784
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in miceQ39206146
Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancerQ40304208
Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genesQ41144957
Roles of Stat3 and ERK in G-CSF signalingQ42473466
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)307-318
P577publication date2016-11-08
P1433published inBloodQ885070
P1476titleDistinct signaling programs control human hematopoietic stem cell survival and proliferation
P478volume129

Reverse relations

cites work (P2860)
Q64085881A topological view of human CD34 cell state trajectories from integrated single-cell output and proteomic data
Q48249518Brief Report: A Differential Transcriptomic Profile of Ex Vivo Expanded Adult Human Hematopoietic Stem Cells Empowers Them for Engraftment Better than Their Surface Phenotype.
Q55139805CREB promotes laryngeal cancer cell migration via MYCT1/NAT10 axis.
Q37583700Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells
Q50884579Expression of embryonic stem cell markers in acute myeloid leukemia.
Q92819443Fate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs
Q29147543Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation
Q91899883Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks
Q48569638Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.
Q92094127Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells
Q42777547Single cell analysis of normal and leukemic hematopoiesis
Q38672557Single-cell analyses to reveal hematopoietic stem cell fate decisions
Q88867802Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential
Q48502210Tracking the origin, development, and differentiation of hematopoietic stem cells

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