NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism.

scientific article published on 14 March 2013

NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PATH.4171
P8608Fatcat IDrelease_7uswmfwmjzadli6u2bnuoixxfe
P932PMC publication ID3940725
P698PubMed publication ID23338972
P5875ResearchGate publication ID234824356

P50authorCholadda V CurryQ80852119
P2093author name stringLixia Diao
Hesham M Amin
Haifeng Zhu
Deeksha Vishwamitra
Roxsan Manshouri
Aarish Khan
P2860cites workALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)Q24336482
Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicityQ24522838
Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaBQ24534564
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)Q24595848
miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytesQ24596915
Widespread microRNA repression by Myc contributes to tumorigenesisQ24647067
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.Q24816506
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell deathQ28202067
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphomaQ28250347
MicroRNA-26a promotes cholangiocarcinoma growth by activating β-cateninQ28263940
MYC stimulates EZH2 expression by repression of its negative regulator miR-26aQ28291303
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activationQ46599708
Flavopiridol-induced iNOS downregulation during apoptosis of chronic lymphocytic leukemia cells is caspase-dependent.Q46915666
Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas.Q54572569
IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells.Q54788828
Nitric oxide signaling: a possible role for G proteinsQ72651333
Involvement of nitric oxide in farnesyltransferase inhibitor-mediated apoptosis in chronic myeloid leukemia cellsQ73316158
Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomasQ73937573
Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levelsQ28368070
Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulationQ28585425
Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growthQ30156817
Ubiquitination of inducible nitric oxide synthase is required for its degradationQ34155970
Loss of inducible nitric oxide synthase expression in the mouse renal cell carcinoma cell line RENCA is mediated by microRNA miR-146aQ34162507
Role of nitric oxide in carcinogenesis and tumour progressionQ34570058
MicroRNA expression profiling using microarraysQ34767925
DNA deaminating ability and genotoxicity of nitric oxide and its progenitorsQ34983829
The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death.Q35851325
MicroRNA 96 is a post-transcriptional suppressor of anaplastic lymphoma kinase expressionQ35951821
Pathobiology of ALK+ anaplastic large-cell lymphomaQ36007756
Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphomaQ36065849
Calmodulin is a subunit of nitric oxide synthase from macrophagesQ36231600
Assays for nitric oxide expression.Q36234664
The role of nitric oxide in tumour progressionQ36516414
The anaplastic lymphoma kinase in the pathogenesis of cancerQ37039605
iNOS as a therapeutic target for treatment of human tumorsQ37178499
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancerQ37198891
IGF-IR tyrosine kinase interacts with NPM-ALK oncogene to induce survival of T-cell ALK+ anaplastic large-cell lymphoma cellsQ37271044
The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signalingQ38299315
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic targetQ38326252
Inducible nitric oxide synthase (iNOS) expression and its prognostic value in prostate cancerQ38458827
miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.Q39449882
MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpressionQ39562983
Inhibition of lipopolysaccharide-induced nitric oxide synthesis by nicotine through S6K1-p42/44 MAPK pathway and STAT3 (Ser 727) phosphorylation in Raw 264.7 cellsQ39947779
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathwayQ40410769
iNOS initiates and sustains metabolic arrest in hypoxic lung adenocarcinoma cells: mechanism of cell survival in solid tumor coreQ40420785
Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase geneQ40444994
Inducible nitric oxide synthase-mediated proliferation of a T lymphoma cell line.Q40666204
Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathwayQ40838398
The activated anaplastic lymphoma kinase increases cellular proliferation and oncogene up-regulation in rat 1a fibroblasts.Q41086595
B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity.Q42458757
Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformationQ42833922
Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice.Q42835098
Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphomaQ43665317
NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.Q44211040
Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditionsQ44628915
The STAT3 DNA-binding domain mediates interaction with NF-kappaB p65 and inducible nitric oxide synthase transrepression in mesangial cellsQ44772804
P433issue1
P921main subjectmicroRNAQ310899
P304page(s)82-94
P577publication date2013-03-14
P1433published inJournal of PathologyQ400296
P1476titleNPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism
P478volume230

Reverse relations

cites work (P2860)
Q38184584ALK-positive cancer: still a growing entity.
Q41786278Concentration of circulating miRNA-containing particles in serum enhances miRNA detection and reflects CRC tissue-related deregulations.
Q38644718Crosstalk between microRNA and DNA Methylation Offers Potential Biomarkers and Targeted Therapies in ALK-Positive Lymphomas
Q38190915Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias
Q37690218Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism.
Q47762719MiR-26a functions as a tumor suppressor in ambient particulate matter-bound metal-triggered lung cancer cell metastasis by targeting LIN28B-IL6-STAT3 axis
Q92258573Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis
Q64064052The Potential Role of iNOS in Ovarian Cancer Progression and Chemoresistance
Q35556180The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma
Q86893123microRNA in Malignant Lymphoma
Q36741352microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production

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