Electrophysiological and morphological evidence for synchronized GnRH pulse generator activity among Kisspeptin/neurokinin B/dynorphin A (KNDy) neurons in goats

scientific article published on 19 October 2012

Electrophysiological and morphological evidence for synchronized GnRH pulse generator activity among Kisspeptin/neurokinin B/dynorphin A (KNDy) neurons in goats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1262/JRD.2012-136
P932PMC publication ID3943231
P698PubMed publication ID23080371

P2093author name stringYuji Mori
Takashi Yamamura
Yoshihiro Wakabayashi
Hiroaki Okamura
Kohei Sakamoto
P2860cites workDiscovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulationQ24629064
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54Q24685744
Kisspeptin signaling in the brainQ28259280
Chronic recording of electrophysiological manifestation of the hypothalamic gonadotropin-releasing hormone pulse generator activity in the goatQ48744482
Hypothalamic structures of the goat on stereotaxic coordinates.Q50761391
The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat.Q51385117
Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats.Q51498972
Effects of brief exposure of male pheromone on multiple-unit activity at close proximity to kisspeptin neurons in the goat arcuate nucleus.Q51530275
Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median EminenceQ58853638
Patterns of hypophysiotropic signals and gonadotropin secretion in the rhesus monkeyQ71536919
Identification of neurokinin B-expressing neurons as an highly estrogen-receptive, sexually dimorphic cell group in the ovine arcuate nucleusQ73218587
Morphological evidence for direct interaction between kisspeptin and gonadotropin-releasing hormone neurons at the median eminence of the male goat: an immunoelectron microscopic studyQ82675106
Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretionQ28283342
Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female ratsQ28575729
Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleusQ28749270
Ultrastructural Evidence of Kisspeptin-Gonadotrophin-Releasing Hormone (GnRH) Interaction in the Median Eminence of Female Rats: Implication of Axo-Axonal Regulation of GnRH ReleaseQ29030172
Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weightQ30419024
Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouseQ30424215
Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat.Q30432921
Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cellsQ33537663
Neurokinin 3 receptor immunoreactivity in the septal region, preoptic area and hypothalamus of the female sheep: colocalisation in neurokinin B cells of the arcuate nucleus but not in gonadotrophin-releasing hormone neurones.Q33652453
Pathway tracing using biotinylated dextran aminesQ33924970
Neurokinin B and the hypothalamic regulation of reproductionQ34354034
Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alphaQ34514612
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproductionQ34902985
Mechanisms of Disease: the first kiss-a crucial role for kisspeptin-1 and its receptor, G-protein-coupled receptor 54, in puberty and reproductionQ36577024
Single unit components of the hypothalamic multiunit electrical activity associated with the central signal generator that directs the pulsatile secretion of gonadotropic hormonesQ36603560
Metastin/kisspeptin and control of estrous cycle in ratsQ36766508
An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivoQ36796635
Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopyQ36908884
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.Q37174107
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouseQ37475488
Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus.Q37800630
Hypothalamic pulse generatorsQ39830785
The neuroendocrine control of the menstrual cycle.Q40258390
Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheepQ42457788
Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat.Q42467752
Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neuronsQ43715222
Labeling of central projections of primary afferents in adult rats: a comparison between biotinylated dextran amine, neurobiotin and Phaseolus vulgaris-leucoagglutininQ43805014
Colocalization of progesterone receptors in parvicellular dynorphin neurons of the ovine preoptic area and hypothalamusQ44193786
Interactions between the Noradrenergic and Opioid Peptidergic Systems in Controlling the Electrical Activity of Luteinizing Hormone-Releasing Hormone Pulse Generator in Ovariectomized RatsQ44335762
Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat.Q44871932
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.Q44932139
Evidence that projections from the bed nucleus of the stria terminalis and from the lateral and medial regions of the preoptic area provide input to gonadotropin releasing hormone (GNRH) neurons in the female sheep brainQ46414501
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouseQ46438750
Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin-releasing hormone pulse generator activity in the female rat.Q46862851
KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season.Q48329788
Central administration of neurokinin B activates kisspeptin/NKB neurons in the arcuate nucleus and stimulates luteinizing hormone secretion in ewes during the non-breeding seasonQ48379851
Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neuronsQ48386411
Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neuronsQ48426102
Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleusQ48443918
Effects of various types of hypothalamic deafferentation on luteinizing hormone pulses in ovariectomized ratsQ48640889
P433issue1
P921main subjectdynorphinQ324076
electrophysiologyQ1154774
P304page(s)40-48
P577publication date2012-10-19
P1433published inJournal of Reproduction and DevelopmentQ2203016
P1476titleElectrophysiological and morphological evidence for synchronized GnRH pulse generator activity among Kisspeptin/neurokinin B/dynorphin A (KNDy) neurons in goats
P478volume59

Reverse relations

cites work (P2860)
Q35049408A population of kisspeptin/neurokinin B neurons in the arcuate nucleus may be the central target of the male effect phenomenon in goats
Q37685929A role for neurokinin B in pulsatile GnRH secretion in the ewe.
Q36679472Chronic oestradiol reduces the dendritic spine density of KNDy (kisspeptin/neurokinin B/dynorphin) neurones in the arcuate nucleus of ovariectomised Tac2-enhanced green fluorescent protein transgenic mice
Q35161008Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats
Q30384411Electrophysiology of arcuate neurokinin B neurons in female Tac2-EGFP transgenic mice.
Q90281861Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe
Q89955496Importance of neuroanatomical data from domestic animals to the development and testing of the KNDy hypothesis for GnRH pulse generation
Q59447487KNDy Cells Revisited
Q36164309KNDy Neurons Modulate the Magnitude of the Steroid-Induced Luteinizing Hormone Surges in Ovariectomized Rats.
Q37240188Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes
Q47102783Mapping of KNDy neurons and immunohistochemical analysis of the interaction between KNDy and substance P neural systems in goat
Q28602493The Distribution of Substance P and Kisspeptin in the Mediobasal Hypothalamus of the Male Rhesus Monkey and a Comparison of Intravenous Administration of These Peptides to Release GnRH as Reflected by LH Secretion
Q55360047The Emerging Role(s) for Kisspeptin in Metabolism in Mammals.
Q91812134The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus
Q34243964The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1).

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