Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

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Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.5740-08.2009
P3181OpenCitations bibliographic resource ID1394819
P932PMC publication ID3035813
P698PubMed publication ID19321788
P5875ResearchGate publication ID24234621

P50authorIain J ClarkeQ63214236
Robert P. MillarQ38304462
Manuel Tena-SempereQ38359120
Jeremy T. SmithQ45933621
Antonia K RoseweirQ57191610
P2093author name stringRobert A Steiner
Suzanne M Moenter
Alexander S Kauffman
Justyna Pielecka-Fortuna
Kevin Morgan
Michelle L Gottsch
Ei Terasawa
Kathryn A Guerriero
Rafael Pineda
P2860cites workHypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54Q24685744
FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54Q28202614
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54Q28206906
The GPR54 gene as a regulator of pubertyQ28211950
Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cellsQ28213095
Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblastsQ28250454
Gonadotropin-releasing hormone receptorsQ28256257
KiSS-1, a novel human malignant melanoma metastasis-suppressor geneQ28298463
Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cellsQ28564333
Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female ratsQ28575729
Estradiol-sensitive afferents modulate long-term episodic firing patterns of GnRH neuronsQ30309366
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male RatQ58684160
Intracerebroventricular injections in mice. Some methodological refinementsQ69669104
Luteinizing hormone releasing hormone (LHRH) neuroterminals mapped using the push-pull perfusion method in the rhesus monkeyQ70243051
Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomized ewesQ70492590
The role of neuropeptide Y (NPY) in the control of LH secretion in the ewe with respect to season, NPY receptor subtype and the site of action in the hypothalamusQ70844760
Algorithms for the study of episodic hormone secretionQ71840403
Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humansQ78945845
Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54Q79428657
Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- miceQ80535476
Diurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activityQ30438409
Effect of steroid milieu on gonadotropin-releasing hormone-1 neuron firing pattern and luteinizing hormone levels in male miceQ30439402
Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiolQ30439925
The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndromeQ30440354
Neonatal lipopolysaccharide exposure exacerbates stress-induced suppression of luteinizing hormone pulse frequency in adulthood.Q36426958
Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axisQ36500694
Microdialysis methods for in vivo neuropeptide measurement in the stalk-median eminence in the Rhesus monkeyQ36661333
An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivoQ36796635
The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproductionQ36995554
Differential role of melanocortins in mediating leptin's central effects on feeding and reproductionQ38316328
Rapid photoperiod-induced increase in detectable GnRH mRNA-containing cells in Siberian hamsterQ39458786
Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screeningQ40176909
A role for kisspeptin in islet functionQ40257928
Gonadotropin-releasing hormone and its analogsQ40759688
A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouseQ44315330
Effect of restricted feeding on the concentrations of growth hormone (GH), gonadotropins, and prolactin (PRL) in plasma, and on the amounts of messenger ribonucleic acid for GH, gonadotropin subunits, and PRL in the pituitary glands of adult ovariecQ44705672
Female pheromones stimulate release of luteinizing hormone and testosterone without altering GnRH mRNA in adult male Syrian hamsters (Mesocricetus auratus).Q45056506
Identification of Tyr(290(6.58)) of the human gonadotropin-releasing hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: importance for high-affinity binding and receptor activationQ46389997
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouseQ46438750
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.Q47289867
Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphologyQ47901726
Hypothalamic gonadotrophin-releasing hormone expression in female monkeys with different sensitivity to stressQ48111143
Environmental control of kisspeptin: implications for seasonal reproductionQ48329777
Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback.Q48423835
Kisspeptin mediates the photoperiodic control of reproduction in hamstersQ48430510
Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutritionQ48486408
Pulsatile luteinizing hormone secretion in hypothalamic amenorrhea, anorexia nervosa, and polycystic ovarian disease during naltrexone treatmentQ48497933
Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.Q50745717
Structure-activity relationship study on small peptidic GPR54 agonists.Q51805389
Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels.Q52005264
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54.Q52086697
Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.Q52578645
Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54Q58326281
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3920-3929
P577publication date2009-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleDiscovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
P478volume29

Reverse relations

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