S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability

scientific article published on 20 February 2014

S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CDDIS.2014.31
P932PMC publication ID3944248
P698PubMed publication ID24556685
P5875ResearchGate publication ID260370934

P2093author name stringM Kaminska
P B Mullan
Z D'Costa
N E Buckley
P2860cites workNIH Image to ImageJ: 25 years of image analysisQ23319322
BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible geneQ24294911
S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeatsQ24301261
A Pin1/mutant p53 axis promotes aggressiveness in breast cancerQ24312083
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasisQ24312492
Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylationQ24313442
Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.Q24535931
Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatmentQ24562633
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypesQ24647928
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1Q28115843
Intracellular and extracellular roles of S100 proteinsQ28184555
Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2Q28212276
Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilizationQ28212970
X chromosomal abnormalities in basal-like human breast cancerQ28296876
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 databaseQ29616468
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapiesQ29617680
Expression of calcium-binding protein S100A2 in breast lesionsQ30961562
Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assayQ33622653
The role of mutant p53 in human cancerQ34153014
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.Q34190044
Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesionsQ34437144
Detection of the p53 response in zebrafish embryos using new monoclonal antibodiesQ34660684
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activationQ36187310
The role of BRCA1 in transcriptional regulation and cell cycle controlQ36602565
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a lossQ36649149
BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancersQ37224721
Hsp90, an unlikely ally in the war on cancerQ37274497
17 AAG for HSP90 inhibition in cancer--from bench to bedsideQ37550778
Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site.Q38621771
Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein)Q39205717
BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancersQ39436579
Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.Q40052411
A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63.Q40198186
Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma.Q40243783
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.Q40297038
The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity.Q40412703
The 2,5 oligoadenylate synthetase/RNaseL pathway is a novel effector of BRCA1- and interferon-gamma-mediated apoptosisQ40412826
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradationQ40418287
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitorsQ40631570
Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chainQ42185907
Localization of Ca(2+)-binding S100 proteins in epithelial tumours of the skinQ42450706
The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancerQ42484627
HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.Q45387477
Chaperone-dependent stabilization and degradation of p53 mutantsQ46788559
S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation.Q52027067
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.Q52561781
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.Q52564601
Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers.Q53360582
Immunohistochemical localization of the Ca2+binding S100 proteins in normal human skin and melanocytic lesionsQ56016553
Gene-Expression Profiles in Hereditary Breast CancerQ57240053
Stabilization of the MDM2 oncoprotein by mutant p53Q64380171
The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 associationQ73171130
Prognostic significance of BRCA1 expression in Japanese sporadic breast carcinomasQ74156976
Transcriptional activation of the human S100A2 promoter by wild-type p53Q74643574
Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53Q84696189
P4510describes a project that usesImageJQ1659584
P304page(s)e1070
P577publication date2014-02-20
P1433published inCell Death and DiseaseQ2197222
P1476titleS100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability
P478volume5

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cites work (P2860)
Q38788928A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer
Q38424946Epigenetic silencing of S100A2 in bladder and head and neck cancers
Q35793756Low spinophilin expression enhances aggressive biological behavior of breast cancer.
Q90671019Pin1 plays a key role in the response to treatment and clinical outcome in triple negative breast cancer
Q60044321Prognostic values of S100 family members in ovarian cancer patients
Q58701866Simvastatin functions as a heat shock protein 90 inhibitor against triple-negative breast cancer
Q36182254TAp73 transcriptionally represses BNIP3 expression.
Q42016261The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain

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