A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential

scientific article published on December 2004

A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.72.12.7084-7095.2004
P932PMC publication ID529100
P698PubMed publication ID15557632

P50authorSteven J. NorrisQ40830286
Jeffrey K. ActorQ41487064
P2093author name stringChinnaswamy Jagannath
Robert L Hunter
Lisa Y Armitige
Audrey Wanger
Eliud Sepulveda
Robert H Copenhaver
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Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelopeQ28486853
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Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyaseQ28486974
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosisQ28487225
Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosisQ28487409
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Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigHQ34032570
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Cord factor (alpha,alpha-trehalose 6,6'-dimycolate) inhibits fusion between phospholipid vesiclesQ35013655
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Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in miceQ36371162
Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressorQ36559920
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Naive human T cells develop into Th1 effectors after stimulation with Mycobacterium tuberculosis-infected macrophages or recombinant Ag85 proteinsQ39517273
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"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage formsQ42554386
Vaccinating Properties of Avirulent Dissociates of Five Different Strains of Tubercle BacilliQ42624390
Immunogenicity and protective efficacy of a tuberculosis DNA vaccineQ44024302
A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.Q44130148
A mouse model of the recrudescence of latent tuberculosis in the elderlyQ44175884
Mycobacterial pathogenesis: a historical perspectiveQ46441006
A flash-type bioluminescent immunoassay that is more sensitive than radioimaging: quantitative detection of cytokine cDNA in activated and resting human cellsQ48001671
Protection against murine tuberculosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the 30-kDa antigen of Mycobacterium bovis BCG.Q50121898
Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice.Q52548604
Deletion of the putative antioxidant noxR1 does not alter the virulence of Mycobacterium tuberculosis H37Rv.Q53902694
Inactivation of the Mycobacterium tuberculosis Nramp orthologue (mntH) does not affect virulence in a mouse model of tuberculosis.Q53977031
Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complexQ57203149
The mycobacterial antigens 85 complex – from structure to function and beyond: ResponseQ63369545
Mycobacterium tuberculosis Is Strikingly More Virulent for Mice When Given via the Respiratory than via the Intravenous RouteQ71829829
Relationship of survival, organism containment, and granuloma formation in acute murine tuberculosisQ73146285
Enhancement of immunocompetence in tuberculosis by DNA vaccinationQ73480299
Toxicity of nitrogen oxides and related oxidants on mycobacteria: M. tuberculosis is resistant to peroxynitrite anionQ73488662
The immunogenicity of single and combination DNA vaccines against tuberculosisQ73544810
A role for complement C5 in organism containment and granulomatous response during murine tuberculosisQ73773015
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium tuberculosisQ130971
P304page(s)7084-7095
P577publication date2004-12-01
P1433published inInfection and ImmunityQ6029193
P1476titleA mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential
P478volume72

Reverse relations

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