Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.

scientific article published on December 1995

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/J.1460-2075.1995.TB00313.X
P932PMC publication ID394747
P698PubMed publication ID8557042

P2093author name stringX Shi
R Lieberson
J Ong
L A Eckhardt
P2860cites workIsolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activityQ24612623
The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase geneQ24632148
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genesQ29547355
Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell lineQ33644611
Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiationQ34742867
Evidence for transient requirement of the IgH enhancerQ35295124
Mouse immunoglobulin genes: a bacterial plasmid containing the entire coding sequence for a pre-γ 2a heavy chainQ35618283
Nuclear matrix attachment occurs in several regions of the IgH locusQ35839296
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locusQ35914587
Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytomaQ36254206
Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cisQ36257612
Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunitsQ36270327
Unequal sister chromatid exchange. A mechanism affecting Ig gene arrangement and expressionQ36350540
An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control regionQ36534473
The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant regionQ36675781
NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiationQ36686647
Independent immunoglobulin class-switch events occurring in a single myeloma cell lineQ36887841
DNA rearrangement causes a high rate of spontaneous mutation at the immunoglobulin heavy-chain locus of a mouse myeloma cell lineQ36901225
Myeloma mutant with a novel 3' flanking region: loss of normal sequence and insertion of repetitive elements leads to decreased transcription but normal processing of the alpha heavy-chain gene productsQ36915080
Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targetingQ37476238
Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expressionQ37525753
Rate of somatic mutation in immunoglobulin production by mouse myeloma cellsQ37548685
Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporationQ37577496
Electroporation in biology: methods, applications, and instrumentationQ39569697
Activation of cellular oncogenes in hemopoietic cells by chromosome translocationQ39591625
The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cellsQ39638813
Linkage analysis using somatic cell hybridsQ39869143
V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancerQ40873078
Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.Q40875075
Characterization of immunoglobulin enhancer deletions in murine plasmacytomasQ41433504
Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma × T cell hybridsQ41434010
Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.Q41459613
DNA regions flanking the mouse Ig 3' alpha enhancer are differentially methylated and DNAase I hypersensitive during B cell differentiation.Q41570425
Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variantQ41582793
Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control regionQ41621028
Extinction of expression of the translocated myc gene in somatic cell hybrids between mouse myeloma and L-cellsQ43473653
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell lineQ43720366
Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cellsQ48079149
The mouse IgH 3'-enhancerQ48223460
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genesQ48397666
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain geneQ48397674
A class switch control region at the 3′ end of the immunoglobulin heavy chain locusQ59886033
5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strainsQ71520598
Lipopolysaccharide-dependent transactivation of the temporally regulated immunoglobulin heavy chain 3' enhancerQ71632758
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)6229-6238
P577publication date1995-12-01
P1433published inThe EMBO JournalQ1278554
P1476titleImmunoglobulin gene transcription ceases upon deletion of a distant enhancer
P478volume14

Reverse relations

cites work (P2860)
Q358508472,3,7,8-tetrachlorodibenzo-p-dioxin induces transcriptional activity of the human polymorphic hs1,2 enhancer of the 3'Igh regulatory region
Q41078837A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer
Q74729938Accessibility control of V(D)J recombination: lessons from gene targeting
Q40942682Catfish Oct2 binding affinity and functional preference for octamer motifs, and interaction with OBF-1.
Q33823918Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites
Q38490236Cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells
Q36404262Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.
Q35758815Comparison of Identical and Functional Igh Alleles Reveals a Nonessential Role for Eμ in Somatic Hypermutation and Class-Switch Recombination
Q37638286Concerted repression of an immunoglobulin heavy-chain enhancer, 3' alpha E(hs1,2)
Q73443168Context-dependent Pax-5 repression of a PU.1/NF-kappaB regulated reporter gene in B lineage cells
Q93339041Discovery platform for inhibitors of IgH gene enhancer activity
Q35310199Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching
Q43169305Elucidation of a downstream boundary of the 3' IgH regulatory region
Q35402437Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.
Q38209322Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region
Q41118585Evaluation of novel control elements by construction of eukaryotic expression vectors
Q38502702Expression of the (recombinant) endogenous immunoglobulin heavy-chain locus requires the intronic matrix attachment regions
Q41769247Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus
Q35144777Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination
Q35983657Hydrogen peroxide modulates immunoglobulin expression by targeting the 3'Igh regulatory region through an NFκB-dependent mechanism
Q48041909Identification of a homolog of the C alpha 3'/hs3 enhancer and of an allelic variant of the 3'IgH/hs1,2 enhancer downstream of the human immunoglobulin alpha 1 gene
Q74419737Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination
Q36826861Loss of an Igκ gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation
Q73066485Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes
Q73101481NFE, a new transcriptional activator that facilitates p50 and c-Rel-dependent IgH 3' enhancer activity
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Q71740203Physiological activation of the IgH 3' enhancer in B lineage cells is not blocked by Pax-5
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Q36573288Regulation of the replication of the murine immunoglobulin heavy chain gene locus: evaluation of the role of the 3' regulatory region
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Q34586354Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination
Q42633662Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription

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