Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching

scientific article

Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.243543
P8608Fatcat IDrelease_fylpwhwgrnajdh3jroz5qdsnna
P932PMC publication ID3190736
P698PubMed publication ID21685395

P2093author name stringAlexander V Emelyanov
Barbara K Birshtein
Zhongliang Ju
Rabih Hassan
Sabrina A Volpi
Sanjukta Chatterjee
P2860cites workThe interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cellsQ24292183
The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAPQ24630244
Mediator and cohesin connect gene expression and chromatin architectureQ24632695
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The protein CTCF is required for the enhancer blocking activity of vertebrate insulatorsQ28142800
The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cellsQ28237020
PTIP promotes chromatin changes critical for immunoglobulin class switch recombinationQ28585503
Cohesin mediates transcriptional insulation by CCCTC-binding factorQ29618130
Cohesins functionally associate with CTCF on mammalian chromosome armsQ29618753
Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer regionQ33591104
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytesQ33757410
A CTCF-independent role for cohesin in tissue-specific transcriptionQ33812535
Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sitesQ33823918
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrateQ33916866
The 3' IgH regulatory region: a complex structure in a search for a functionQ33957718
Elucidation of IgH intronic enhancer functions via germ-line deletionQ34063681
Mechanism and regulation of class switch recombinationQ34764888
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locusQ35914587
The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genesQ36403608
Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.Q36404262
Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashionQ36508536
NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiationQ36686647
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminaseQ37164427
NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombinationQ37164511
Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory regionQ37298924
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.Q37626538
Concerted repression of an immunoglobulin heavy-chain enhancer, 3' alpha E(hs1,2)Q37638286
The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cellsQ38337115
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencersQ38348243
Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes.Q39694573
Evidence for physical interaction between the immunoglobulin heavy chain variable region and the 3' regulatory regionQ40070959
Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.Q40875075
Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte developmentQ42140562
Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locusQ42799741
Role of OCA-B in 3'-IgH enhancer functionQ42802295
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE.Q46977803
Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.Q47765363
Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.Q50943562
Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.Q51065317
Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.Q51578905
DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.Q52222420
Regulation of 3' IgH enhancers by a common set of factors, including kappa B-binding proteins.Q52519188
NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells.Q53645307
In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse.Q54440283
A class switch control region at the 3′ end of the immunoglobulin heavy chain locusQ59886033
B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switchingQ70994054
Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombinationQ74419737
Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombinationQ82459169
P433issue33
P407language of work or nameEnglishQ1860
P304page(s)29303-29312
P577publication date2011-06-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleDynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching
P478volume286

Reverse relations

cites work (P2860)
Q578183413' enhancers hs3b/hs4 are dispensable for deregulation in mouse plasmacytomas with T(12;15) translocations
Q35242981An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex
Q40587292Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.
Q58581020Complex sex-biased antibody responses: Estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers
Q93339041Discovery platform for inhibitors of IgH gene enhancer activity
Q38209322Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region
Q41769247Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus
Q27001131IgH chain class switch recombination: mechanism and regulation
Q39468841Interaction between the immunoglobulin heavy chain 3' regulatory region and the IgH transcription unit during B cell differentiation
Q26782103Long-Range Regulation of V(D)J Recombination
Q35399209Stage-specific binding profiles of cohesin in resting and activated B lymphocytes suggest a role for cohesin in immunoglobulin class switching and maturation
Q37322210The cohesin complex regulates immunoglobulin class switch recombination.
Q41109057The role of CTCF binding sites in the 3' immunoglobulin heavy chain regulatory region
Q57639716and isoforms are both efficient to drive B cell differentiation

Search more.