CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation.

scientific article published on 08 August 2016

CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.11113
P932PMC publication ID5295435
P698PubMed publication ID27521216

P50authorYao-An ShenQ85313360
P2093author name stringYann-Jang Chen
Hui-Yen Chuang
Chia-Yu Wang
Wing-Yin Li
Chih-Hung Shu
Ching-Yin Ho
Wei-Hsin Chi
John Jeng-Jong Hwang
P2860cites workHyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell InvasionQ24608189
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
Prospective identification of tumorigenic breast cancer cellsQ24683474
Epithelial-mesenchymal transitions in development and diseaseQ27860630
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Identification of pancreatic cancer stem cellsQ28286997
Cancer stem cells in solid tumours: accumulating evidence and unresolved questionsQ28293535
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAsQ29615910
Association of reactive oxygen species levels and radioresistance in cancer stem cellsQ29617812
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinomaQ29620604
Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasiaQ80039753
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinomaQ33598586
Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burdenQ33628532
Prognostic significance of CD24 expression in gastric carcinomaQ33746798
Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinomaQ33793359
Serine phosphorylation of STATsQ33941422
Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder.Q34280864
Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomasQ34323867
Stat3 dimerization regulated by reversible acetylation of a single lysine residueQ34384817
Regulation of STAT-dependent pathways by growth factors and cytokines.Q34413932
Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancerQ34552074
Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinomaQ35157443
Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell linesQ35363169
CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival.Q35789342
Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguityQ36014411
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenanceQ36092560
Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancerQ36304018
Identification of ABCG2⁺ cells in nasopharyngeal carcinoma cellsQ36642849
CD44 and EpCAM: cancer-initiating cell markersQ37347302
CD24: from A to Z.Q37692167
How should we define STAT3 as an oncogene and as a potential target for therapy?Q38143961
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisQ38290076
JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cellsQ39130848
CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulationQ39512947
Identification of cancer stem-like CD44+ cells in human nasopharyngeal carcinoma cell lineQ39581105
CD24: a novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cellsQ39594837
Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.Q39619885
Bmi1 is essential in Twist1-induced epithelial–mesenchymal transitionQ39659307
Hyaluronan-CD44 Interactions in Cancer: Paradoxes and PossibilitiesQ39919533
Inhibition of malignant activities of nasopharyngeal carcinoma cells with high expression of CD44 by siRNA.Q40111316
Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell lineQ40144546
Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes.Q40418655
EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loopQ41122951
Characterization of seven newly established nasopharyngeal carcinoma cell linesQ41552112
Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinomaQ42481702
Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motilityQ42828844
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
Expression of CD24 in adenocarcinomas of the pancreas correlates with higher tumor grades.Q52943896
Roots and stems: stem cells in cancer.Q53348663
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
neoplastic stem cellsQ1638475
P304page(s)58351-58366
P577publication date2016-09-01
P1433published inOncotargetQ1573155
P1476titleCD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation
P478volume7

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cites work (P2860)
Q59136925BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits
Q92977554Cancer cell reprogramming: a promising therapy converting malignancy to benignity
Q57073625Cell-cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis
Q57068123Cells isolated from residual intracranial tumors after treatment express iPSC genes and possess neural lineage differentiation plasticity
Q37630359HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
Q55259421Identification of CD24 as a marker for tumorigenesis of melanoma.
Q55394876MicroRNA-328 inhibits migration and epithelial-mesenchymal transition by targeting CD44 in nasopharyngeal carcinoma cells.
Q37713683Ovarian cancer stem cells: still an elusive entity?
Q52927258Phosphoproteomic analysis reveals hyperactivation of mTOR/STAT3 and LCK/Calcineurin axes in pediatric early T-cell precursor ALL.

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