TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas

scientific article published on 06 May 2015

TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YGYNO.2015.04.039
P932PMC publication ID5303002
P698PubMed publication ID25958320

P50authorSusan Band HorwitzQ16866414
Kunle OdunsiQ38296739
P2093author name stringKevin H Eng
Gary L Goldberg
Brandon-Luke L Seagle
Monica Dandapani
Shohreh Shahabi
Chia-Ping Huang Yang
Oluwatosin Odunsi-Akanji
P2860cites workEpothilones and new analogues of the microtubule modulators in taxane-resistant diseaseQ57244875
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapyQ77932308
Prognostic Significance of p53 Mutation and p53 Overexpression in Advanced Epithelial Ovarian Cancer: A Gynecologic Oncology Group StudyQ79150763
GADD45 proteins: central players in tumorigenesisQ24608649
Integrated genomic analyses of ovarian carcinomaQ27860518
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Ixabepilone: a novel microtubule-stabilizing agent for the treatment of metastatic breast cancerQ28298312
Mutational landscape and significance across 12 major cancer typesQ28300353
New colorimetric cytotoxicity assay for anticancer-drug screeningQ29615418
Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53Q30538161
Various forms of mutant p53 confer sensitivity to cisplatin and doxorubicin in bladder cancer cellsQ33182188
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescenceQ34196515
Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line.Q34303662
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.Q34722347
TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma.Q34775855
Clinical relevance of gain-of-function mutations of p53 in high-grade serous ovarian carcinomaQ34965421
Critical evaluation of p53 as a prognostic marker in ovarian cancerQ35775409
Ixabepilone, first in a new class of antineoplastic agents: the natural epothilones and their analogues.Q37005090
Epothilones: clinical update and future directions.Q37160242
The consequence of oncomorphic TP53 mutations in ovarian cancerQ37225303
New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer TherapyQ38036571
Mutant p53 in cancer: new functions and therapeutic opportunitiesQ38197826
Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.Q38360135
ERα directly activated the MDR1 transcription to increase paclitaxel-resistance of ERα-positive breast cancer cells in vitro and in vivoQ39200467
Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian cancer cells.Q40536091
Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicityQ40794489
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.Q40851562
Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53.Q40977069
Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell deathQ41717170
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical studyQ44061889
Mechanisms of mutant p53 stabilization in cancerQ45002935
Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer.Q46496853
Medical device epidemiology and surveillance: patient safety is the bottom lineQ51319039
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).Q52196656
Mechanisms of Taxol-induced cell death are concentration dependentQ52531670
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
The Cancer Genome AtlasQ3979425
P1104number of pages6
P304page(s)159-164
P577publication date2015-05-06
P1433published inGynecologic OncologyQ5625182
P1476titleTP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas
P478volume138

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cites work (P2860)
Q33779691Antiangiogenesis and gene aberration-related therapy may improve overall survival in patients with concurrent KRAS and TP53 hotspot mutant cancer
Q37688456Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface
Q91526471Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers
Q49901846Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing
Q64115872Influence of p53 Isoform Expression on Survival in High-Grade Serous Ovarian Cancers
Q39233197Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician.
Q36369910Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations
Q50952562Phase II trial of albumin-bound paclitaxel and granulocyte macrophage colony-stimulating factor as an immune modulator in recurrent platinum resistant ovarian cancer
Q38741073Recently identified drug resistance biomarkers in ovarian cancer
Q35979091Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces
Q64937484TP53 mutations in epithelial ovarian cancer.
Q26768521Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy

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