New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy

scientific article published on 15 July 2012

New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1155/2012/170325
P932PMC publication ID3403320
P698PubMed publication ID22911014
P5875ResearchGate publication ID230714476

P2093author name stringDavid Murray
Bonnie Andrais
Razmik Mirzayans
April Scott
P2860cites workAtaxia-telangiectasia and cellular responses to DNA damage.Q40922688
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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasisQ24312492
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathwaysQ24321528
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Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATMQ28611443
Blinded by the Light: The Growing Complexity of p53Q29547590
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathwayQ42812297
Q&A: Cancer: clues from cell metabolismQ43045797
Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.Q43684832
Mammalian target of rapamycin (mTOR): pro- and anti-apoptoticQ43882655
Nuclear envelope-limited chromatin sheets are part of mitotic deathQ43933778
2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism.Q44480775
PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.Q44678852
2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivoQ44732835
Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis.Q44926431
Autophagy, senescence and tumor dormancy in cancer therapyQ44950633
Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152.Q46847084
Ultraviolet light exposure triggers nuclear accumulation of p21(WAF1) and accelerated senescence in human normal and nucleotide excision repair-deficient fibroblast strainsQ46982682
Aberrant p21WAF1-dependent growth arrest as the possible mechanism of abnormal resistance to ultraviolet light cytotoxicity in Li-Fraumeni syndrome fibroblast strains heterozygous for TP53 mutationsQ47684754
A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells.Q47738952
Radiosensitivity in ataxia telangiectasia fibroblasts is not associated with deregulated apoptosisQ47895763
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.Q48478195
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.Q50335767
Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio.Q52546877
p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.Q53554846
Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer.Q53620789
Single-cell analysis of p16(INK4a) and p21(WAF1) expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni Syndrome fibroblasts.Q54701406
Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73Q58073315
Wild-type human p53 activates the human epidermal growth factor receptor promoterQ72351836
Control of E2F activity by p21Waf1/Cip1Q73023858
At the end of the millennium, a view of the endQ73225990
Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1/waf1/sdi1) in DNA replication and transcriptionQ73615893
p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activationQ79405060
Optimization of halopemide for phospholipase D2 inhibitionQ79816958
p73 suppresses polyploidy and aneuploidy in the absence of functional p53Q80813940
Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cellsQ81419187
p53-based anti-cancer therapies: An empty promise?Q84911725
Restoration of p53 function leads to tumour regression in vivoQ29618727
Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosisQ31983511
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cellsQ32084034
Mutant p53 gain-of-function in cancerQ33687048
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activationQ33855418
Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressQ33997846
Phospholipase D-mTOR requirement for the Warburg effect in human cancer cellsQ34440418
TP53 mutations in nonsmall cell lung cancerQ34559185
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cellsQ34625589
Novel targets of Akt, p21(Cipl/WAF1), and MDM2.Q34759285
Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe.Q34956023
Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Q35001142
Two-phase dynamics of p53 in the DNA damage response.Q35022037
The p53-Mdm2 module and the ubiquitin system.Q35036580
Tumor cell senescence in cancer treatmentQ35143435
Targeting Aurora-2 kinase in cancer.Q35157030
Targeting PI3K-AKT pathway for cancer therapyQ35648847
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseasesQ35680797
Hallmarks of senescence in carcinogenesis and cancer therapyQ35743144
The p53 response to DNA damageQ35848498
PI3K/Akt/mTOR pathway as a target for cancer therapyQ36227186
Neosis--a paradigm of self-renewal in cancerQ36326465
The complexity of p53 stabilization and activationQ36443523
p53 as a target for anti-cancer drug development.Q36475676
p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agentsQ36605767
Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.Q36732919
Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-RasQ36745757
Cell fate decision mediated by p53 pulsesQ37262599
Dichloroacetate induces apoptosis in endometrial cancer cells.Q37328044
Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistantQ37354811
Mutant p53 mediates survival of breast cancer cellsQ37424034
Cellular Senescence - its role in cancer and the response to ionizing radiationQ37915652
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaksQ38609721
Mitochondrial regulation of cell death: mitochondria are essential for procaspase 3-p21 complex formation to resist Fas-mediated cell deathQ39446000
Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domainQ39575066
p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program.Q39582775
Time-dependently expressed markers and the characterization for premature senescence induced by ionizing radiation in MCF7.Q39685860
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cellsQ39730167
Apoptotic signalling in HeLa Hep2 cells following 5 Gy of cobalt-60 gamma radiation.Q39759574
Involvement of p21Waf1/Cip1 cleavage during roscovitine-induced apoptosis in non-small cell lung cancer cells.Q39767769
BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapyQ39815503
The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cellsQ39848059
Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cellsQ39875544
p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damageQ39892611
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiationQ39957013
Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell deathQ39981751
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.Q39983426
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiationQ39984345
Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cellsQ39992839
p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoterQ40022446
Suppression of TGF-beta signaling by phospholipase D.Q40046108
RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer modelQ40106656
Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D.Q40265316
Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cellsQ40291647
Phospholipase D couples survival and migration signals in stress response of human cancer cellsQ40295842
mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cellsQ40383681
Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells.Q40400655
CDK2 translational down-regulation during endothelial senescenceQ40415938
Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain.Q40474411
Induction of accelerated senescence by gamma radiation in human solid tumor-derived cell lines expressing wild-type TP53.Q40479643
Alternative phospholipase D/mTOR survival signal in human breast cancer cellsQ40484574
p21/CDKN1A mediates negative regulation of transcription by p53.Q40647697
Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecinQ40747055
Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.Q40788757
Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblastsQ40812808
Tumor-derived p53 mutant C174Y is a gain-of-function mutant which activates the fos promoter and enhances colony formationQ40852695
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectcancerQ12078
phosphoproteinQ423934
signal transductionQ828130
neoplasmQ1216998
transport proteinQ2111029
DNA-binding proteinQ2252764
DNA damageQ5205747
nuclear proteinQ16860021
neoplasm proteinQ66894191
P304page(s)170325
P577publication date2012-07-15
P1433published inJournal of Biomedicine and BiotechnologyQ15752146
P1476titleNew insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy
P478volume2012

Reverse relations

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