Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium

scientific article published on 03 January 2014

Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CB400759D
P932PMC publication ID3962707
P698PubMed publication ID24354286

P50authorTamara AllistonQ42088746
Jeremy O JonesQ78720330
P2093author name stringLeila Su
Dan Nguyen
Maya Otto-Duessel
Miaoling He
Minyoung Lim
Emily Chin
P2860cites workRegression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptorQ24319189
Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfacesQ24551024
From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cellsQ24682910
A surface on the androgen receptor that allosterically regulates coactivator bindingQ27648698
Cancer statistics, 2013Q27860762
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growthQ28116222
Molecular determinants of resistance to antiandrogen therapyQ28236889
Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activityQ28238939
Steroid receptor heterodimerization demonstrated in vitro and in vivoQ28571816
Increased survival with enzalutamide in prostate cancer after chemotherapyQ29617511
Small-molecule inhibitors of protein-protein interactions: progressing towards the dreamQ29617758
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancerQ30485336
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variantQ30495758
Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcriptionQ33292178
Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy.Q33770362
Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancerQ33823702
Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoidsQ33958788
Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatinQ33994331
Cell- and gene-specific regulation of primary target genes by the androgen receptorQ34005736
Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteinsQ34163692
Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptorQ34973238
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft modelQ35209369
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variantsQ35249697
Androgen receptor: a key molecule in the progression of prostate cancer to hormone independenceQ35645358
Androgen receptor cross-talk with cell signalling pathwaysQ35934837
Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signalQ36003940
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1αQ36926447
Target deconvolution strategies in drug discoveryQ36961595
Pathologic effects of testosterone deprivationQ36964257
Proteomic methods for drug target discoveryQ37087549
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistanceQ37145531
Non-competitive androgen receptor inhibition in vitro and in vivo.Q37182710
Structural basis of androgen receptor binding to selective androgen response elements.Q37414946
Castration-resistant prostate cancer: targeting androgen metabolic pathways in recurrent diseaseQ37469444
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell linesQ39250655
Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progressionQ39605639
Runx2 regulates survivin expression in prostate cancer cellsQ39769098
Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancerQ40105462
The androgen receptor: an overview.Q40734794
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.Q40812297
Target identification using drug affinity responsive target stability (DARTS)Q42959458
Effects of selective androgen receptor modulator (SARM) treatment in osteopenic female rats.Q43281529
Changes in bone mineral density, lean body mass and fat content as measured by dual energy x-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapyQ43980991
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stabilityQ45149773
Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression.Q46882539
The Androgen Receptor Gene Mutations DatabaseQ73943347
p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6Q78386054
A cellular conformation-based screen for androgen receptor inhibitorsQ81529840
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancerQ85054415
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)692-702
P577publication date2014-01-03
P1433published inACS Chemical BiologyQ165583
P1476titleLigand-independent and tissue-selective androgen receptor inhibition by pyrvinium
P478volume9

Reverse relations

cites work (P2860)
Q38711524Androgen inhibits key atherosclerotic processes by directly activating ADTRP transcription
Q38350089Are androgen receptor variants a substitute for the full-length receptor?
Q53126460Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions.
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Q35548750Drug affinity responsive target stability (DARTS) for small-molecule target identification
Q64253591Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain Inhibitor Pyrvinium
Q34365632Molecular pathways and targets in prostate cancer
Q60015421Molecules targeting the androgen receptor (AR) signaling axis beyond the AR-Ligand binding domain
Q34495028Recent advances in allosteric androgen receptor inhibitors for the potential treatment of castration-resistant prostate cancer.
Q34249190Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer
Q38698469Synthesis and evaluation of novel thiazole-based derivatives as selective inhibitors of DNA-binding domain of the androgen receptor.
Q89947575Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
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