Are androgen receptor variants a substitute for the full-length receptor?

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Are androgen receptor variants a substitute for the full-length receptor? is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1005325657
P356DOI10.1038/NRUROL.2015.13
P698PubMed publication ID25666893
P5875ResearchGate publication ID272193179

P2093author name stringDonald J Tindall
Ji Lu
Travis Van der Steen
P2860cites workNuclear receptor structure: implications for functionQ36669652
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer.Q36681101
Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expressionQ36807948
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growthQ36876865
An androgen receptor N-terminal domain antagonist for treating prostate cancer.Q36966859
Minireview: the intersection of steroid receptors with molecular chaperones: observations and questionsQ36971803
Posttranslational modification of the androgen receptor in prostate cancerQ37092022
Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors.Q37093536
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistanceQ37145531
Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factorsQ37488488
FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variantsQ37560428
Ligand-independent and tissue-selective androgen receptor inhibition by pyrviniumQ37656304
The cistrome and gene signature of androgen receptor splice variants in castration resistant prostate cancer cellsQ38965060
Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptorQ38971752
Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues.Q39020826
NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variantsQ39148465
The role of DAB2IP in androgen receptor activation during prostate cancer progressionQ39162930
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell linesQ39250655
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.Q39329100
AR-Q640X, a model to study the effects of constitutively active C-terminally truncated AR variants in prostate cancer cellsQ39390992
Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance.Q39429490
Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progressionQ39605639
Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer.Q39647282
The androgen receptor gene mutations database: 2012 update.Q39652410
Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line.Q39787201
Steroid hormone receptors in prostate cancer: a hard habit to break?Q39922512
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancerQ39954334
Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independenceQ40073673
A splicing variant of the androgen receptor detected in a metastatic prostate cancer exhibits exclusively cytoplasmic actions.Q40125649
A naturally derived small molecule disrupts ligand-dependent and ligand-independent androgen receptor signaling in human prostate cancer cellsQ42006737
Shortened isoforms of the androgen receptor are regulated by the cytoprotective heat-shock protein HSPB1 and the tumor-suppressive microRNA miR-1 in prostate cancer cellsQ44235399
Mechanisms of androgen-refractory prostate cancerQ45094999
Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progressionQ46470624
Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer.Q47383290
Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors.Q53170054
IL-6, IL-10 and HSP-90 expression in tissue microarrays from human prostate cancer assessed by computer-assisted image analysisQ79342871
Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancerQ94358725
Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survivalQ21091046
Androgen receptor variants occur frequently in castration resistant prostate cancer metastasesQ21558502
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptorQ24319189
AR-V7 and resistance to enzalutamide and abiraterone in prostate cancerQ27853062
Cancer statistics, 2014Q27861018
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growthQ28116222
Molecular determinants of resistance to antiandrogen therapyQ28236889
The development of androgen-independent prostate cancerQ29615650
Androgen receptor in prostate cancerQ29616454
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancerQ30485336
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variantQ30495758
AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progressionQ30513836
AR variant ARv567es induces carcinogenesis in a novel transgenic mouse model of prostate cancerQ30544584
TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer.Q30554439
Androgen receptor splice variants determine taxane sensitivity in prostate cancerQ30577613
ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell linesQ33593873
Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapyQ33688956
Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complexQ34007618
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptorQ34165500
Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancerQ34249190
The role of epithelial plasticity in prostate cancer dissemination and treatment resistanceQ34505037
Contribution of the androgen receptor to prostate cancer predisposition and progressionQ34708708
Constitutively active androgen receptor variants upregulate expression of mesenchymal markers in prostate cancer cellsQ34713218
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancerQ35150756
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variantsQ35249697
Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells.Q35372023
Alternatively spliced androgen receptor variantsQ35606969
ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.Q35763908
A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activitiesQ35990121
Mechanisms of the androgen receptor splicing in prostate cancer cellsQ36005683
Vav3 enhances androgen receptor splice variant activity and is critical for castration-resistant prostate cancer growth and survivalQ36454548
New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cellsQ36582853
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)137-144
P577publication date2015-02-10
P1433published inNature Reviews UrologyQ2079265
P1476titleAre androgen receptor variants a substitute for the full-length receptor?
P478volume12