Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells

scientific article published on 14 July 2010

Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.0902572
P932PMC publication ID3963465
P698PubMed publication ID20631314
P5875ResearchGate publication ID45188543

P50authorAndrew ZlozaQ61127982
P2093author name stringWei Li
Jason M Schenkel
Lena Al-Harthi
Srinivas D Narasipura
P2860cites workNeoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expressionQ39446786
CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV.Q39633119
Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformationQ41869389
The B cell antigen receptor regulates the transcriptional activator beta-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase-3.Q44049968
Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor.Q46010300
Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration.Q46870331
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathwaysQ47937413
Activation of the Wnt signaling pathway: a molecular mechanism for lithium actionQ48958687
Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cellsQ49212979
Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry.Q50916814
Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions.Q52001720
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin.Q52117017
Cytofluorometric Identification of Two Populations of Double Positive (CD4+,CD8+) T Lymphocytes in Human Peripheral BloodQ61928411
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survivalQ74286666
Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cellsQ80622205
Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xLQ81598302
Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathwayQ83059430
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaQ24336272
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cellsQ24651232
CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migrationQ24680875
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigrationQ30479330
Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.Q33785363
Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surfaceQ33843968
The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigensQ33928484
Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivoQ34486226
CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infectionQ34514930
Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesisQ35980019
Productive infection of neonatal CD8+ T lymphocytes by HIV-1.Q36400552
Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cellsQ36484014
Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteinsQ36487614
ICAT expression disrupts beta-catenin-TCF interactions and impairs survival of thymocytes and activated mature T cellsQ36916479
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)2013-2019
P577publication date2010-07-14
P1433published inJournal of ImmunologyQ3521441
P1476titleBeta-catenin signaling mediates CD4 expression on mature CD8+ T cells
P478volume185

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cites work (P2860)
Q28248395A human memory T cell subset with stem cell-like properties
Q50947267Canine CD4+CD8+ double positive T cells in peripheral blood have features of activated T cells.
Q34944392Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS
Q36805264Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.
Q41628988HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity
Q36387228Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner
Q90491406Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis
Q38605585Peripheral canine CD4(+)CD8(+) double-positive T cells - unique amongst others
Q38307464Review of lithium effects on immune cells
Q93176410Stress and immunosenescence: The role of telomerase
Q40434616T lymphocyte immunophenotypes in the cerebrospinal fluid of dogs with visceral leishmaniasis.
Q91555200Transcriptomic features of tumour-infiltrating CD4lowCD8high double positive αβ T cells in melanoma
Q36544112Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells

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