E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling

scientific article published on 30 January 2017

E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1621355114
P932PMC publication ID5320996
P698PubMed publication ID28137882

P2093author name stringTak W Mak
Kelsie L Thu
Yi Sheng
Andrew J Elia
Zhenyue Hao
Jillian Haight
Parameswaran Ramachandran
Carmen Dominguez-Brauer
Rahima Khatun
Lisa D Jones
Shakiba P Baniasadi
P2860cites workARF-BP1/Mule is a critical mediator of the ARF tumor suppressorQ24306428
Comprehensive molecular characterization of human colon and rectal cancerQ24630415
Wnt signaling in breast cancer: have we come full circle?Q24801811
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferationQ28280330
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Crypt stem cells as the cells-of-origin of intestinal cancerQ28304418
Proximal events in Wnt signal transductionQ29616162
Paneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsQ29616197
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Wnt signalling regulates adult hippocampal neurogenesisQ29619688
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p53 mutations in colorectal cancerQ33818791
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligaseQ35275756
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.Q35679564
Self-renewal and cancer of the gut: two sides of a coin.Q36080124
Wnt signaling in the intestinal epithelium: from endoderm to cancerQ36099900
Recurrent R-spondin fusions in colon cancerQ36949683
Molecular pathways involved in colorectal cancer: implications for disease behavior and preventionQ37139174
The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cellsQ37426747
Wnt signaling in normal and malignant hematopoiesisQ38078915
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal DegradationQ40071670
Return to quiescence of mouse neural stem cells by degradation of a proactivation protein.Q40389833
Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lostQ42242504
Genomic Correlates of Immune-Cell Infiltrates in Colorectal CarcinomaQ42375951
Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathwayQ47069565
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.Q52118607
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.Q52423411
Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumorQ57964092
P4510describes a project that useslimmaQ112236343
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)E1148-E1157
P577publication date2017-01-30
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleE3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling
P478volume114

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cites work (P2860)
Q55411157Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.
Q58693481HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development
Q90352927HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53
Q47927828Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis
Q48257092Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.
Q92195187NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
Q57106057Targeting the turnover of oncoproteins as a new avenue for therapeutics development in castration-resistant prostate cancer
Q92446155The Role of Ubiquitination in Regulating Embryonic Stem Cell Maintenance and Cancer Development
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Q58636039The frequency of promoter DNA hypermethylation is decreased in colorectal neoplasms of familial adenomatous polyposis
Q88985377USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization
Q102053996WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID

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