Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation

scientific article published on February 2013

Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S11239-012-0812-9
P932PMC publication ID3969264
P698PubMed publication ID23054462
P5875ResearchGate publication ID232231103

P2093author name stringHeidi E Hamm
John H Cleator
Qingxia Chen
Michael Holinstat
Dana Blakemore
Nancy E Colowick
Willie J Hudson
P2860cites workA new role for P-selectin in shear-induced platelet aggregationQ73108662
Pathophysiology of platelet thrombin receptorsQ73447376
Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathwayQ79411445
Greater inhibitory effects of bivalirudin compared with unfractionated heparin plus eptifibitide on thrombin-induced platelet activationQ79917817
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotectiveQ24293646
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationQ28118463
Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trialQ28210574
Protease-activated receptors in cardiovascular diseasesQ28261926
Bivalirudin during primary PCI in acute myocardial infarctionQ28281179
Thrombin signalling and protease-activated receptorsQ29619601
Rap1b is required for normal platelet function and hemostasis in miceQ33778323
Antithrombotic effects of thrombin-induced activation of endogenous protein C in primatesQ33905952
Thrombin-receptor antagonist vorapaxar in acute coronary syndromesQ34231934
New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biologyQ34262824
Vorapaxar in the secondary prevention of atherothrombotic eventsQ34263311
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activationQ34560212
Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary interventionQ34906975
The evolving role of direct thrombin inhibitors in acute coronary syndromesQ35088077
The adhesion molecule P-selectin and cardiovascular diseaseQ35601863
P-selectin in arterial thrombosisQ35965541
Protease-activated receptors in hemostasis, thrombosis and vascular biologyQ36230881
G-protein-coupled receptors as signaling targets for antiplatelet therapyQ37331201
Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate.Q37786695
Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosisQ40310781
Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphatesQ42265142
Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: implications for coronary interventionQ44159298
Diabetic patients without vascular complications display enhanced basal platelet activation and decreased antioxidant statusQ44816746
Synergistic inhibition of platelet aggregation by fibrinogen-related peptidesQ44970734
Regulation of PAR-1 in patients undergoing percutaneous coronary intervention: effects of unfractionated heparin and bivalirudin.Q45997448
Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II studyQ46088369
Platelet P-selectin plays an important role in arterial thrombogenesis by forming large stable platelet-leukocyte aggregatesQ46443116
Safety and efficacy of bivalirudin monotherapy in patients with diabetes mellitus and acute coronary syndromes: a report from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trialQ46627427
Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudinQ46684149
Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitorQ47295608
The thrombomodulin-protein C system is essential for the maintenance of pregnancy.Q52549296
Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1.Q53434074
Abciximab and heparin versus bivalirudin for non-ST-elevation myocardial infarction.Q55055193
Prognostic Value of a High On-Clopidogrel Treatment Platelet Reactivity in Bivalirudin Versus Abciximab Treated Non–ST-Segment Elevation Myocardial Infarction PatientsQ60195494
Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometryQ68160190
P433issue2
P304page(s)209-222
P577publication date2013-02-01
P1433published inJournal of Thrombosis and ThrombolysisQ15766541
P1476titleDichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation
P478volume35

Reverse relations

cites work (P2860)
Q92242416Enhanced potency of prasugrel on protease-activated receptors following bivalirudin treatment for PCI as compared to clopidogrel
Q34186272Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects