Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates

scientific article published on 29 May 2009

Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/MOL.109.056622
P932PMC publication ID2713123
P698PubMed publication ID19483102
P5875ResearchGate publication ID26254009

P2093author name stringH Alex Brown
Stephen B Milne
Heidi E Hamm
Anita M Preininger
Michael Holinstat
W James Hudson
P2860cites workBiphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in plateletsQ73811661
Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathwayQ79411445
PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axisQ79782511
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in plateletsQ80730894
Analysis of intact phosphoinositides in biological samplesQ83189880
Atherosclerosis — An Inflammatory DiseaseQ26776972
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationQ28118463
The stratification of platelet reactivity and activation in patients with stable coronary artery disease on aspirin therapyQ28167699
Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase DQ28245266
Direct thrombin inhibitorsQ28271181
PI 3-kinase p110beta: a new target for antithrombotic therapyQ28588127
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering CommitteeQ29620666
Rap1b is required for normal platelet function and hemostasis in miceQ33778323
Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assayQ33905722
Thrombin and platelet activationQ34229835
Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphateQ34466007
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activationQ34560212
Platelets in atherothrombosisQ34986345
Ischemic heart disease and platelet aggregation. The Caerphilly Collaborative Heart Disease StudyQ35009072
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2Q35632195
The pathogenesis of coronary artery disease and the acute coronary syndromes (1).Q36728740
CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in plateletsQ36843696
Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositidesQ37239318
Sequential regulation of the small GTPase Rap1 in human plateletsQ39450674
Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signalingQ40398965
A targeted mass spectrometric analysis of phosphatidylinositol phosphate speciesQ40421655
ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activityQ41508317
Lipidomics: an analysis of cellular lipids by ESI-MS.Q42498340
Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphateQ42798203
Measurement of GTP-bound Ras-like GTPases by activation-specific probesQ43635844
Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.Q43740234
Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromesQ44272454
Akt Activation in Platelets Depends on Gi Signaling PathwaysQ44659684
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.Q46674143
Rho and Rho-kinase Mediate Thrombin-induced Phosphatidylinositol 4-Phosphate 5-Kinase Trafficking in PlateletsQ57372258
Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated plateletsQ67697815
Thrombin stimulates the production of a novel polyphosphoinositide in human plateletsQ68449002
Modulation of rat brain cytosolic phosphatidate phosphohydrolase: effect of cationic amphiphilic drugs and divalent cationsQ70173369
Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human plateletsQ72033892
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase DQ72135980
P433issue2
P304page(s)301-313
P577publication date2009-05-29
P1433published inMolecular PharmacologyQ1943386
P1476titleIrreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates
P478volume76

Reverse relations

cites work (P2860)
Q37721192Akt signaling in platelets and thrombosis
Q37671483Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation
Q41884542Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.
Q42082080Impaired feedback regulation of the receptor activity and the myofilament Ca2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage
Q36387226Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation
Q51615143Mathematical model of PAR1-mediated activation of human platelets.
Q46681431Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation
Q89169483Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases
Q37807924Platelet receptor signaling in thrombus formation
Q90672234Protease-Activated Receptor 1 as Therapeutic Target in Breast, Lung, and Ovarian Cancer: Pepducin Approach
Q36717080Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets
Q34560219Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis
Q35785016Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation
Q34342288The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3‐kinase pathway in maintaining thrombin‐induced platelet aggregation

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