Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.

scientific article

Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M104442200
P698PubMed publication ID11560922

P50authorStefan OffermannsQ2337253
Marie-Pierre GratacapQ55665033
P2093author name stringNieswandt B
Payrastre B
P2860cites workA novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to RhoQ22008793
Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assemblyQ57899443
Identification of the platelet ADP receptor targeted by antithrombotic drugsQ24290845
G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human plateletsQ24336496
Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinaseQ24672645
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to RhoQ28138634
Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscleQ28143022
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13Q28274727
Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1Q28346098
Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse plateletsQ28587227
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
Small GTPase Rho regulates thrombin-induced platelet aggregationQ31856290
Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape changeQ33178933
Rho Family GTPases Bind to Phosphoinositide KinasesQ33292549
Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets.Q33503577
Signaling to Rho GTPasesQ33783547
The role of Rho in G protein-coupled receptor signal transductionQ33932175
Signaling networks linking integrins and rho family GTPases.Q33984512
Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiencyQ35076168
Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinaseQ36058741
RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolismQ36326264
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.Q37380112
Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.Q40387432
N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phosphoinositide 3-kinasesQ40874510
Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.Q40890101
Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreadingQ40918517
Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.Q40978901
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalphaQ41014721
25 Identification of receptor-activated G proteins with photoreactive GTP analog, α-32PGTP azidoanilideQ41703896
The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphateQ41750994
Defective platelet activation in G alpha(q)-deficient mice.Q42547684
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cellsQ42796987
G protein betagamma subunits induce stress fiber formation and focal adhesion assembly in a Rho-dependent manner in HeLa cellsQ42806541
G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assemblyQ42823407
Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreadingQ42833721
G-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phosphate 5-kinase I alpha by a Rac- and Rho-dependent pathwayQ43657461
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cellsQ46524862
Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction.Q52970621
Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation.Q52978723
Identification of receptor-activated G proteins: selective immunoprecipitation of photolabeled G-protein alpha subunits.Q53019635
Rho GTPases and their effector proteinsQ56690400
P433issue51
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)47906-47913
P577publication date2001-09-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleDifferential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides
P478volume276

Reverse relations

cites work (P2860)
Q448795378-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinase
Q40606405Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.
Q46317385Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.
Q64105706Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis
Q43788419Can the antiplatelet effects of cangrelor be reliably studied in mice under in vivo and in vitro conditions using flow cytometry?
Q24529910Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF
Q44256161Characterization of the expression of PDZ-RhoGEF, LARG and G(alpha)12/G(alpha)13 proteins in the murine nervous system.
Q42676743Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.
Q64929172Cyclic nucleotide-dependent inhibitory signaling interweaves with activating pathways to determine platelet responses.
Q24295209Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5
Q33644883Differential phosphorylation of myosin light chain (Thr)18 and (Ser)19 and functional implications in platelets
Q37189926Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor: independent modulation of TPalpha signaling by prostacyclin and nitric oxide.
Q34130876G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells
Q24338356IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization
Q46496972Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics
Q42265142Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates
Q36893688Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation
Q34273486Lysophosphatidic acid in atherosclerotic diseases
Q28217479Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets
Q37964007Novel roles of cAMP/cGMP-dependent signaling in platelets.
Q36322315Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors
Q35568308Pasteurella multocida toxin as a tool for studying Gq signal transduction
Q36716517Phospholipase D signaling: orchestration by PIP2 and small GTPases
Q37725138Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family?
Q40694330Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation
Q46428451Rac1 is essential for phospholipase C-gamma2 activation in platelets
Q30476950Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.
Q30497856Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque
Q35683204Rap1-Rac1 circuits potentiate platelet activation
Q39086987Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets.
Q35849289Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets.
Q27025414Regulation of platelet plug formation by phosphoinositide metabolism
Q34764253Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4-phosphate
Q38057431Rho GTPases in platelet function
Q30436883RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets
Q43878513RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.
Q30409434RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation
Q35785016Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation
Q96022581Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR
Q36542078Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.
Q42116882The relative role of PLCbeta and PI3Kgamma in platelet activation
Q34021632Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho.
Q45028075Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation
Q24338392WNT-3a modulates platelet function by regulating small GTPase activity
Q38364180cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions

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