| scholarly article | Q13442814 |
| P2093 | author name string | Satya P. Kunapuli | |
| Soochong Kim | |||
| Jianguo Jin | |||
| P2860 | cites work | Journal of Pharmacology and Experimental Therapeutics | Q1500272 |
| AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas | Q24294176 | ||
| Mechanism of activation of protein kinase B by insulin and IGF-1 | Q24309528 | ||
| G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets | Q24336496 | ||
| Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation | Q28193702 | ||
| Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP | Q28215252 | ||
| Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI | Q28217312 | ||
| Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel | Q28370733 | ||
| Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site | Q28373472 | ||
| Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets | Q28609210 | ||
| Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | Q28646376 | ||
| The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase | Q29618387 | ||
| Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction | Q29618388 | ||
| Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily | Q30844287 | ||
| Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist | Q31882653 | ||
| Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. | Q33869038 | ||
| Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice | Q33903557 | ||
| Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate | Q34466007 | ||
| Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation | Q36166958 | ||
| Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase | Q37429675 | ||
| Activated Gαq Inhibits p110α Phosphatidylinositol 3-Kinase and Akt | Q40653974 | ||
| Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation | Q40657196 | ||
| Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits | Q40855288 | ||
| Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway | Q40986827 | ||
| Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function | Q41732034 | ||
| Defective platelet activation in G alpha(q)-deficient mice. | Q42547684 | ||
| Resistance to thromboembolism in PI3Kgamma-deficient mice. | Q43711871 | ||
| Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells. | Q43789257 | ||
| Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin | Q43918522 | ||
| Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling | Q43977694 | ||
| The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation | Q44225925 | ||
| Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. | Q47828172 | ||
| A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region | Q48205638 | ||
| Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. | Q54077482 | ||
| PKB Inhibition Prevents the Stimulatory Effect of Insulin on Glucose Transport and Protein Translocation but Not the Antilipolytic Effect in Rat Adipocytes | Q59466712 | ||
| Platelet-Derived Growth Factor-BB and Thrombin Activate Phosphoinositide 3-Kinase and Protein Kinase B: Role in Mediating Airway Smooth Muscle Proliferation | Q60129323 | ||
| Differential interaction of beta 1- and beta 3-adrenergic receptors with Gi in rat adipocytes | Q72771579 | ||
| Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms | Q73144400 | ||
| cAMP stimulates protein kinase B in a Wortmannin-insensitive manner | Q73456592 | ||
| Phosphatidylinositol 3-kinase activity regulates alpha -thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity | Q73631069 | ||
| G-Protein-coupled receptors and Fcgamma-receptors mediate activation of Akt/protein kinase B in human phagocytes | Q73824880 | ||
| Dual regulation of platelet protein kinase B | Q73939124 | ||
| 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth | Q74217711 | ||
| Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy | Q77928203 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| biochemistry | Q7094 | ||
| P304 | page(s) | 4186-4195 | |
| P577 | publication date | 2003-11-17 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Akt activation in platelets depends on Gi signaling pathways | |
| Akt Activation in Platelets Depends on Gi Signaling Pathways | |||
| P478 | volume | 279 |
| Q34249757 | A G(i) -independent mechanism mediating Akt phosphorylation in platelets |
| Q34071537 | A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin |
| Q52760854 | ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets. |
| Q37721192 | Akt signaling in platelets and thrombosis |
| Q35483767 | An important role for Akt3 in platelet activation and thrombosis |
| Q28588935 | An important role of the SRC family kinase Lyn in stimulating platelet granule secretion |
| Q42822978 | Antagonism of P2Y12reduces physiological thromboxane levels |
| Q39898489 | Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages |
| Q92854031 | Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells |
| Q34537021 | Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets |
| Q35647810 | Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors |
| Q37322052 | Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis |
| Q24618777 | Central role of the P2Y12 receptor in platelet activation |
| Q36464966 | Characterization of a new peptide agonist of the protease-activated receptor-1. |
| Q61810525 | Characterization of the distinct mechanism of agonist-induced canine platelet activation |
| Q37127241 | Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production. |
| Q36140286 | Circulating primers enhance platelet function and induce resistance to antiplatelet therapy. |
| Q28477535 | Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis |
| Q34580117 | Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race |
| Q34765520 | Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia |
| Q47565331 | Cryopreserved platelets demonstrate reduced activation responses and impaired signaling after agonist stimulation |
| Q34718342 | Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets. |
| Q58593716 | Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y receptor |
| Q36947785 | Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets |
| Q46849080 | Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity. |
| Q41809741 | Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets. |
| Q35809098 | Emerging roles for P2X1 receptors in platelet activation |
| Q21262034 | Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue |
| Q39443930 | Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function |
| Q92402178 | GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets |
| Q33396353 | Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation |
| Q34802394 | Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets |
| Q33288229 | Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation |
| Q36053009 | IRS-1 and vascular complications in diabetes mellitus |
| Q35039102 | Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice |
| Q30528247 | Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12. |
| Q42007763 | Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid |
| Q39366558 | Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes |
| Q64099277 | Inhibitory Effects of Ginsenoside Ro on Clot Retraction through Suppressing PI3K/Akt Signaling Pathway in Human Platelets |
| Q36447899 | Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform |
| Q42150686 | Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks |
| Q37509443 | Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor |
| Q42265142 | Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates |
| Q38326898 | Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation |
| Q42087887 | Mechanism of activation and functional role of protein kinase Ceta in human platelets |
| Q34169728 | Mutational analysis of residues important for ligand interaction with the human P2Y(12) receptor |
| Q46247864 | Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI. |
| Q54472611 | P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. |
| Q37828158 | P2Y12 receptor in platelet activation |
| Q38051192 | P2Y12 receptor: platelet thrombus formation and medical interventions. |
| Q28264649 | P2Y12 receptors: structure and function |
| Q54389473 | PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses. |
| Q37982455 | Platelet signaling-a primer. |
| Q40693554 | Platelet tissue factor synthesis in type 2 diabetic patients is resistant to inhibition by insulin |
| Q42324464 | Platelets and atherogenesis: Platelet anti-aggregation activity and endothelial protection from tomatoes (Solanum lycopersicum L.). |
| Q35604075 | Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction |
| Q51049601 | Preserved thrombin-inducible platelet activation in thienopyridine-treated patients. |
| Q41808295 | Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets. |
| Q35165343 | Protein kinase Cδ mediates the activation of protein kinase D2 in platelets |
| Q33420627 | RASA3 is a critical inhibitor of RAP1-dependent platelet activation |
| Q30498047 | RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury |
| Q58701013 | RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists |
| Q24305005 | Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions |
| Q33280659 | Regulatory network of inflammation downstream of proteinase-activated receptors |
| Q30436883 | RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets |
| Q51507695 | Role of P2Y12 Receptor in Thrombosis. |
| Q33495925 | Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets |
| Q43074653 | Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways |
| Q42095285 | S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses |
| Q36245561 | SDF-1α/CXCR4 Signaling in Lipid Rafts Induces Platelet Aggregation via PI3 Kinase-Dependent Akt Phosphorylation. |
| Q90320770 | Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice |
| Q64117085 | Signaling Pathways of Receptors Involved in Platelet Activation and Shedding of These Receptors in Stored Platelets |
| Q36290218 | The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling |
| Q24312716 | The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine |
| Q38213187 | The role of P2Y₁₂ receptor and activated platelets during inflammation |
| Q34342288 | The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3‐kinase pathway in maintaining thrombin‐induced platelet aggregation |
| Q35989423 | Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A. |
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