| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M507057200 |
| P8608 | Fatcat ID | release_g33kulivrfh2bktwkotlfsjzga |
| P698 | PubMed publication ID | 16009706 |
| P50 | author | John K Buolamwini | Q86908203 |
| Peter J. Houghton | Q112045947 | ||
| P2093 | author name string | Christopher L Morton | |
| Glen S Germain | |||
| Kuntebommanahalli N Thimmaiah | |||
| John B Easton | |||
| Shantaram Kamath | |||
| P2860 | cites work | Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 |
| Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex | Q24295120 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. | Q24514761 | ||
| Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA | Q24568308 | ||
| Signalling through phosphoinositide 3-kinases: the lipids take centre stage | Q28141934 | ||
| Development and validation of a genetic algorithm for flexible docking | Q28236574 | ||
| Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation | Q28616026 | ||
| Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B | Q28638147 | ||
| Oncogenes and signal transduction | Q29547804 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| The phosphatidylinositol 3-Kinase AKT pathway in human cancer | Q29547860 | ||
| The TOR pathway: a target for cancer therapy | Q29614242 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 | Q29617416 | ||
| Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains | Q30175992 | ||
| Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design | Q30840946 | ||
| 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth | Q32020545 | ||
| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 | ||
| The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. | Q33783562 | ||
| Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. | Q33869038 | ||
| AKT plays a central role in tumorigenesis | Q33944165 | ||
| Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. | Q34330731 | ||
| Identification of TOR signaling complexes: more TORC for the cell growth engine | Q34952903 | ||
| Activation of the PI3K/Akt pathway and chemotherapeutic resistance | Q35046899 | ||
| Tor signalling in bugs, brain and brawn | Q35058522 | ||
| Targeting the PI3K-Akt pathway in human cancer: rationale and promise | Q35571372 | ||
| Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways | Q36564768 | ||
| Role of PI 3-kinase in mitogenesis | Q40387810 | ||
| Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors | Q40509516 | ||
| Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition | Q40593281 | ||
| Phosphatidylinositol 3-kinase | Q40702617 | ||
| Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? | Q40859203 | ||
| Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells | Q41485226 | ||
| Tautomerism of 2-azidoadenine nucleotides Effects on enzyme kinetics and photoaffinity labeling | Q42247052 | ||
| Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. | Q42991716 | ||
| Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. | Q44293983 | ||
| A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells | Q44714283 | ||
| Structure-based optimization of novel azepane derivatives as PKB inhibitors | Q44784861 | ||
| Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells | Q54262162 | ||
| High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity | Q57986498 | ||
| Amplification of 19q13.1–q13.2 sequences in ovarian cancer | Q58321636 | ||
| P433 | issue | 36 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 31924-31935 | |
| P577 | publication date | 2005-07-11 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling | |
| P478 | volume | 280 |
| Q39545042 | 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells |
| Q28472406 | A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling |
| Q34165508 | A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. |
| Q42326649 | ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β. |
| Q39545367 | Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis |
| Q33968347 | Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive. |
| Q38764730 | Akt isoform-dependent regulation of ATP-Binding cassette A1 expression by apolipoprotein E. |
| Q34936302 | Akt-induced phosphorylation of N-CoR at serine 1450 contributes to its misfolded conformational dependent loss (MCDL) in acute myeloid leukemia of the M5 subtype. |
| Q35091346 | Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism. |
| Q42474052 | Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation |
| Q41520547 | Akt/PKB controls the activity-dependent bulk endocytosis of synaptic vesicles |
| Q34412602 | Annexin 2 Regulates Endothelial Morphogenesis by Controlling AKT Activation and Junctional Integrity |
| Q34259118 | Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species |
| Q34147157 | Autophagy-regulating small molecules and their therapeutic applications |
| Q37478631 | CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells |
| Q39963624 | CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation |
| Q34705415 | Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis. |
| Q28477480 | Corticotropin releasing factor-induced CREB activation in striatal neurons occurs via a novel Gβγ signaling pathway |
| Q41478365 | Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus |
| Q33893744 | Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex |
| Q40277135 | Evaluation of potential mechanisms underlying genotype-phenotype correlations in multiple endocrine neoplasia type 2. |
| Q36267774 | FoxG1 promotes the survival of postmitotic neurons |
| Q47224869 | Glucose Uptake in the Human Pathogen Schistosoma mansoni Is Regulated Through Akt/Protein Kinase B Signaling |
| Q42373534 | Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis |
| Q36807494 | Inhibition of Akt pathways in the treatment of prostate cancer |
| Q34273718 | Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain |
| Q39612821 | Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract |
| Q34597522 | Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation. |
| Q42265142 | Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates |
| Q36973429 | Mechanical stimuli of skeletal muscle: implications on mTOR/p70s6k and protein synthesis. |
| Q35014924 | Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways |
| Q60348517 | Metal-free formal synthesis of phenoxazine |
| Q36683880 | Nuclear receptors and the Warburg effect in cancer |
| Q43195965 | Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation |
| Q55378794 | PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs. |
| Q42256993 | PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells |
| Q39610261 | Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells |
| Q39826959 | Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation |
| Q42572788 | Phosphorylation of ATXN1 at Ser776 in the cerebellum |
| Q38132630 | Prevention of carcinogenesis and development of gastric and colon cancers by 2-aminophenoxazine-3-one (Phx-3): direct and indirect anti-cancer activity of Phx-3 |
| Q36277174 | Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner |
| Q36959988 | Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages |
| Q35029064 | Relationships between Cytokine Profiles and Signaling Pathways (IκB Kinase and p38 MAPK) in Parainfluenza Virus-Infected Lung Fibroblasts |
| Q33525520 | The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas |
| Q34993322 | The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors |
| Q34785896 | Thyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes |
| Q50232295 | Ultrasound promoted synthesis of Nile Blue derivatives |
| Q33913340 | WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death |
| Q34349271 | YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets. |
| Q28268516 | mTOR and cancer therapy |
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