Heparanase promotes radiation resistance of cervical cancer by upregulating hypoxia inducible factor 1.

scientific article published on February 2017

Heparanase promotes radiation resistance of cervical cancer by upregulating hypoxia inducible factor 1. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID5336498
P698PubMed publication ID28337373

P2093author name stringJianping Li
Ying Zhang
Mei Shi
Jing Hu
Xin Meng
Lichun Wei
Yunzhi Dang
P2860cites workUnexpected new roles for heparanase in Type 1 diabetes and immune gene regulationQ27009264
Involvement of heparanase in atherosclerosis and other vessel wall pathologiesQ27025052
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Q27861047
Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasisQ28138868
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasmQ28343944
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy responseQ30573416
Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKLQ34267974
Role of heparanase in radiation-enhanced invasiveness of pancreatic carcinomaQ34762351
The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammationQ35848243
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vesselsQ35916654
Significance of heparanase in cancer and inflammationQ36101233
The potential of heparanase as a therapeutic target in cancerQ36452903
A critical review of patient-rated quality of life studies of long-term survivors of cervical cancerQ36485050
Heparanase: one molecule with multiple functions in cancer progressionQ37228578
Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.Q38052537
Radical hysterectomy with pelvic lymph node dissection for treatment of cervical cancer: a clinical review of 954 casesQ39474409
Heparanase promotes bone destruction and invasiveness in prostate cancerQ39981062
Tumor suppressor p53 regulates heparanase gene expressionQ40317250
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapyQ41903043
High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.Q43487753
Radical hysterectomy for invasive cervical cancer. A 25-year prospective experience with the Miami techniqueQ45008532
Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group studyQ45271357
Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates.Q50769115
RTOG 0417: efficacy of bevacizumab in combination with definitive radiation therapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma.Q53098455
Heparanase as mediator of angiogenesis: mode of actionQ74101720
A phase III randomized trial of postoperative pelvic irradiation in Stage IB cervical carcinoma with poor prognostic features: follow-up of a gynecologic oncology group studyQ82326945
P433issue2
P921main subjectcervix uterine cancerQ160105
hypoxiaQ105688
P304page(s)234-244
P577publication date2017-02-01
P1433published inAmerican Journal of Cancer ResearchQ17511667
P1476titleHeparanase promotes radiation resistance of cervical cancer by upregulating hypoxia inducible factor 1.
P478volume7

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cites work (P2860)
Q58585910Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity
Q59799492Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury
Q58616091Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway

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