The new normal: immunomodulatory agents against sepsis immune suppression

scientific article published on 30 January 2014

The new normal: immunomodulatory agents against sepsis immune suppression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLMED.2014.01.002
P932PMC publication ID3976785
P698PubMed publication ID24485901

P50authorAlfred AyalaQ55314071
Richard S HotchkissQ90459818
P2093author name stringJacqueline Unsinger
Noelle A Hutchins
P2860cites workDefective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiencyQ22008480
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B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patientsQ33753374
Clinical aspects: from systemic inflammation to 'immunoparalysis'.Q33801971
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Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survivalQ34017334
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.Q34039180
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.Q34120958
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PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsisQ34605998
Sepsis definitions: time for changeQ34649118
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Role of IL-15 in Sepsis-Induced Skeletal Muscle Atrophy and ProteolysisQ36512051
B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.Q36729527
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Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsisQ36997987
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Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.Q37238322
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PD-L1 blockade attenuated sepsis-induced liver injury in a mouse cecal ligation and puncture model.Q37351521
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Neutrophil paralysis in sepsisQ37780438
Harnessing the biology of IL-7 for therapeutic applicationQ37867487
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The function of neutrophils in sepsisQ37994057
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B7 family checkpoint regulators in immune regulation and diseaseQ38129635
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trialQ38316900
Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.Q38483410
Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteriaQ39855993
Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes.Q40684512
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndromeQ41155671
Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130.Q41663817
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunctionQ41897433
Dose-dependent effect of anti-CTLA-4 on survival in sepsisQ41976084
The sepsis seesaw: tilting toward immunosuppressionQ42035078
Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsisQ42229245
Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathwayQ43064735
Decreased T-cell repertoire diversity in sepsis: a preliminary studyQ43514997
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Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacityQ44569265
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyteQ45018156
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TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapyQ46421735
Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient miceQ48648759
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.Q52909875
Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patientsQ56906281
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunctionQ57773627
IL-7 Restores Lymphocyte Functions in Septic PatientsQ60547571
Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shockQ60547604
p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study GroupQ73343490
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humansQ73896312
Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patientsQ77754550
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic miceQ77788085
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsisQ77855901
Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsisQ78109886
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathwaysQ81621957
Sepsis: calming the cytokine stormQ84135047
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsisQ84255932
P433issue4
P921main subjectsepsisQ183134
P304page(s)224-233
P577publication date2014-01-30
P1433published inTrends in Molecular MedicineQ15265842
P1476titleThe new normal: immunomodulatory agents against sepsis immune suppression
P478volume20

Reverse relations

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