scholarly article | Q13442814 |
P50 | author | Alfred Ayala | Q55314071 |
Richard S Hotchkiss | Q90459818 | ||
P2093 | author name string | Jacqueline Unsinger | |
Noelle A Hutchins | |||
P2860 | cites work | Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency | Q22008480 |
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer | Q24633070 | ||
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation | Q24675931 | ||
Molecular mechanisms of T cell co-stimulation and co-inhibition | Q26864888 | ||
Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques | Q27346577 | ||
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care | Q27860820 | ||
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer | Q27860857 | ||
Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution | Q28251498 | ||
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 | Q28589743 | ||
The epidemiology of sepsis in the United States from 1979 through 2000 | Q29547760 | ||
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression | Q29618956 | ||
The pathophysiology and treatment of sepsis | Q29619103 | ||
Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy | Q33597681 | ||
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival | Q33614042 | ||
Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help. | Q33638464 | ||
B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients | Q33753374 | ||
Clinical aspects: from systemic inflammation to 'immunoparalysis'. | Q33801971 | ||
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy | Q33828888 | ||
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza | Q33875118 | ||
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine | Q33950150 | ||
Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival | Q34017334 | ||
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. | Q34039180 | ||
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. | Q34120958 | ||
IL-7 in human health and disease | Q34260682 | ||
Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model | Q34420239 | ||
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity | Q34554995 | ||
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis | Q34605998 | ||
Sepsis definitions: time for change | Q34649118 | ||
Altered CD8(+) T-cell responses when immunizing with multiepitope peptide vaccines | Q34657707 | ||
Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques | Q35001598 | ||
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways | Q35070674 | ||
Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. | Q35559497 | ||
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction | Q35561405 | ||
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients | Q35567048 | ||
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice | Q35848213 | ||
Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population. | Q35874111 | ||
Immunosuppression in patients who die of sepsis and multiple organ failure | Q35991015 | ||
Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study | Q36053935 | ||
The late phase of sepsis is characterized by an increased microbiological burden and death rate | Q36070469 | ||
The dual functions of receptor interacting protein 1 in fas-induced hepatocyte death during sepsis | Q36394948 | ||
Role of IL-15 in Sepsis-Induced Skeletal Muscle Atrophy and Proteolysis | Q36512051 | ||
B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. | Q36729527 | ||
Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets | Q36742299 | ||
Prevention of lymphocyte cell death in sepsis improves survival in mice | Q36748242 | ||
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis | Q36750008 | ||
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. | Q36941194 | ||
Regulatory T cell populations in sepsis and trauma. | Q36959555 | ||
Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis | Q36997987 | ||
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach | Q37233354 | ||
Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1. | Q37238322 | ||
The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients | Q37309561 | ||
PD-L1 blockade attenuated sepsis-induced liver injury in a mouse cecal ligation and puncture model. | Q37351521 | ||
Cytomegalovirus reactivation in critically ill immunocompetent patients | Q37414600 | ||
Endotoxin tolerance: new mechanisms, molecules and clinical significance | Q37603612 | ||
Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency. | Q37678563 | ||
Neutrophil paralysis in sepsis | Q37780438 | ||
Harnessing the biology of IL-7 for therapeutic application | Q37867487 | ||
Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival | Q37989867 | ||
The function of neutrophils in sepsis | Q37994057 | ||
Interleukin-15 in gene therapy of cancer. | Q38060229 | ||
B7 family checkpoint regulators in immune regulation and disease | Q38129635 | ||
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial | Q38316900 | ||
Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. | Q38483410 | ||
Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteria | Q39855993 | ||
Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes. | Q40684512 | ||
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome | Q41155671 | ||
Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. | Q41663817 | ||
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction | Q41897433 | ||
Dose-dependent effect of anti-CTLA-4 on survival in sepsis | Q41976084 | ||
The sepsis seesaw: tilting toward immunosuppression | Q42035078 | ||
Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis | Q42229245 | ||
Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway | Q43064735 | ||
Decreased T-cell repertoire diversity in sepsis: a preliminary study | Q43514997 | ||
Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated k | Q44234592 | ||
Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity | Q44569265 | ||
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte | Q45018156 | ||
Benchmarking the incidence and mortality of severe sepsis in the United States | Q45240119 | ||
Virus detection in patients with severe pneumonia: still more questions than answers? | Q45355493 | ||
TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy | Q46421735 | ||
Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice | Q48648759 | ||
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. | Q52909875 | ||
Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patients | Q56906281 | ||
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction | Q57773627 | ||
IL-7 Restores Lymphocyte Functions in Septic Patients | Q60547571 | ||
Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock | Q60547604 | ||
p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group | Q73343490 | ||
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans | Q73896312 | ||
Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patients | Q77754550 | ||
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice | Q77788085 | ||
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis | Q77855901 | ||
Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis | Q78109886 | ||
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways | Q81621957 | ||
Sepsis: calming the cytokine storm | Q84135047 | ||
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis | Q84255932 | ||
P433 | issue | 4 | |
P921 | main subject | sepsis | Q183134 |
P304 | page(s) | 224-233 | |
P577 | publication date | 2014-01-30 | |
P1433 | published in | Trends in Molecular Medicine | Q15265842 |
P1476 | title | The new normal: immunomodulatory agents against sepsis immune suppression | |
P478 | volume | 20 |
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Q38801190 | Association between mRNA expression of CD74 and IL10 and risk of ICU-acquired infections: a multicenter cohort study |
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Q41167339 | Effects of enteral nutrition with parenteral glutamine supplementation on the immunological function in septic rats |
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