Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells

scientific article published on 27 August 2016

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.11645
P932PMC publication ID5341874
P698PubMed publication ID27572309

P2093author name stringFeng Liu
Lei Gao
Feng Xu
Shuo Zhang
Ting Wang
Jing Feng
Tian Yang
Mingwei Chen
Hui Ren
Hua Guo
Dong Shang
Puyu Shi
Tianjun Chen
Yiqian Liang
Johnson J Liu
Asmitananda Thakur
P2860cites workActivity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivationQ38949674
PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathwaysQ38951260
Induction of autophagy counteracts the anticancer effect of cisplatin in human esophageal cancer cells with acquired drug resistanceQ38955141
Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cellsQ39053954
Autophagy proteins regulate ERK phosphorylationQ39062345
Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathwayQ39078533
The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo.Q39317004
MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB ReceptorsQ39355055
Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells.Q39750232
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cellsQ42478581
Assessment of the In Vivo Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal CancerQ53410679
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationQ24616946
Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase InhibitorQ27676347
Autophagy in the Pathogenesis of DiseaseQ27860558
Cancer statistics, 2015Q27860576
Autophagy: process and functionQ29547296
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HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinomaQ34017957
Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viabilityQ34096767
Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasoneQ34420112
Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.Q35374899
Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagyQ35556966
Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cellsQ35670413
MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell CarcinomaQ36021572
A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cellsQ36140634
Antitumor Activity of NVP-BKM120—A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma CellsQ37203000
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibitionQ37445131
The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosisQ37583704
Biomarkers with Predictive and Prognostic Function in Non–Small Cell Lung Cancer: Ready for Prime Time?Q37777283
Autophagy as a target for anticancer therapyQ37876679
Prognostic and predictive biomarkers in lung cancer. A reviewQ38178187
Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid TumorsQ38406496
Predictive and Prognostic Biomarkers for Patients Treated with Anti-EGFR Agents in Lung Cancer: A Systemic Review and Meta-Analysis.Q38536755
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
autophagyQ288322
P304page(s)67277-67287
P577publication date2016-08-27
P1433published inOncotargetQ1573155
P1476titleBlockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells
P478volume7

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cites work (P2860)
Q55322517Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells.
Q48651245ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma
Q90679554Effect of combined treatment with a pan-PI3K inhibitor or an isoform-specific PI3K inhibitor and everolimus on cell proliferation in GH-secreting pituitary tumour in an experimental setting
Q47122504Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells
Q52363953Pan-class I  PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.
Q61455097Targeted therapies for advanced non-small cell lung cancer
Q47110143Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
Q100415901The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells

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