Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway

scientific article published on 15 December 2016

Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.13947
P932PMC publication ID5351600
P698PubMed publication ID27992365

P2093author name stringYing Sun
Yong Han
Zhao Chen
Qiang Lu
Xiao-Fei Li
Xiao-Long Yan
Zhi-Pei Zhang
Xue-Jiao Wang
Wu-Ping Wang
Jin-Bo Zhao
Yun-Feng Ni
Ju-Zheng Wang
P2860cites workReduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomasQ22010990
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Complex networks orchestrate epithelial-mesenchymal transitionsQ29547478
Lung cancerQ29615473
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitroQ29617927
Gradually elevated expression of Gankyrin during human hepatocarcinogenesis and its clinicopathological significanceQ33851157
Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cellsQ34028736
FoxQ1 overexpression influences poor prognosis in non-small cell lung cancer, associates with the phenomenon of EMT.Q34326636
Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinomaQ34583510
Crosstalk of Oncogenic Signaling Pathways during Epithelial-Mesenchymal TransitionQ34677454
L1CAM protein expression is associated with poor prognosis in non-small cell lung cancerQ35416836
Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung CancerQ35958155
Identification of a novel role of RING finger protein 11 promoting the metastasis of murine melanoma cellsQ36225861
YAP is a critical oncogene in human cholangiocarcinomaQ36232005
Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathwayQ36346927
High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosisQ36546475
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cellQ36764852
Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.Q36863127
LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/STAT3/Akt pathwayQ37369888
Epithelial mesenchymal transition in drug resistance and metastasis of lung cancerQ38054713
Regulatory networks defining EMT during cancer initiation and progressionQ38076317
Lung cancer in China: challenges and interventionsQ38094966
Status of anti-lung cancer drug patents applications in China from 2003 to 2012.Q38156487
Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancerQ38786493
Gankyrin facilitates follicle-stimulating hormone-driven ovarian cancer cell proliferation through the PI3K/AKT/HIF-1α/cyclin D1 pathwayQ38835733
JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cellsQ39020685
Gankyrin is essential for hypoxia enhanced metastatic potential in breast cancer cellsQ39043522
Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6.Q39099246
Clinicopathologic features and prognostic implications of Gankyrin protein expression in non-small cell lung cancerQ39134905
Gankyrin activates IL-8 to promote hepatic metastasis of colorectal cancerQ39168162
Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expressionQ39218576
Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activityQ39298025
The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumoursQ39512984
Gankyrin promotes the proliferation of human pancreatic cancerQ39702569
Upregulated fascin1 in non-small cell lung cancer promotes the migration and invasiveness, but not proliferationQ39788953
Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significanceQ40068246
Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling.Q40468389
International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising.Q45110608
Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.Q53090136
Ep-CAM overexpression in breast cancer as a predictor of survivalQ73328477
Epithelial to mesenchymal transition: the doorway to metastasis in human lung cancersQ84772564
[Epithelial-mesenchymal transition in non-small cell lung cancer]Q85226803
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectnon-small-cell lung carcinomaQ3658562
P304page(s)5909-5923
P577publication date2016-12-15
P1433published inOncotargetQ1573155
P1476titleGankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway
P478volume8

Reverse relations

cites work (P2860)
Q93187485DHX9 inhibits epithelial-mesenchymal transition in human lung adenocarcinoma cells by regulating STAT3
Q89572810Fingolimod inhibits proliferation and epithelial-mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signalling
Q90989203KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling
Q90429861The Oncoprotein Gankyrin/PSMD10 as a Target of Cancer Therapy

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