Mitotic force generators and chromosome segregation

scientific article published on 10 March 2010

Mitotic force generators and chromosome segregation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00018-010-0326-6
P932PMC publication ID2883081
P698PubMed publication ID20221784
P5875ResearchGate publication ID41896466

P50authorJonathan M ScholeyQ114513705
Gul Civelekoglu-ScholeyQ115279160
P2860cites workCENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphaseQ24302159
Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochoreQ24305358
Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosisQ24315967
The conserved KMN network constitutes the core microtubule-binding site of the kinetochoreQ24320105
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motilityQ24601419
All kinesin superfamily protein, KIF, genes in mouse and humanQ24632779
A bipolar kinesinQ24633398
A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryosQ24634178
Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibresQ24649746
Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpointQ24649800
The kinesin-like protein KLP61F is essential for mitosis in DrosophilaQ24651223
Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivationQ24652311
The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignmentQ24653914
Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitroQ24669545
Mitotic centromere-associated kinesin is important for anaphase chromosome segregationQ24670465
The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindlesQ24670581
[Polarization optical studies of the mitotic spindle. I. The demonstration of spindle fibers in living cells]Q73252573
Measurement of the force-velocity relation for growing microtubulesQ73823827
Fluorescent speckle microscopy of spindle microtubule assembly and motility in living cellsQ77801943
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochoreQ24682934
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complexQ27324199
Chromosomes can congress to the metaphase plate before biorientationQ27332199
Structure of the Kinesin13-Microtubule Ring ComplexQ27652865
ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome MovementQ27653383
Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeastQ27930346
Novel roles for saccharomyces cerevisiae mitotic spindle motorsQ27934047
Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubulesQ27938562
Two mitotic kinesins cooperate to drive sister chromatid separation during anaphaseQ28235011
Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachmentsQ28236606
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule endsQ28238186
Dynamic instability of microtubule growthQ29547522
Mitotic spindle organization by a plus-end-directed microtubule motorQ29616139
High-resolution model of the microtubuleQ29618379
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1Q29618389
Kinesin-related proteins required for structural integrity of the mitotic spindleQ29636252
Protein architecture of the human kinetochore microtubule attachment siteQ30436130
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do workQ30450974
Microtubule flux and sliding in mitotic spindles of Drosophila embryosQ30476615
Model of chromosome motility in Drosophila embryos: adaptation of a general mechanism for rapid mitosisQ30477305
Functional coordination of three mitotic motors in Drosophila embryosQ30477413
Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradientQ30480485
Kinesin-13s form rings around microtubulesQ30480526
Dynamic partitioning of mitotic kinesin-5 cross-linkers between microtubule-bound and freely diffusing states.Q30482990
Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosisQ30486464
Ncd motor binding and transport in the spindleQ30487273
Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cellsQ30487858
The distribution of polar ejection forces determines the amplitude of chromosome directional instabilityQ30488889
The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusionQ30490445
Kinesin-5 acts as a brake in anaphase spindle elongationQ30491649
The Drosophila kinesin-13, KLP59D, impacts Pacman- and Flux-based chromosome movementQ30491665
Chromosome congression in the absence of kinetochore fibresQ30495251
The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assemblyQ30499485
Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryoQ30654911
Model for anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongationQ30835545
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanicsQ36322983
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell lineQ36323349
Roles of kinesin and kinesin-like proteins in sea urchin embryonic cell division: evaluation using antibody microinjectionQ36383220
Inhibition of anaphase spindle elongation in vitro by a peptide antibody that recognizes kinesin motor domainQ36421849
Cell motility by labile association of molecules. The nature of mitotic spindle fibers and their role in chromosome movementQ36427621
Chromosome motion during attachment to the vertebrate spindle: initial saltatory-like behavior of chromosomes and quantitative analysis of force production by nascent kinetochore fibersQ36529708
Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts.Q36531791
Kinetochore microtubules in PTK cellsQ36533211
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tetherQ36625807
Modeling of chromosome motility during mitosis.Q36625814
Poleward transport of Eg5 by dynein-dynactin in Xenopus laevis egg extract spindlesQ36843155
Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignmentQ36890066
Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores.Q37267720
Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A.Q37323122
Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion.Q37353009
Dynein antagonizes eg5 by crosslinking and sliding antiparallel microtubulesQ37440564
Theoretical problems related to the attachment of microtubules to kinetochoresQ37545521
Identification and partial characterization of six members of the kinesin superfamily in DrosophilaQ37597638
Force and length in the mitotic spindleQ37631261
New look inside the spindle: microtubule-dependent microtubule generation within the spindleQ37659553
An essential bipolar mitotic motorQ38970539
The forces that move chromosomes in mitosisQ39653525
A simple, mechanistic model for directional instability during mitotic chromosome movementsQ40209278
Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteinsQ40358374
Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase.Q40456129
Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.Q41193119
Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescenceQ41583375
Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysisQ44039726
The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule endsQ44348888
Identification of microtubule binding sites in the Ncd tail domainQ44856733
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.Q45952803
Kinetic analysis of mitotic spindle elongation in vitro.Q46007717
Kin I kinesins are microtubule-destabilizing enzymesQ46042447
SnapShot: motor proteins in spindle assemblyQ46218283
Interphase chromosomes undergo constrained diffusional motion in living cellsQ46252294
A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assaysQ46303403
Isolation of a sea urchin egg kinesin-related protein using peptide antibodiesQ46744079
Drosophila Klp67A is required for proper chromosome congression and segregation during meiosis I.Q47072781
The mitotic kinesin-14 Ncd drives directional microtubule-microtubule slidingQ47833249
Arrangement of subunits in flagellar microtubules.Q47866991
Dynein: A Protein with Adenosine Triphosphatase Activity from CiliaQ47891476
Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioningQ48074617
Retrograde transport by the microtubule-associated protein MAP 1C.Q48183505
Opposite end assembly and disassembly of microtubules at steady state in vitroQ48231342
Structural studies on porcine brain tubulin in extended sheetsQ48256687
Microtubule Formation in vitro in Solutions Containing Low Calcium ConcentrationsQ48726718
Minus-end-directed motor Ncd exhibits processive movement that is enhanced by microtubule bundling in vitro.Q50649458
Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.Q52123192
Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization.Q52210566
The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor.Q52239281
Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans.Q52254905
The Drosophila claret segregation protein is a minus-end directed motor molecule.Q52449568
Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos.Q52599609
Architecture of the microtubule component of mitotic spindles from Dictyostelium discoideum.Q52872528
Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP.Q54039178
Identification of kinesin in sea urchin eggs and evidence for its localization in the mitotic spindleQ59082527
Kinesin-8 Motors Act Cooperatively to Mediate Length-Dependent Microtubule DepolymerizationQ60193585
Klp67A destabilises pre-anaphase microtubules but subsequently is required to stabilise the central spindleQ60227680
Microtubule dynamics in the chromosomal spindle fiber: analysis by fluorescence and high-resolution polarization microscopyQ67950302
Direct visualization of microtubule flux during metaphase and anaphase in crane-fly spermatocytesQ30839538
Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutationsQ30856494
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinksQ33214719
Force production by disassembling microtubulesQ33227340
The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientationsQ33390650
Chromosome motors on the move. From motion to spindle checkpoint activityQ33757574
Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryosQ33880076
Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeastQ33911156
Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryosQ33930488
Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeastQ33948791
Microtubule motors in mitosisQ34036578
Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulansQ34169213
Clamped-filament elongation model for actin-based motorsQ34177114
A force balance model of early spindle pole separation in Drosophila embryos.Q34180288
The dynamic kinetochore-microtubule interfaceQ34362671
Theoretical studies on oscillations in microtubule polymerizationQ34370983
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dyneinQ34507133
Slide-and-cluster models for spindle assemblyQ34663861
Polymer motors: pushing out the front and pulling up the backQ35295016
Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomesQ36118138
Mechanism and function of poleward flux in Xenopus extract meiotic spindlesQ36129388
The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatusQ36189164
The mechanism of action of colchicine. Binding of colchincine-3H to cellular proteinQ36189186
Cross-sectional structure of the central mitotic spindle of Diatoma vulgare. Evidence for specific interactions between antiparallel microtubulesQ36203857
Structural polarity of kinetochore microtubules in PtK1 cellsQ36204428
Measurements of the force produced by the mitotic spindle in anaphaseQ36207654
Tubulin dynamics in cultured mammalian cellsQ36212188
Interzone microtubule behavior in late anaphase and telophase spindlesQ36217377
MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like propertiesQ36217545
Three-dimensional reconstruction and analysis of mitotic spindles from the yeast, Schizosaccharomyces pombeQ36232215
Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitroQ36235181
Kinetochore microtubule dynamics and the metaphase-anaphase transitionQ36236166
Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrixQ36294036
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindlesQ36322575
P433issue13
P304page(s)2231-2250
P577publication date2010-03-10
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleMitotic force generators and chromosome segregation
P478volume67

Reverse relations

cites work (P2860)
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