Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis.

scientific article published on 20 March 2017

Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2017.00300
P932PMC publication ID5357868
P698PubMed publication ID28373873

P50authorWinfried B. GraningerQ38639365
P2093author name stringChristina Duftner
Christian Dejaco
Anja Ficjan
Rusmir Husic
Wolfgang Schwinger
Christine Schwarz
Martin H Stradner
Andrea Raicht
Johannes Fessler
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritisQ28118730
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CCR6 regulates the migration of inflammatory and regulatory T cellsQ28511778
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfQ29619194
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systemsQ32044990
The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritisQ33226724
A peripheral circulating compartment of natural naive CD4 TregsQ33865874
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitisQ33966409
Cellular senescence and the senescent secretory phenotype: therapeutic opportunitiesQ34035882
Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteriaQ34055060
Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritisQ34182804
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Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral bloodQ34566056
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T cell homeostasis in patients with rheumatoid arthritisQ35200330
Telomere dysfunction, autoimmunity and aging.Q35806766
TNF downmodulates the function of human CD4+CD25hi T-regulatory cellsQ35849817
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotypeQ36059631
Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin HomingQ36177006
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.Q36266520
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Premature senescence of T-cell subsets in axial spondyloarthritisQ36761951
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CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis.Q36978507
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivationQ36984057
Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.Q37089409
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CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene.Q38339106
CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged miceQ40278187
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaksQ40593721
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Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapyQ42971266
A simplified disease activity index for rheumatoid arthritis for use in clinical practiceQ44321551
Prognostic markers of radiographic progression in early rheumatoid arthritisQ44733614
Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosusQ46156032
Effects of glucocorticoid treatment on CD25⁻FOXP3⁺ population and cytokine-producing cells in rheumatoid arthritis.Q47983201
Persistence of naive CD45RA+ regulatory T cells in adult life.Q51986549
Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood.Q52012409
Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.Q52047628
CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluidQ56903335
Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapyQ61628454
Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serumQ70399995
Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patientsQ70844259
Validation of rheumatoid arthritis improvement criteria that include simplified joint countsQ77430935
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritisQ80650174
Regulatory/suppressor T cells in health and diseaseQ80806146
Tissue trafficking patterns of effector memory CD4+ T cells in rheumatoid arthritisQ81576259
Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4+CD25+ forkhead box protein 3+ regulatory T cells is associated with the polarization of Treg/Th17 balance in a mouse modelQ82583397
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
P304page(s)300
P577publication date2017-03-20
P1433published inFrontiers in ImmunologyQ27723748
P1476titleNovel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis
P478volume8

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cites work (P2860)
Q90446908Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression
Q55057811Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines.
Q58718098Expression levels of IL-15 and IL-17 in synovial fluid of rheumatoid arthritis animal model
Q59805387Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population
Q59330026Increased activated regulatory T cell subsets and aging Treg-like cells in multiple myeloma and monoclonal gammopathy of undetermined significance: a case control study
Q42777634Leveraging blood and tissue CD4+ T cell heterogeneity at the single cell level to identify mechanisms of disease in rheumatoid arthritis.
Q50129651Regulatory T cells with a defect in inhibition on co-stimulation deteriorated primary biliary cholangitis
Q89861814Technical Considerations in Ex Vivo Human Regulatory T Cell Migration and Suppression Assays
Q57456657Telomere dysfunction-related serological markers and oxidative stress markers in rheumatoid arthritis patients: correlation with diseases activity

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