Gene models of schizophrenia: DISC1 mouse models

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Gene models of schizophrenia: DISC1 mouse models is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0079-6123(09)17909-8
P698PubMed publication ID20302820

P2093author name stringHanna Jaaro-Peled
P2860cites workDISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutationQ24305439
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophreniaQ24306904
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Neuregulin 1 and susceptibility to schizophreniaQ24616921
Disruption of two novel genes by a translocation co-segregating with schizophreniaQ28144559
Antidepressant-like effects in various mice strains in the forced swimming test.Q44325070
Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia.Q44824095
Neuregulin-1 immunoglobulin-like domain mutant mice: clozapine sensitivity and impaired latent inhibitionQ45261553
Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.Q46302011
Behavioral characteristics of a nervous system-specific erbB4 knock-out mouseQ46523281
Behavioral phenotypes of Disc1 missense mutations in miceQ48178658
Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1.Q48400355
Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout miceQ48463807
DISC1 immunoreactivity at the light and ultrastructural level in the human neocortexQ48516263
Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development.Q51040069
Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.Q51738410
Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv miceQ64018589
Interfrontal commissural abnormality in schizophrenia: tractography-assisted callosal parcellationQ81330445
Genetics. Two genes link two distinct psychosesQ81491935
Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowthQ28188775
The DISC locus in psychiatric illnessQ28251868
The genetics and biology of DISC1--an emerging role in psychosis and cognitionQ28252172
Association within a family of a balanced autosomal translocation with major mental illnessQ28257476
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signalingQ28282412
Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiologyQ28294217
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brainQ28507787
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1Q28576213
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex developmentQ28582746
Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit componentsQ28585466
Cortical inhibitory neurons and schizophreniaQ29547683
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophreniaQ29618963
Control of memory formation through regulated expression of a CaMKII transgeneQ29619261
Construct Validity of the Animal Latent Inhibition Model of Selective Attention Deficits in SchizophreniaQ30048705
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.Q30489568
The family of sensorimotor gating disorders: comorbidities or diagnostic overlaps?Q30490231
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humansQ30496743
Cross-species studies of sensorimotor gating of the startle reflexQ33692772
Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout miceQ34217453
Neuregulin and ErbB receptor signaling pathways in the nervous systemQ34278032
Brain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studiesQ34479485
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in miceQ34574484
Preclinical models: status of basic research in depressionQ34934319
Neuregulins: functions, forms, and signaling strategiesQ35089314
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in miceQ36156959
A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditionsQ36517223
Modeling madness in mice: one piece at a timeQ36610374
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognitionQ36657533
Role of DISC1 in neural development and schizophreniaQ36720430
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brainQ36893742
Modeling cognitive endophenotypes of schizophrenia in miceQ37055287
Neuregulin 1 in neural development, synaptic plasticity and schizophreniaQ37163033
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.Q37588242
Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1.Q40054801
Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1).Q44264433
P921main subjectschizophreniaQ41112
P304page(s)75-86
P577publication date2009-11-20
P1433published inProgress in Brain ResearchQ15800382
P1476titleGene models of schizophrenia: DISC1 mouse models
P478volume179

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Q37131089Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?

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